Journal ArticleDOI
Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection.
Annuurun Nisa,Franciele Cristina Kipper,Dipak Panigrahy,Sangeeta Tiwari,Andreas Kupz,Selvakumar Subbian +5 more
- Vol. 323, Iss: 5, pp C1444-C1474
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TLDR
Different modalities of Mtb-mediated host cell deaths, the molecular mechanisms underpinning the host cell death during Mtb infection, and its potential implications for host immunity are summarized.Abstract:
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), a leading infectious disease of humans worldwide. One of the main histopathological hallmarks of TB is the formation of granulomas comprised of elaborately organized aggregates of immune cells containing the pathogen. Dissemination of Mtb from infected cells in the granulomas due to host and mycobacterial factors induces multiple cell death modalities in infected cells. Based on molecular mechanism, morphological characteristics, and signal dependency, there are two main categories of cell death: programmed and non-programmed. Programmed cell death (PCD), such as apoptosis and autophagy, is associated with a protective response to Mtb by keeping the bacteria encased within dead macrophages that can be readily phagocytosed by arriving uninfected or neighboring cells. In contrast, non-PCD necrotic cell death favors the pathogen, resulting in the bacterial release into the extracellular environment. Multiple types of cell death in the PCD category, including pyroptosis, necroptosis, ferroptosis, ETosis, parthanatos, and PANoptosis, may be involved in Mtb infection. Since PCD pathways are essential for host immunity to Mtb, therapeutic compounds targeting cell death signaling pathways have been experimentally tested for TB treatment. This review summarizes different modalities of Mtb-mediated host cell deaths, the molecular mechanisms underpinning the host cell death during Mtb infection, and its potential implications for host immunity. Additionally, targeting host cell death pathways as potential therapeutic and preventive approaches against Mtb infection is also discussed.read more
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Journal ArticleDOI
Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example
TL;DR: In this article , the interrelationship between programmed cell death and immunogenic cell death (ICD) is investigated using nanomedicines as examples, and the relationship between PCD and ICD and its application prospects in the development of new ICD nanomaterials are summarized.
Journal ArticleDOI
The molecular mechanisms of cuproptosis and its relevance to cardiovascular disease.
TL;DR: A detailed review of the molecular mechanisms involved in cuproptosis and its significance in cardiovascular disease can be found in this paper , where copper-dependent anomalous oligomerization of lipoylation proteins is discussed.
Journal ArticleDOI
Cisatracurium besylate rescues Mycobacterium Tuberculosis-infected macrophages from necroptosis and enhances the bactericidal effect of isoniazid.
Qian Wen,Jing Zhang,Liru Chen,Honglin Liu,Zhenyu Han,Yaoxin Chen,Ke Wang,Jieyu Liu,Nagaraja Prasad Sai,Xinying Zhou,Chaoying Zhou,Shengfeng Hu,Li Ma +12 more
TL;DR: Cisatracurium besylate was found to be highly protective for the viability of macrophages during Mycobacterium tuberculosis infection via inhibiting necroptosis as discussed by the authors .
Journal ArticleDOI
PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis
TL;DR: In this article , the authors focus on the relationship between pyroptosis, apoptosis, and necroptosis and provide a basis for targeted intervention of PANoptosis-related molecules to treat human diseases.
Journal ArticleDOI
Mycobacterium tuberculosis and SARS-CoV-2 co-infections: The knowns and unknowns
TL;DR: In this article , the authors highlighted dysregulated immune responses induced by SARS-CoV-2 and Mtb, their potential interplay, and implications for co-infection in the lungs.
References
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Journal ArticleDOI
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Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
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Journal ArticleDOI
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
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