Journal ArticleDOI
Double strand breaks may be a missing link between entropy and aging.
TLDR
This work proposes a new model where the increase of entropy leads to the formation of double strand breaks, resulting in an aging phenotype, which not only offers a new perspective on aging research and facilitates experimental validation, but could also serve as a useful explanatory tool.About:
This article is published in Mechanisms of Ageing and Development.The article was published on 2016-07-01. It has received 11 citations till now. The article focuses on the topics: Entropy production & Entropy (arrow of time).read more
Citations
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Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg,Heide Knauer,Alexandra Schauer,Sabrina Büttner,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Julia Ring,Sabrina Schroeder,Christoph Magnes,Lucia Antonacci,Heike Fussi,Luiza Deszcz,Luiza Deszcz,Regina Hartl,Regina Hartl,Elisabeth Schraml,Alfredo Criollo,Evgenia Megalou,Daniela Weiskopf,Peter Laun,Gino Heeren,Michael Breitenbach,Beatrix Grubeck-Loebenstein,Eva Herker,Birthe Fahrenkrog,Kai-Uwe Fröhlich,Frank Sinner,Nektarios Tavernarakis,Nadège Minois,Nadège Minois,Nadège Minois,Guido Kroemer,Frank Madeo +32 more
TL;DR: Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
Journal ArticleDOI
Keeping up with the Red Queen: the pace of aging as an adaptation.
TL;DR: The current state of the debate is reviewed and it is suggested that although aging is in essence inevitable and results from damage accumulation rather than from a specific program, the actual rate of aging in nature may still be adaptive to some extent.
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Thermodynamics, ecology and evolutionary biology: A bridge over troubled water or common ground?
TL;DR: It is suggested that thermodynamics may provide a bridge between ecology and evolutionary biology, and that this will enable us to move forward with otherwise intractable problems.
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Why women may live longer than men do? A telomere-length regulated and diet-based entropic assessment.
TL;DR: A higher rate of metabolism causes higher entropy generation and hints correlations that can be helpful in future ageing research.
Journal ArticleDOI
Can aging research generate a theory of health
TL;DR: In this paper, the authors investigate whether we can find, implicit within the sciences of aging, a way to know what health is and how to measure it, i.e. a theory of health.
References
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Journal ArticleDOI
The Hallmarks of Aging
TL;DR: Nine tentative hallmarks that represent common denominators of aging in different organisms are enumerated, with special emphasis on mammalian aging, to identify pharmaceutical targets to improve human health during aging, with minimal side effects.
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The Role of Chromatin during Transcription
TL;DR: This Review highlights advances in the understanding of chromatin regulation and discusses how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.
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Molecular chaperones in protein folding and proteostasis
TL;DR: It is suggested that an age-related decline in proteostasis capacity allows the manifestation of various protein-aggregation diseases, including Alzheimer's disease and Parkinson's disease, which may spring from a detailed understanding of the pathways underlying proteome maintenance.
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A DNA damage checkpoint response in telomere-initiated senescence
Fabrizio d'Adda di Fagagna,Philip Michael Reaper,Lorena Clay-Farrace,Heike Fiegler,Philippa Carr,Thomas von Zglinicki,Gabriele Saretzki,Nigel P. Carter,Stephen P. Jackson +8 more
TL;DR: It is proposed that telomere-initiated senescence reflects a DNA damage checkpoint response that is activated with a direct contribution from dysfunctional telomeres.
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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
TL;DR: In this paper, the lifespan of C. elegans strains containing duplications of chromosomal regions was surveyed and it was shown that a duplication containing sir-2.1-the SIR2 gene most homologous to yeast-confers a lifespan that is extended by up to 50%.