Journal ArticleDOI
Dual activity of triterpenoids: apoptotic versus antidifferentiation effects
TLDR
It is suggested that although triterpenoids UA and OA can induce apoptosis, their antioxidant activities can interfere with the therapeutic effect of antitumor antibiotic Dox which mechanism of action is attributed to the production of reactive oxygen species.Abstract:
Triterpenoids are natural, biologically active compounds extracted from many plants. They possess antiinflammatory, anticancer, and antioxidant properties. In the report presented, antiproliferative effects and leukemia cell growth and apoptosis modulating activities of ursolic acid (UA) and oleanolic acid (OA) were investigated. Both triterpenoids are inhibitors of leukemia cell growth and inductors of apoptosis. However, when applied in combination with anthracycline antitumor antibiotic doxorubicin (Dox), UA and OA diversely modulate therapeutic efficacy of Dox, due to different antioxidant activities. Compare to OA showing synergism/additive effect with Dox, UA (stronger antioxidant) acts antagonistically and reduces leukemia cell growth inhibiting and differentiation effects induced by Dox. In conclusion, these findings suggest that although triterpenoids UA and OA can induce apoptosis, their antioxidant activities can interfere with the therapeutic effect of antitumor antibiotic Dox which mechanism of action is attributed to the production of reactive oxygen species.read more
Citations
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Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms.
Parayil Kumaran Ajikumar,Keith E. J. Tyo,Simon Carlsen,Oliver Mucha,Too Heng Phon,Gregory Stephanopoulos +5 more
TL;DR: This review focuses on the biodiversity of terpenoids, the biosynthetic pathways involved, and engineering efforts to maximize the production through these pathways.
Journal ArticleDOI
Terpenes: substances useful in human healthcare.
TL;DR: The major conclusion is that larger-scale use of terpenoids in modern medicine should be taken into consideration.
Journal ArticleDOI
Traditional herbal medicine in Far-west Nepal: a pharmacological appraisal
TL;DR: Traditional herbal medicine has flourished in rural areas where modern medicine is parsimoniously accessed because of the high cost and long travel time to health center, and the latest pharmacological findings, common Ayurvedic and earlier uses were consistent.
Journal ArticleDOI
Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.
TL;DR: The antitumor and anti-HIV activities of naturally occurring triterpenoids, including the lupane, ursane, oleanane, lanostane, dammarane, and miscellaneous scaffolds are reviewed.
Journal ArticleDOI
Antioxidant, Antiproliferative, and Pro-apoptotic Capacities of Pentacyclic Triterpenes Found in the Skin of Olives on MCF-7 Human Breast Cancer Cells and Their Effects on DNA Damage
Yosra Allouche,Fernando Warleta,Maria Aparecida Santos e Campos,Cristina Sánchez-Quesada,Marino Uceda,Gabriel Beltrán,José J. Gaforio +6 more
TL;DR: The results suggest that tested triterpenes may have the potential to provide significant natural defense against human breast cancer.
References
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Journal Article
Evaluation of a Tetrazolium-based Semiautomated Colorimetric Assay: Assessment of Radiosensitivity
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Analysis of combined drug effects: a new look at a very old problem
Ting-Chao Chou,Paul Talalay +1 more
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