Disparity for the minor histocompatibility antigen HA-1 is associated with an increased risk of acute graft-versus-host disease (GvHD) but it does not affect chronic GvHD incidence, disease-free survival or overall survival after allogeneic human leucocyte antigen-identical sibling donor transplantation
David Gallardo,Juan I. Aróstegui,Antonio Balas,Antoni Torres,Dolores Caballero,Enric Carreras,Salut Brunet,Antonio Abrante Jiménez,Rodolfo Mataix,D Serrano,Carlos Vallejo,Guillermo Sanz,Carlos Solano,Marta Rodriguez-Luaces,J. Marin,Julio Baro,César Sanz,José Alberto San Román,Marcos González,Jaume Martorell,Jorge Sierra,Carmen Martín,Rafael de la Cámara,Albert Grañena +23 more
TLDR
The association between HA‐1 mismatch and risk of mild acute GvHD was confirmed, but HA‐ 1 mismatch was not associated with an increased incidence of chronic Gv HD and did not affect relapse or overall survival.Abstract:
Disparity for the minor histocompatibility antigen HA-1 between patient and donor has been associated with an increased risk of acute graft-versus-host disease (GvHD) after allogeneic human leucocyte antigen (HLA)-identical sibling donor stem cell transplantation (SCT). However, no data concerning the impact of such disparity on chronic GvHD, relapse or overall survival are available. A retrospective multicentre study was performed on 215 HLA-A2-positive patients who received an HLA-identical sibling SCT, in order to determine the differences in acute and chronic GvHD incidence on the basis of the presence or absence of the HA-1 antigen mismatch. Disease-free survival and overall survival were also analysed. We detected 34 patient–donor pairs mismatched for HA-1 antigen (15·8%). Grades II–IV acute GvHD occurred in 51·6% of the HA-1-mismatched pairs compared with 37·1% of the non-mismatched. The multivariate logistic regression model showed statistical significance (P: 0·035, OR: 2·96, 95% CI: 1·07–8·14). No differences were observed between the two groups for grades III–IV acute GvHD, chronic GvHD, disease-free survival or overall survival. These results confirmed the association between HA-1 mismatch and risk of mild acute GvHD, but HA-1 mismatch was not associated with an increased incidence of chronic GvHD and did not affect relapse or overall survival.read more
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Journal ArticleDOI
Relevance of KIR gene polymorphisms in bone marrow transplantation outcome.
Katia Gagne,Géraldine Brizard,Brigitte Gueglio,Noel Milpied,Patricia Herry,F. Bonneville,Mary Luce Chéneau,Nicolas Schleinitz,Anne Cesbron,Gilles Folléa,Jean Luc Harrousseau,Jean Bignon +11 more
TL;DR: A great diversity for KIR genotypes in donors and recipients of BMT is revealed and that the risk of GVHD was maximum in unrelated BMT when the recipient Kir genotype was "included" in the donor KIRgenotype.
Journal ArticleDOI
Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report.
Kirk R. Schultz,David B. Miklos,Daniel H. Fowler,Ken Cooke,Judith A. Shizuru,Emmanuel Zorn,Ernst Holler,James L.M. Ferrara,Howard M. Shulman,Stephanie J. Lee,Paul J. Martin,Alexandra H. Filipovich,Mary E.D. Flowers,Daniel J. Weisdorf,Daniel R. Couriel,Peter A. Lachenbruch,Barbara B. Mittleman,Georgia B. Vogelsang,Steven Z. Pavletic +18 more
TL;DR: No validated biomarker studies have been established for chronic GVHD, although several candidate biomarkers have been identified from limited hypothesis-driven studies and high-throughput discovery-based methods.
Journal ArticleDOI
New approaches for preventing and treating chronic graft-versus-host disease
TL;DR: Potential new approaches to the prevention and treatment of chronic GVHD are covered in this review.
Journal ArticleDOI
Beyond HLA: the significance of genomic variation for allogeneic hematopoietic stem cell transplantation
Ann Mullally,Jerome Ritz +1 more
TL;DR: It is apparent that the extent of genetic dissimilarity between any 2 individuals is considerable and much greater than that which was previously recognized.
Journal ArticleDOI
Immunotherapy of cancer through targeting of minor histocompatibility antigens.
Lothar Hambach,Els Goulmy +1 more
TL;DR: Targeting tumour-specific minor histocompatibility antigens by adoptive immunotherapy will battle against tumour tolerance and evoke allo-immune responses, thereby enhancing graft-versus-tumour effects against leukaemia and solid tumours.
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Mismatches of Minor Histocompatibility Antigens between HLA-Identical Donors and Recipients and the Development of Graft-Versus-Host Disease after Bone Marrow Transplantation
Els Goulmy,R. Schipper,Jos Pool,E. Blokland,J.H.F. Falkenburg,Jaak M. Vossen,Alois Gratwohl,Georgia B. Vogelsang,J.C. van Houwelingen,J.J. van Rood +9 more
TL;DR: A mismatch of minor histocompatibility antigen HA-1 can cause GVHD in adult recipients of allogeneic bone marrow from HLA-identical donors, and ProspectiveHA-1 typing may improve donor selection and identify recipients who are at high risk for GV HD.