Journal ArticleDOI
Diruthenium(II, III) complexes of ibuprofen, aspirin, naproxen and indomethacin non-steroidal anti-inflammatory drugs: Synthesis, characterization and their effects on tumor-cell proliferation
Reads0
Chats0
TLDR
Ru2(dNSAID)4Cl] and novel [Ru2d NSAID4(H2O)2] PF6 complexes, where dNSAID =deprotonated carboxylate from the non-steroidal anti-inflammatory drugs (NSAIDs), respectively: ibuprofen, Hibp (1) and aspirin, Hasp (2); naproxen, Hnpx (3) and indomethacin, Hind (4), have been prepared and characterized by optical spectroscopic methods as mentioned in this paper.About:
This article is published in Polyhedron.The article was published on 2008-02-26. It has received 88 citations till now. The article focuses on the topics: Naproxen.read more
Citations
More filters
Journal ArticleDOI
Toward Multi-Targeted Platinum and Ruthenium Drugs-A New Paradigm in Cancer Drug Treatment Regimens?
Reece G. Kenny,Celine J. Marmion +1 more
TL;DR: This review has endeavored to showcase how a "multitargeted" approach to drug design has led to new families of metallodrugs which may not only reduce systemic toxicities associated with modern day chemotherapeutics but also address resistance issues that are plaguing many Chemotherapeutic regimens.
Journal ArticleDOI
Interaction of copper(II) with the non-steroidal anti-inflammatory drugs naproxen and diclofenac: Synthesis, structure, DNA- and albumin-binding
Filitsa Dimiza,Franc Perdih,Vassilis Tangoulis,Iztok Turel,Dimitris P. Kessissoglou,George Psomas +5 more
TL;DR: The cyclic voltammograms of the complexes recorded in the presence of CT DNA have shown that the complexes can bind to CT DNA by the intercalative binding mode which has also been verified by DNA solution viscosity measurements.
Journal ArticleDOI
Biological evaluation of cobalt(II) complexes with non-steroidal anti-inflammatory drug naproxen.
Filitsa Dimiza,Athanasios N. Papadopoulos,Vassilis Tangoulis,Vassilis Psycharis,Catherine P. Raptopoulou,Dimitris P. Kessissoglou,George Psomas +6 more
TL;DR: Cobalt(II) complexes with the non-steroidal anti-inflammatory drug naproxen in the presence of nitrogen-donor heterocyclic ligands (pyridine, 2,2'-bipyridine or 1,10-phenanthroline) have been synthesized and characterized with physicochemical and spectroscopic techniques.
Journal ArticleDOI
Cobalt(II) complexes with non-steroidal anti-inflammatory drug tolfenamic acid: Structure and biological evaluation
Sofia Tsiliou,Lida-Aikaterini Kefala,Franc Perdih,Iztok Turel,Dimitris P. Kessissoglou,George Psomas +5 more
TL;DR: Tolfenamic acid and its cobalt(II) complexes exhibit good binding propensity to human or bovine serum albumin protein having relatively high binding constant values.
Journal ArticleDOI
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Metal Complexes and Their Effect at the Cellular Level
TL;DR: The study shows that the molecular weights of metal complexes containing the same NSAID are linearly related to their IC50 values against MCF-7 cells, and compounds with low molecular weight strongly bind to DNA.
References
More filters
Book
Infrared and Raman Spectra of Inorganic and Coordination Compounds
TL;DR: In this article, the normal modes of vibration are illustrated and corresponding vibrational frequencies are listed for each type, including diatomic, triatomic, fouratomic, five-atomic, six-atomic and seven-atomic types.
Journal ArticleDOI
The use of conductivity measurements in organic solvents for the characterisation of coordination compounds
Journal ArticleDOI
Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues
TL;DR: Generic approaches to improve the balance between benefits and risks associated with the use of NSAIDs in chemoprevention are considered and strategies to overcome the various logistic and scientific barriers that impede clinical trials ofNSAIDs for cancer prevention are identified.
Book
Multiple bonds between metal atoms
TL;DR: In this paper, the authors present a survey of complexes of the Group 5 Elements, including Chromium, Molybdenum, Tungsten and Technetium.
Journal ArticleDOI
From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
Christian G. Hartinger,Stefanie Zorbas-Seifried,Michael A. Jakupec,Bernd Kynast,Haralabos Zorbas,Bernhard K. Keppler +5 more
TL;DR: The preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated and promising activity against certain types of tumors is observed.