Effect of 2-Hydroxy-4-Methoxy Benzoic Acid from the Roots of Hemidesmus indicus on Streptozotocin-induced Diabetic Rats.
M Gayathri,K. Kannabiran +1 more
Reads0
Chats0
TLDR
It can be concluded that HMBA mediated normalization of membrane-bound ATPase in erythrocytes is due to improved glycemic control and antioxidant activity.Abstract:
The aim of the present study was to investigate the effect of 2-hydroxy-4-methoxy benzoic acid isolated from the roots of Hemidesmus indicus on plasma glucose, plasma, erythrocyte and erythrocyte membrane lipid peroxidation and membrane-bound Ca(2+) ATPase activity in streptozotocin-induced diabetic rats. In our study, diabetic rats had increased levels of blood glucose and lipid peroxidation in plasma, erythrocytes and erythrocyte membrane and decreased level of plasma insulin and decreased activity of low affinity Ca(2+) ATPase in erythrocytes. Restoration of plasma insulin and glucose in diabetic rats indicates the effect of HMBA on insulin, glucose and lipid peroxidation. HMBA also restored diabetes-induced alterations in the activity of membrane-bound Ca(2+) ATPase. Based on the results of this study it can be concluded that HMBA mediated normalization of membrane-bound ATPase in erythrocytes is due to improved glycemic control and antioxidant activity.read more
Citations
More filters
Journal ArticleDOI
Plants Used to Treat Diabetes in Sri Lankan Siddha Medicine - An Ethnopharmacological Review of Historical and Modern Sources
Saravanan Vivekanandarajah Sathasivampillai,Pholtan R. S. Rajamanoharan,Michael R. Munday,Michael Heinrich +3 more
TL;DR: This is the first study systematically assessing the importance of preparations and plants used in antidiabetic Sri Lankan Siddha Medicine preparations and identified a wide range of methodological problems.
Journal ArticleDOI
Protective effect of 2-hydroxy-4-methoxy benzoic acid on testosterone induced benign prostatic hyperplasia in Wister rats.
TL;DR: The present study suggests the protective role of HMBA on testosterone induced BPH by virtue of its antioxidant potential, and significantly restored antioxidant enzyme levels, lipid peroxide and total nitrite when compared to disease control animals.
Journal ArticleDOI
2-Hydroxy-4-methoxy benzoic acid attenuates the carbon tetra chloride-induced hepatotoxicity and its lipid abnormalities in rats via anti-inflammatory and antioxidant mechanism
TL;DR: HMBA is competent of shielding liver from CCl4-induced hepatotoxicity, and this is associated with the lipid lowering, inflammatory cytokine restoration and induction of defensive enzyme activities.
Journal ArticleDOI
Effect of 2-Hydroxy-4-methoxy Benzoic Acid Isolated from Hemidesmus indicus on Erythrocyte Membrane Bound Enzymes and Antioxidant Status in Streptozotocin-induced Diabetic Rats.
M Gayathri,K. Kannabiran +1 more
TL;DR: Administration of 2-hydroxy-4-methoxy benzoic acid supports the restoration of antioxidant defence, reduces the free radial production, lipid peroxidation and the glycosylation of haemoglobin in diabetic rats.
Journal ArticleDOI
In vitro and in vivo studies of the antidiabetic potential of Red Sea sponge-associated fungus “Aspergillus unguis” isolate SP51-EGY with correlations to its chemical composition
TL;DR: Primary metabolites of Red Sea sponge-associated fungus isolate SP51-EGY could be considered an effective strategy in the regulation of blood glucose level because of their ability to inhibit α-glucosidase activity.
References
More filters
Journal ArticleDOI
Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor
TL;DR: It was found that the system of phenol and 4-amino phenazone is well suited to the determination of glucose and the development of phosphatase is described.
Book
Trease and Evans' Pharmacognosy
TL;DR: The scope and practice of pharmacognosy, the study of medicinal plants and animal-derived drugs, and the search for naturally-derived anticancer agents and miscellaneous glycosides are explained.
Journal ArticleDOI
Purification and characterization of two forms of a low-affinity Ca2+-ATPase from erythrocyte membranes
Stellan Hjertén,Huazhen Pan +1 more
TL;DR: The results obtained can be explained by assuming that the two proteins corresponding to the two bands obtained in SDS electrophoresis have a similar structure and can associate to complexes A and B and cause misinterpretation of the data obtained.
Journal ArticleDOI
Viper venom-induced inflammation and inhibition of free radical formation by pure compound (2-hydroxy-4-methoxy benzoic acid) isolated and purified from anantamul (Hemidesmus indicus R.Br) root extract
M.I. Alam,Aparna Gomes +1 more
TL;DR: The present investigation explored the possible venom neutralizing effect of a pure compound isolated and purified from the methanolic root extract of Hemidesmus indicus R.Rr.