Journal ArticleDOI
Dysfunctional reward circuitry in obsessive-compulsive disorder.
Martijn Figee,Matthijs Vink,Femke de Geus,Nienke Vulink,Dick J. Veltman,Herman G.M. Westenberg,Damiaan Denys +6 more
Reads0
Chats0
TLDR
This first functional imaging study to investigate explicitly reward circuitry in OCD shows attenuated reward anticipation activity in the nucleus accumbens compared with healthy control subjects, and supports the conceptualization of OCD as a disorder of reward processing and behavioral addiction.About:
This article is published in Biological Psychiatry.The article was published on 2011-05-01. It has received 270 citations till now. The article focuses on the topics: Addiction & Behavioral addiction.read more
Citations
More filters
Journal ArticleDOI
Longitudinal association between motor and obsessive compulsive symptoms in patients with psychosis and their unaffected siblings.
TL;DR: Motor symptoms might precede co-occurring OCS in patients with psychotic disorders, but no inference can be made about causality, and further prospective research is needed to investigate this assumption.
Journal ArticleDOI
Large nest building and high marble-burying: Two compulsive-like phenotypes expressed by deer mice (Peromyscus maniculatus bairdii) and their unique response to serotoninergic and dopamine modulating intervention.
TL;DR: The naturally occurring compulsive-like behaviors expressed by deer mice may be useful in providing a platform to test unique treatment targets for different symptom dimensions of OCD and related disorders.
Journal ArticleDOI
Reduced striatal dopamine D2/3 receptor availability in Body Dysmorphic Disorder
TL;DR: This study provides the first evidence of a disturbed dopaminergic system in BDD patients, and gives pathophysiological support for the recent reclassification of BDD to the OCRD in DSM-5.
Journal ArticleDOI
A mathematical model of reward and executive circuitry in obsessive compulsive disorder.
Anca Rǎdulescu,Rachel Marra +1 more
TL;DR: In this article, the authors investigated a collection of connectivity hypotheses of OCD by means of a computational model of the brain circuitry that governs reward and motion execution, and suggested that it is a combination of parameters (connectivity strengths between regions), rather than the value of any one parameter taken independently, that provide the best basis for predicting behavior, and for understanding the heterogeneity of the illness.
Journal ArticleDOI
The course of the neural correlates of reversal learning in obsessive–compulsive disorder and major depression: A naturalistic follow-up fMRI study
Sander C.J. Verfaillie,Stella J. de Wit,Chris Vriend,Peter L. Remijnse,Dick J. Veltman,Odile A. van den Heuvel +5 more
TL;DR: The results show that in both disorders frontal-striatal dysfunction is at least partly state-dependent, and symptom reduction over time was associated with partial normalization of task-related activation patterns in brain regions.
References
More filters
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Journal Article
The Mini-International Neuropsychiatric Interview (M.I.N.I.) : The development and validation of a Structured Diagnostic Psychiatric Interview for DSM-IV and ICD-10
David V. Sheehan,Yves Lecrubier,Kathy Harnett Sheehan,P. Amorim,J. Janavs,Emmanuelle Weiller,T. Hergueta,Ross A. Baker,Dunbar Geoffrey Charles +8 more
TL;DR: The Mini-International Neuropsychiatric Interview is designed to meet the need for a short but accurate structured psychiatric interview for multicenter clinical trials and epidemiology studies and to be used as a first step in outcome tracking in nonresearch clinical settings.
Journal ArticleDOI
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Wayne K. Goodman,Lawrence H. Price,Steven A. Rasmussen,Carolyn M. Mazure,Roberta L. Fleischmann,Candy L. Hill,George R. Heninger,Dennis S. Charney +7 more
TL;DR: In a study involving four raters and 40 patients with obsessive-compulsive disorder at various stages of treatment, interrater reliability for the total Yale-Brown Scale score and each of the 10 individual items was excellent, with high degree of internal consistency among all item scores demonstrated with Cronbach's alpha coefficient.
Journal ArticleDOI
The mini international neuropsychiatric interview
TL;DR: The results are interpreted as a support for the hypothesis that language-related brain functions are deficient in subgroups of schizophrenia and might be associated with compensatory contralateral activation.
Journal ArticleDOI
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Wayne K. Goodman,Lawrence H. Price,Steven A. Rasmussen,Carolyn M. Mazure,Pedro L. Delgado,George R. Heninger,Dennis S. Charney +6 more
TL;DR: Results from a previously reported placebo-controlled trial of fluvoxamine in 42 patients with obsessive-compulsive disorder showed that the Yale- Brown Scale was sensitive to drug-induced changes and that reductions in Yale-Brown Scale scores specifically reflected improvement in obsessive- compulsive disorder symptoms.
Related Papers (5)
Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways
Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience.
Benjamin D. Greenberg,Lutgardis Gabriëls,Donald A. Malone,Ali R. Rezai,G M Friehs,Michael S. Okun,Nathan A. Shapira,Kelly D. Foote,Paul Cosyns,Cynthia S. Kubu,Paul Malloy,Stephen Salloway,J E Giftakis,M T Rise,Andre G. Machado,Kenneth B. Baker,Paul H. Stypulkowski,Wayne K. Goodman,Steven A. Rasmussen,Bart Nuttin +19 more