Journal ArticleDOI
Dissection of memory formation: from behavioral pharmacology to molecular genetics
Jim DeZazzo,Tim Tully +1 more
TLDR
These studies support the application of reverse-genetic strategies, including the use of temporally specific agonists and antagonists, to advance the functional dissection of memory formation.About:
This article is published in Trends in Neurosciences.The article was published on 1995-05-01. It has received 281 citations till now. The article focuses on the topics: Memory consolidation.read more
Citations
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The Neurobiology of Consolidations, Or, How Stable is the Engram?
TL;DR: A heated debate has been revitalized on whether memories become labile and must undergo some form of renewed consolidation every time they are activated, and on fundamental issues concerning the nature of the memory trace, its maturation, persistence, retrievability, and modifiability.
Journal ArticleDOI
Mushroom body memoir: From maps to models
TL;DR: Genetic intervention in the fly Drosophila melanogaster has provided strong evidence that the mushroom bodies of the insect brain act as the seat of a memory trace for odours, and the development of a circuit model that addresses this function might allow the mushrooms to throw light on the basic operating principles of the brain.
Journal ArticleDOI
CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression
TL;DR: Two important Ca2+/calmodulin (CaM)-regulated mechanisms in hippocampal neurons are found: a CaM kinase cascade involving nuclear CaMKIV and a calcineurin-dependent regulation of nuclear protein phosphatase 1 activity.
Journal ArticleDOI
Psychobiology of plasticity: effects of training and experience on brain and behavior
TL;DR: Enriched experience and training appear to evoke the same cascade of neurochemical events in causing plastic changes in brain, andufficiently rich experience may be necessary for full growth of species-specific brain characteristics and behavioral potential.
Journal ArticleDOI
Guidelines on nicotine dose selection for in vivo research
Shannon G. Matta,David J.K. Balfour,Neal L. Benowitz,R. Thomas Boyd,Jerry J. Buccafusco,Anthony R. Caggiula,Caroline R. Craig,Allan C. Collins,M. Imad Damaj,Eric C. Donny,Phillip S. Gardiner,Sharon R. Grady,Ulrike Heberlein,Sherry Leonard,Edward D. Levin,Ronald J. Lukas,Athina Markou,Michael J. Marks,Sarah E. McCallum,Neeraja Parameswaran,Kenneth A. Perkins,Marina R. Picciotto,Maryka Quik,Jed E. Rose,Adrian Rothenfluh,William R Schafer,Ian P. Stolerman,Rachel F. Tyndale,Jeanne M. Wehner,Jeffrey M. Zirger +29 more
TL;DR: A new, experimentally based compilation of species-specific dose selection for studies on the in vivo effects of nicotine, addressing issues related to genetic background, age, acute vs chronic exposure, route of administration, and behavioral responses is provided.
References
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Journal ArticleDOI
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
Andrea H. Brand,Norbert Perrimon +1 more
TL;DR: The GAL4 system, a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety of tissue- and cell-specific patterns, has been designed and used to expand the domain of embryonic expression of the homeobox protein even-skipped.
Journal ArticleDOI
Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning
R. G. Phillips,Joseph E. LeDoux +1 more
TL;DR: An associative roles for the amygdala and a sensory relay role for the hippocampus are suggested in fear conditioning, which is involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli.
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Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.