Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.
Selina Khan,Martijn S. Bijker,Jimmy J. Weterings,Hans J. Tanke,Gosse J. Adema,Thorbald van Hall,Jan W. Drijfhout,Cornelis J. M. Melief,Hermen S. Overkleeft,Gijsbert A. van der Marel,Dmitri V. Filippov,Sjoerd H. van der Burg,Ferry Ossendorp +12 more
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TLDR
The data show that targeting to two distinct TLRs requires distinct uptake mechanism but follows similar trafficking and intracellular processing pathways leading to optimal antigen presentation and T-cell priming.About:
This article is published in Journal of Biological Chemistry.The article was published on 2007-07-20 and is currently open access. It has received 174 citations till now. The article focuses on the topics: Antigen processing & Antigen presentation.read more
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Dendritic-cell-based therapeutic cancer vaccines.
TL;DR: The immunological basis for therapeutic cancer vaccines and how the current understanding of dendritic cell and T cell biology might enable the development of next-generation curative therapies for individuals with cancer are discussed.
Journal ArticleDOI
Therapeutic cancer vaccines
TL;DR: The clinical benefit of therapeutic cancer vaccines has been established and the specificity of therapeutic vaccination combined with such immunomodulation offers an attractive avenue for the development of future cancer therapies.
Journal ArticleDOI
Vaccines for established cancer: overcoming the challenges posed by immune evasion.
TL;DR: How therapeutic benefit can be maximized in patients with established cancers by using vaccines to increase the effects of standard chemotherapies, to establish and/or maintain tumour-specific T cells that are re-energized by checkpoint blockade and other therapies, and to sustain the antitumour response of adoptively transferred T cells is summarized.
Journal ArticleDOI
Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
TL;DR: This Review deals with recent progress in the immunotherapy of established (pre)malignant disease of viral or non-viral origin by synthetic vaccines capable of inducing robust T-cell responses.
Journal ArticleDOI
Cancer Immunotherapy by Dendritic Cells
TL;DR: The considerations for generating promising therapeutic antitumor vaccines that use DCs are discussed, and chemotherapies, causing DC activation, enhanced crosspresentation, lymphodepletion, and reduction of immunosuppressive leukocytes, act synergistically with vaccines or adoptive T cell transfer.
References
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Immunobiology of Dendritic Cells
Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
Journal ArticleDOI
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.
TL;DR: The capacity of DCs to capture and process antigen could be modulated by exogenous stimuli was investigated and it was found that DCs respond to tumor necrosis factor alpha, CD40 ligand, IL-1, and lipopolysaccharide with a coordinate series of changes that include downregulation of macropinocytosis and Fc receptors, disappearance of the class II compartment, and upregulation of adhesion and costimulatory molecules.
Journal ArticleDOI
Dendritic cells: specialized and regulated antigen processing machines.
Ira Mellman,Ralph M. Steinman +1 more
TL;DR: Dendritic cells are adept at endocytosis and express relatively low levels of surface MHC class I and II products and costimu-latory molecules, but can take up antigen tive responses critical for resistance to infections and but do not present it efficiently to T cells.
Journal ArticleDOI
Caveolin, a protein component of caveolae membrane coats.
Karen G. Rothberg,John E. Heuser,William C. Donzell,Yun-shu Ying,John R. Glenney,Richard G.W. Anderson +5 more
TL;DR: Structural analysis of the striated coat of caveolae reveals a third type of coated membrane specialization that is involved in molecular transport and is named caveolin, suggesting that this molecule is a component of the coat.
Journal ArticleDOI
Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.
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