Journal ArticleDOI
Diminished metabolic responses to centrally-administered apelin-13 in diet-induced obese rats fed a high-fat diet.
TLDR
A diminished central nervous system response to apelin that is coincident with obesity is demonstrated.Abstract:
The central administration of apelin, a recently identified adipokine, has been shown to affect food and water intake. The present study investigated whether body weight could affect an animal’s response to apelin. The effects of centrally-administered apelin-13 on food and water intake, activity and metabolic rate were investigated in adult male diet-induced obese (DIO) rats fed either a high fat (32%) or control diet. Rats were administered i.c.v. apelin-13, 15–30 min prior to lights out, and food and water intake, activity and metabolic rate were assessed. Intracerebroventricular administration of apelin-13 decreased food and water intake and respiratory exchange ratio in DIO rats on the control diet, but had no effect in DIO rats on the high-fat diet. In an effort to identify potential central mechanisms explaining the observed physiological responses, the mRNA level of the apelin receptor, APJ, was examined in the hypothalamus. A high-fat diet induced an up-regulation of the expression of the receptor. Apelin induced a down-regulation of the receptor, but only in the DIO animals on the high-fat diet. In conclusion, we have demonstrated a diminished central nervous system response to apelin that is coincident with obesity.read more
Citations
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Journal ArticleDOI
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
TL;DR: The physiological and pathological roles that support this system as a novel therapeutic target for pharmacological intervention in treating conditions related to altered water balance, stress-induced disorders such as anxiety and depression, and cardiovascular and metabolic disorders are highlighted.
Journal ArticleDOI
Apelin, diabetes, and obesity.
Isabelle Castan-Laurell,Cédric Dray,Camille Attané,Thibaut Duparc,Claude Knauf,Philippe Valet +5 more
TL;DR: Apelin appears as a beneficial adipokine with anti-obesity and anti-diabetic properties and thus as a promising therapeutic target in metabolic disorders.
Journal ArticleDOI
The apelin receptor: Physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR
TL;DR: This minireview outlines key (patho)physiological actions of the AR, addresses what is known about signal transduction downstream of AR activation, and concludes by discussing unique properties of the endogenous peptidic ligands of theAR.
Journal ArticleDOI
Apelin, a promising target for type 2 diabetes treatment?
Isabelle Castan-Laurell,Cédric Dray,Cédric Dray,Claude Knauf,Claude Knauf,Oxana Kunduzova,Oxana Kunduzova,Philippe Valet,Philippe Valet +8 more
TL;DR: This review describes the various metabolic functions that are affected by apelin and presents an integrated overview of recent findings that collectively propose apelin as a promising target for the treatment of T2DM.
Journal Article
Brain and cardiovascular diseases: common neurogenic background of cardiovascular, metabolic and inflammatory diseases
TL;DR: The studies surveyed in this review suggest that multiple brain mechanisms interact together sharing the same neural circuits responsible for adjustment of function of the cardiovascular system and metabolism to current needs.
References
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Journal ArticleDOI
From the authors
Y. Lacasse,F. Maltais +1 more
TL;DR: Findings, i.e. that as-needed AO provided for a period of 3 months had no effect on quality of life and walked distance, are against the stream of current guidelines.
Journal ArticleDOI
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Kazuhiko Tatemoto,Masaki Hosoya,Yugo Habata,Ryo Fujii,Tadao Kakegawa,Min-Xu Zou,Yuji Kawamata,Shoji Fukusumi,Shuji Hinuma,Chieko Kitada,Tsutomu Kurokawa,Haruo Onda,Masahiko Fujino +12 more
TL;DR: Synthetic peptides derived from the C-terminal amino acid sequence of bovine preproapelin were capable of specifically promoting the acidification rate in the cells expressing the APJ receptor in a range from 10(-7) to 10(-10) M, indicating that apelin is an endogenous ligand for theAPJ receptor.
Journal ArticleDOI
Apelin, a newly identified adipokine up-regulated by insulin and obesity
Jeremie Boucher,Bernard Masri,Danièle Daviaud,Stephane Gesta,Charlotte Guigné,Anne Mazzucotelli,Isabelle Castan-Laurell,Ivan Tack,Bernard Knibiehler,Christian Carpéné,Yves Audigier,Jean-Sébastien Saulnier-Blache,Philippe Valet +12 more
TL;DR: Apelin is identified as a novel adipocyte endocrine secretion and its potential link with obesity-associated variations of insulin sensitivity status is focused on and evidence that insulin exerts a direct control on apelin gene expression in adipocytes is provided.
Journal ArticleDOI
Molecular and anatomical determinants of central leptin resistance
Heike Münzberg,Martin G. Myers +1 more
TL;DR: The mechanisms by which leptin activates intracellular signals, the roles of these signals in leptin action in vivo, and mechanisms that may attenuate leptin signaling, limiting its action in obese individuals are reviewed.
Journal ArticleDOI
Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats.
TL;DR: The DIO and DR traits in the outbred Sprague-Dawley population appear to be due to a polygenic pattern of inheritance.
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