Journal ArticleDOI
Dysfunctional reward circuitry in obsessive-compulsive disorder.
Martijn Figee,Matthijs Vink,Femke de Geus,Nienke Vulink,Dick J. Veltman,Herman G.M. Westenberg,Damiaan Denys +6 more
Reads0
Chats0
TLDR
This first functional imaging study to investigate explicitly reward circuitry in OCD shows attenuated reward anticipation activity in the nucleus accumbens compared with healthy control subjects, and supports the conceptualization of OCD as a disorder of reward processing and behavioral addiction.About:
This article is published in Biological Psychiatry.The article was published on 2011-05-01. It has received 270 citations till now. The article focuses on the topics: Addiction & Behavioral addiction.read more
Citations
More filters
Journal ArticleDOI
Transcranial Magnetic Stimulation of the Supplementary Motor Area in the Treatment of Obsessive-Compulsive Disorder: A Multi-Site Study
TL;DR: RTMS appeared to significantly improve the OCD symptoms of the treated patients beyond the treatment window, and more studies need to be conducted to determine the generalizability of these findings and to define the duration of rTMS’ clinical effect on the Y-BOCS.
Journal ArticleDOI
Granisetron adjunct to fluvoxamine for moderate to severe obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial.
Neda Askari,Mahdieh Moin,Mohammad Hossein Sanati,Masih Tajdini,Seyed-Mohammad-Reza Hosseini,Amirhossein Modabbernia,Babak Najand,Samrand Salimi,Mina Tabrizi,Mandana Ashrafi,Reza Hajiaghaee,Shahin Akhondzadeh +11 more
TL;DR: Runisetron is an efficacious adjunct for the short-term treatment of patients with moderate to severe OCD and is well tolerated, compared with other 5-HT3 receptor antagonists.
Journal ArticleDOI
Structural neuroimaging correlates of social deficits are similar in autism spectrum disorder and attention-deficit/hyperactivity disorder: analysis from the POND Network
Danielle A. Baribeau,Annie Dupuis,Tara Paton,Christopher Hammill,Stephen W. Scherer,Stephen W. Scherer,Russell Schachar,Paul D. Arnold,Peter Szatmari,Peter Szatmari,Rob Nicolson,Stelios Georgiades,Jennifer Crosbie,Jessica Brian,Jessica Brian,Alana Iaboni,Azadeh Kushki,Azadeh Kushki,Jason P. Lerch,Evdokia Anagnostou,Evdokia Anagnostou +20 more
TL;DR: Overall, patterns of associations were similar in ASD and ADHD, supporting a common underlying biology and the blurring of the diagnostic boundaries between these disorders.
Journal ArticleDOI
In medication-overuse headache, fMRI shows long-lasting dysfunction in midbrain areas.
Stefania Ferraro,Licia Grazzi,Riccardo Muffatti,Simone Nava,F. Ghielmetti,Nicola Bertolino,Maria Luisa Mandelli,Eleonora Visintin,Maria Grazia Bruzzone,Anna Nigri,Francesca Epifani,Gennaro Bussone,Luisa Chiapparini +12 more
TL;DR: The primary aim of this study was to evaluate if a group of medication‐overuse headache patients present dysfunctions in the mesocorticolimbic dopamine circuit and to investigate their persistence.
Journal ArticleDOI
Four Deep Brain Stimulation Targets for Obsessive-Compulsive Disorder: Are They Different?
TL;DR: A review of the similarities and differences across targets, and the accuracy of diffusion magnetic resonance imaging tractography to replicate those connections in nonhuman primates, shows that the four targets generally involve similar connections, all of which are part of the internal capsule.
References
More filters
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Journal Article
The Mini-International Neuropsychiatric Interview (M.I.N.I.) : The development and validation of a Structured Diagnostic Psychiatric Interview for DSM-IV and ICD-10
David V. Sheehan,Yves Lecrubier,Kathy Harnett Sheehan,P. Amorim,J. Janavs,Emmanuelle Weiller,T. Hergueta,Ross A. Baker,Dunbar Geoffrey Charles +8 more
TL;DR: The Mini-International Neuropsychiatric Interview is designed to meet the need for a short but accurate structured psychiatric interview for multicenter clinical trials and epidemiology studies and to be used as a first step in outcome tracking in nonresearch clinical settings.
Journal ArticleDOI
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Wayne K. Goodman,Lawrence H. Price,Steven A. Rasmussen,Carolyn M. Mazure,Roberta L. Fleischmann,Candy L. Hill,George R. Heninger,Dennis S. Charney +7 more
TL;DR: In a study involving four raters and 40 patients with obsessive-compulsive disorder at various stages of treatment, interrater reliability for the total Yale-Brown Scale score and each of the 10 individual items was excellent, with high degree of internal consistency among all item scores demonstrated with Cronbach's alpha coefficient.
Journal ArticleDOI
The mini international neuropsychiatric interview
TL;DR: The results are interpreted as a support for the hypothesis that language-related brain functions are deficient in subgroups of schizophrenia and might be associated with compensatory contralateral activation.
Journal ArticleDOI
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Wayne K. Goodman,Lawrence H. Price,Steven A. Rasmussen,Carolyn M. Mazure,Pedro L. Delgado,George R. Heninger,Dennis S. Charney +6 more
TL;DR: Results from a previously reported placebo-controlled trial of fluvoxamine in 42 patients with obsessive-compulsive disorder showed that the Yale- Brown Scale was sensitive to drug-induced changes and that reductions in Yale-Brown Scale scores specifically reflected improvement in obsessive- compulsive disorder symptoms.
Related Papers (5)
Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways
Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience.
Benjamin D. Greenberg,Lutgardis Gabriëls,Donald A. Malone,Ali R. Rezai,G M Friehs,Michael S. Okun,Nathan A. Shapira,Kelly D. Foote,Paul Cosyns,Cynthia S. Kubu,Paul Malloy,Stephen Salloway,J E Giftakis,M T Rise,Andre G. Machado,Kenneth B. Baker,Paul H. Stypulkowski,Wayne K. Goodman,Steven A. Rasmussen,Bart Nuttin +19 more