Journal ArticleDOI
Dysfunctional reward circuitry in obsessive-compulsive disorder.
Martijn Figee,Matthijs Vink,Femke de Geus,Nienke Vulink,Dick J. Veltman,Herman G.M. Westenberg,Damiaan Denys +6 more
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TLDR
This first functional imaging study to investigate explicitly reward circuitry in OCD shows attenuated reward anticipation activity in the nucleus accumbens compared with healthy control subjects, and supports the conceptualization of OCD as a disorder of reward processing and behavioral addiction.About:
This article is published in Biological Psychiatry.The article was published on 2011-05-01. It has received 270 citations till now. The article focuses on the topics: Addiction & Behavioral addiction.read more
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Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder
Mónica Giménez,Mónica Giménez,Andrés Guinea-Izquierdo,Andrés Guinea-Izquierdo,Andrés Guinea-Izquierdo,Victoria Villalta-Gil,Victoria Villalta-Gil,Ignacio Martínez-Zalacaín,Cinto Segalàs,Cinto Segalàs,Marta Subirà,Marta Subirà,Marta Subirà,Eva Real,Eva Real,Jesús Pujol,Ben J. Harrison,Josep Maria Haro,Josep Maria Haro,João Ricardo Sato,Marcelo Q. Hoexter,Narcís Cardoner,Pino Alonso,Pino Alonso,Pino Alonso,José M. Menchón,José M. Menchón,José M. Menchón,Carles Soriano-Mas,Carles Soriano-Mas,Carles Soriano-Mas +30 more
TL;DR: It is suggested that the evaluation of the local attributes of BOLD signal across different frequency bands may be a sensitive approach to further characterize brain functional alterations in psychiatric disorders.
Brain Structure and Functional Connectivity Associated With Pornography Consumption
Simone Kühn,Jürgen Gallinat +1 more
TL;DR: The findings support the assumption that pornography has an impact on the behavior and social cognition of its consumers and find a significant negative association between reported pornography hours per week and gray matter volume in the right caudate and functional connectivity of the left dorsolateral prefrontal cortex.
Journal ArticleDOI
Diminishing striatal activation across adolescent development during reward anticipation in offspring of schizophrenia patients
Matthijs Vink,Max de Leeuw,Ruby Pouwels,Hanna E. van den Munkhof,René S. Kahn,Manon H.J. Hillegers +5 more
TL;DR: The results of this cross-sectional study indicate that the diminishing striatal activation across adolescence may signify a familial vulnerability for schizophrenia.
Journal ArticleDOI
Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges
TL;DR: It is argued that findings over the past decade indicate that the deer mouse model has face, construct and predictive validity, and may serve as a valid and useful model of OCD.
Journal ArticleDOI
Obsessive-compulsive and related disorders in international classification of Diseases-11 and its relation to international classification of Diseases-10 and diagnostic and statistical manual of mental Disorders-5
TL;DR: The rationale behind the creation of the new “Obsessive-Compulsive and Related Disorders (OCRD)” section in the ICD-11 chapter on Mental and Behavioral Disorders is discussed and it is compared with the I CD-10 and the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).
References
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Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Journal Article
The Mini-International Neuropsychiatric Interview (M.I.N.I.) : The development and validation of a Structured Diagnostic Psychiatric Interview for DSM-IV and ICD-10
David V. Sheehan,Yves Lecrubier,Kathy Harnett Sheehan,P. Amorim,J. Janavs,Emmanuelle Weiller,T. Hergueta,Ross A. Baker,Dunbar Geoffrey Charles +8 more
TL;DR: The Mini-International Neuropsychiatric Interview is designed to meet the need for a short but accurate structured psychiatric interview for multicenter clinical trials and epidemiology studies and to be used as a first step in outcome tracking in nonresearch clinical settings.
Journal ArticleDOI
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Wayne K. Goodman,Lawrence H. Price,Steven A. Rasmussen,Carolyn M. Mazure,Roberta L. Fleischmann,Candy L. Hill,George R. Heninger,Dennis S. Charney +7 more
TL;DR: In a study involving four raters and 40 patients with obsessive-compulsive disorder at various stages of treatment, interrater reliability for the total Yale-Brown Scale score and each of the 10 individual items was excellent, with high degree of internal consistency among all item scores demonstrated with Cronbach's alpha coefficient.
Journal ArticleDOI
The mini international neuropsychiatric interview
TL;DR: The results are interpreted as a support for the hypothesis that language-related brain functions are deficient in subgroups of schizophrenia and might be associated with compensatory contralateral activation.
Journal ArticleDOI
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Wayne K. Goodman,Lawrence H. Price,Steven A. Rasmussen,Carolyn M. Mazure,Pedro L. Delgado,George R. Heninger,Dennis S. Charney +6 more
TL;DR: Results from a previously reported placebo-controlled trial of fluvoxamine in 42 patients with obsessive-compulsive disorder showed that the Yale- Brown Scale was sensitive to drug-induced changes and that reductions in Yale-Brown Scale scores specifically reflected improvement in obsessive- compulsive disorder symptoms.
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Benjamin D. Greenberg,Lutgardis Gabriëls,Donald A. Malone,Ali R. Rezai,G M Friehs,Michael S. Okun,Nathan A. Shapira,Kelly D. Foote,Paul Cosyns,Cynthia S. Kubu,Paul Malloy,Stephen Salloway,J E Giftakis,M T Rise,Andre G. Machado,Kenneth B. Baker,Paul H. Stypulkowski,Wayne K. Goodman,Steven A. Rasmussen,Bart Nuttin +19 more