Journal ArticleDOI
Dopaminergic system and monoamine oxidase-B activity in Alzheimer's disease.
Kari J. Reinikainen,Leo Paljärvi,Toivo Halonen,Outi Malminen,Veli-Matti Kosma,Markku Laakso,Paavo Riekkinen +6 more
TLDR
Coexistent PD pathology can explain the loss of DA in the striatum and the presence of clinical PD symptoms in some patients with AD/SDAT, but the clinical relevance of these dopaminergic alterations is unclear.About:
This article is published in Neurobiology of Aging.The article was published on 1988-01-01. It has received 114 citations till now. The article focuses on the topics: Substantia nigra & Dopaminergic.read more
Citations
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Chlorinative stress: an under appreciated mediator of neurodegeneration?
TL;DR: In this paper, a review of the current understanding concerning the association of HOCl and neuronal cell death is presented, where the authors conclude that HOCl is a major oxidant produced by activated phagocytes in the presence of myeloperoxidase.
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Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function.
TL;DR: Plants and their constituents with pharmacological activities that may be relevant for the treatment of cognitive disorders, including enhancement of cholinergic function in the central nervous system (CNS), anti-inflammatory and antioxidant activities, are discussed.
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Are reactive oxygen species involved in Alzheimer's disease?
Gianni Benzi,Antonio Moretti +1 more
TL;DR: This review examines the possibility of oxidative stress, meaning an imbalance between the formation and spread of reactive oxygen species (ROS) and the antioxidant defenses, and the pro-aggregating effect of ROS on beta/A4 protein and the C-terminal fragment of amyloid precursor (A4CT).
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Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography.
Josep Saura,J.M. Luque,Cesura Andrea,M. Da Prada,V. Chan-Palay,Gerda Huber,J. Löffler,J. G. Richards +7 more
TL;DR: It is concluded that enzyme radioautography with [3H]lazabemide is a reliable high resolution assay for plaque-associated astroglioses in Alzheimer's disease and might, indirectly, be a potential source of cytotoxic free radicals.
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Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain.
TL;DR: The present evidence suggests that, whereas MAO-A is found in noradrenergic and adrenergic neurons,MAO-B occurs in astrocytes, serotoninergic neuron, as well as ventricular cells, including most circumventricular organs.
References
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Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey.
TL;DR: Evidence is provided that dopamine plays an important role in a specific cortical function in rhesus monkeys and that this role can be pharmacologically reversed with dopamine agonists.
Journal Article
Biochemical pathophysiology of Parkinson's disease.
Oleh Hornykiewicz,S J Kish +1 more
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Some morphometric aspects of the brain in senile dementia of the Alzheimer type.
TL;DR: Image analysis apparatus was used to count and measure glial and neuronal perikarya in ten size classes in the midfrontal region and superior temporal gyrus of 18 patients with senile dementia of the Alzheimer type for comparison with 12 age‐matched normal specimens.
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Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease.
TL;DR: In patients who had discontinued L-DOPA at least 4 days before death (group I), the levels of dopamine and its metabolites were reduced in these cortical areas, although to a lesser extent than in the caudate nucleus.
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Neocortical cell counts in normal human adult aging.
TL;DR: Aging affects the frontal and temporal lobes more than the parietal; the salient change is shrinkage of large neurons with consequently increasing numbers of small neurons in the midfrontal and superior temporal areas.