Journal ArticleDOI
DNA Binding and Anti-Cancer Activity of Redox-Active Heteroleptic Piano-Stool Ru(II), Rh(III), and Ir(III) Complexes Containing 4-(2-Methoxypyridyl)phenyldipyrromethene
Rakesh Kumar Gupta,Rampal Pandey,Gunjan Sharma,Ritika Prasad,Biplob Koch,Saripella Srikrishna,Pei-Zhou Li,Qiang Xu,Daya Shankar Pandey +8 more
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TLDR
The results suggest that in vitro antitumor activity of 1-4 lies in the order 2 > 1 > 4 > 3.Abstract:
The synthesis of four novel heteroleptic dipyrrinato complexes [(η6-arene)RuCl(2-pcdpm)] (η6-arene = C6H6, 1; C10H14, 2) and [(η5-C5Me5)MCl(2-pcdpm)] (M = Rh, 3; Ir, 4) containing a new chelating ligand 4-(2-methoxypyridyl)-phenyldipyrromethene (2-pcdpm) have been described. The complexes 1–4 have been fully characterized by various physicochemical techniques, namely, elemental analyses, spectral (ESI-MS, IR, 1H, 13C NMR, UV/vis) and electrochemical studies (cyclic voltammetry (CV) and differential pulse voltammetry (DPV)). Structures of 3 and 4 have been determined crystallographically. In vitro antiproliferative and cytotoxic activity of these complexes has been evaluated by trypan blue exclusion assay, cell morphology, apoptosis, acridine orange/ethidium bromide (AO/EtBr) fluorescence staining, and DNA fragmentation assay in Dalton lymphoma (DL) cell lines. Interaction of 1–4 with calf thymus DNA (CT DNA) has also been supported by absorption titration and electrochemical studies. Our results suggest t...read more
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Antitumour metal compounds: more than theme and variations
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
Journal ArticleDOI
DNA/protein binding, molecular docking, and in vitro anticancer activity of some thioether-dipyrrinato complexes.
Rakesh Kumar Gupta,Gunjan Sharma,Rampal Pandey,Amit Kumar,Biplob Koch,Pei-Zhou Li,Qiang Xu,Daya Shankar Pandey +7 more
TL;DR: A remarkable decrease in the in vitro DL cell proliferation and induction of the apoptosis by 1-4 is revealed, which lies in the order 2 > 1 > 4 > 3.
Journal ArticleDOI
Ruthenium(II) arene complexes containing benzhydrazone ligands: synthesis, structure and antiproliferative activity
TL;DR: The results of AO–EB, Hoechst 33258 and flow cytometry analyses reveal that these complexes induce cell death only through apoptosis, highlighting the strong possibility to develop highly active ruthenium complexes as anticancer agents.
Journal ArticleDOI
Luminescent dipyrrin based metal complexes
TL;DR: The different types of modification of dipyrrin as well as the resulting metal complexes incorporating these derivatives, their photophysical properties and their applications in sensing and materials science are reviewed.
Journal ArticleDOI
Synthesis and molecular structure of arene ruthenium(II) benzhydrazone complexes: impact of substitution at the chelating ligand and arene moiety on antiproliferative activity
TL;DR: The results of Western blot analyses suggest that complexes 3 and 6 accumulate preferentially in the mitochondria of MDA-MB-231 cells and induce apoptosis via mitochondrial pathways by up-regulating p53 and Bax, and down- Regulating Bcl-2.
References
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Journal ArticleDOI
Voltammetric studies of the interaction of metal chelates with DNA. 2. Tris-chelated complexes of cobalt(III) and iron(II) with 1,10-phenanthroline and 2,2'-bipyridine
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