Journal ArticleDOI
Does smoking stimulate rheumatoid factor production in non‐rheumatic individuals?
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TLDR
It is indicated that smoking may influence the immune system, leading to increased production of IgM and IgA RF, which is associated with increased incidence of rheumatoid arthritis and joint damage.Abstract:
Smoking has been associated with increased incidence of rheumatoid arthritis (RA), joint damage and positive rheumatoid factor (RF). Here we report an analysis of the association between smoking and IgM, IgG and IgA RF in a cohort of non-rheumatic individuals participating in a prospective longitudinal study of the incidence and significance of elevated RF. From the initial cohort of nearly 14,000 randomly selected individuals aged 52-80 years, 109 RF-positive and 187 RF-negative non-rheumatic participants were recruited. All participants were tested for RF at least twice at an interval ranging from 4 to 13 years. Of the RF-negative participants 21.9% were active smokers compared to 34.1% of IgM RF-positive (p=0.035), 20.8% of IgG RF-positive (N.S.) and 34.4% of IgA RF-positive participants (p=0.047). Smoking was most prevalent (44.8%) amongst participants with elevation of both IgM and IgA RF (p=0.008), and smokers were also significantly more likely to have a persistent elevation of RF than non-smokers (p=0.024). These findings indicate that smoking may influence the immune system, leading to increased production of IgM and IgA RF.read more
Citations
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Journal ArticleDOI
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.
Solbritt Rantapää-Dahlqvist,Ben A. W. de Jong,Ewa Berglin,Göran Hallmans,Göran Wadell,Hans Stenlund,Ulf Sundin,Walther J. van Venrooij +7 more
TL;DR: Anti-CCP antibody and RFs of all isotypes predated the onset of RA by several years, indicating that citrullination and the production of anti- CCP and RF autoantibodies are early processes in RA.
Journal ArticleDOI
Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases
Patrik Stolt,Camilla Bengtsson,B Nordmark,Sverker Lindblad,Ingrid E. Lundberg,Lars Klareskog,Lars Alfredsson +6 more
TL;DR: Smokers of both sexes have an increased risk of developing seropositive, but not seronegative, RA, which occurs after a long duration, but merely a moderate intensity, of smoking and may remain for several years after smoking cessation.
Journal ArticleDOI
Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies.
Daisuke Sugiyama,Kunihiro Nishimura,Kunihiro Nishimura,Kenichiro Tamaki,Goh Tsuji,Takashi Nakazawa,Akio Morinobu,Shunichi Kumagai +7 more
TL;DR: Whether smoking is a risk factor for developing rheumatoid arthritis (RA) is assessed, especially RF+ RA men and heavy smokers.
Journal ArticleDOI
Smoking, rheumatoid factor isotypes and severity of rheumatoid arthritis
TL;DR: Smoking has an adverse effect on disease progression in patients with RA and an association was also observed between smoking and those RF types that predispose to RA and have the highest diagnostic specificity for this disease.
Journal ArticleDOI
Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis
TL;DR: Coffee consumption may be a risk factor for RA, possibly through mechanisms contributing to the production of RF, and this hypothesis remains to be tested in further studies.
References
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Journal ArticleDOI
1958 Revision of diagnostic criteria for rheumatoid arthritis
Journal ArticleDOI
1958 Revision of Diagnostic Criteria for Rheumatoid Arthritis
Journal ArticleDOI
Cigarette smoking and rheumatoid arthritis severity
Kenneth G. Saag,James R. Cerhan,Sheela Kolluri,Kenjirou Ohashi,Gary W. Hunninghake,David A. Schwartz +5 more
TL;DR: Pack years of cigarette smoking was significantly associated with rheumatoid factor seropositivity, radiographic erosions, and nodules, and Cigarette smoking may adversely influence the severity of RA in a potentially dose dependent fashion.
Journal ArticleDOI
Rheumatoid factor, complement, and conglutinin aberrations in patients with subacute bacterial endocarditis*
Journal Article
Smoking, obesity, alcohol consumption, and the risk of rheumatoid arthritis.
TL;DR: A population-based case-control study of rheumatoid arthritis in King County, WA, and Group Health Cooperative of Puget Sound found that post-menopausal women who averaged more than 14 alcoholic drinks per week had a reduced risk of r hematological arthritis.
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