Journal ArticleDOI
Effect of cell anisotropy on differentiation of stem cells on micropatterned surfaces through the controlled single cell adhesion.
TLDR
The present study makes semi-quantitative investigations of the effects of cell shape on differentiation of stem cells based on a material technique, and reveals that the shape anisotropy is very important in directing the lineage commitments ofstem cells.About:
This article is published in Biomaterials.The article was published on 2011-11-01. It has received 255 citations till now. The article focuses on the topics: Mesenchymal stem cell & Stem cell.read more
Citations
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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Guoyou Huang,Fei Li,Xin Zhao,Yufei Ma,Yuhui Li,Min Lin,Guorui Jin,Tian Jian Lu,Guy M. Genin,Feng Xu +9 more
TL;DR: This review encapsulates where recent advances appear to leave the ever-shifting state of the art in the cell microenvironment, and it highlights areas in which substantial potential and uncertainty remain.
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Cell–Material Interactions Revealed Via Material Techniques of Surface Patterning
TL;DR: The pertinent work sheds new insight into the cell–material interactions, and is stimulating for biomaterial design in regenerative medicine, tissue engineering, and high‐throughput detection, diagnosis, and drug screening.
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Poly(lactide-co-glycolide) porous scaffolds for tissue engineering and regenerative medicine
Zhen Pan,Jiandong Ding +1 more
TL;DR: In the latest decade, some facile fabrication approaches at room temperature were put forward; more appropriate pore structures were designed and achieved; the mechanical properties were investigated both for dry and wet scaffolds and the effects of pore size and porosity on in vitro biodegradation were revealed.
Journal ArticleDOI
Physical cues of biomaterials guide stem cell differentiation fate.
TL;DR: This paper presents a meta-analyses of the siamese egg implantation procedure and its applications in maternal and child health and development and shows clear trends in success and failure rates.
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Effects of micropitted/nanotubular titania topographies on bone mesenchymal stem cell osteogenic differentiation.
TL;DR: T titania nanotubes 25 and 80 nm in size with the acid-etched Ti topography and hierarchical hybrid micropitted/nanotubular topographies are produced to mimic the structure of the natural bone extracellular matrix, showing the best ability to simultaneously promote MSC proliferation and osteogenic differentiation.
References
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Journal ArticleDOI
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Geometric control of cell life and death.
TL;DR: Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension.
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Cell shape, cytoskeletal tension, and rhoa regulate stem cell lineage commitment
TL;DR: It is demonstrated that cell shape regulates commitment of human mesenchymal stem cells to adipocyte or osteoblast fate and mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate.
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Growth Factors, Matrices, and Forces Combine and Control Stem Cells
TL;DR: Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit.
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RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
TL;DR: The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed.