Journal ArticleDOI
Effect of Obesity on the Pharmacokinetics of Drugs in Humans
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TLDR
Clinicians should design treatment regimens that account for any significant differences in the CL and Vd in the obese, using a size descriptor that corrects for differences in absolute CL between obese and non-obese individuals.Abstract:
The prevalence of obesity has dramatically increased in recent years and now includes a significant proportion of the world’s children, adolescents and adults. Obesity is linked to a number of co-morbidities, the most prominent being type 2 diabetes mellitus. While many agents are available to treat these conditions, the current knowledge regarding their disposition in the obese remains limited.read more
Citations
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Journal ArticleDOI
Physiologically-based pharmacokinetics in drug development and regulatory science.
TL;DR: Specific advances and contemporary challenges with respect to predicting the processes of drug clearance, distribution, and absorption are reviewed, together with the ability to anticipate the quantitative extent of PK-based drug-drug interactions and the impact of age, genetics, disease, and formulation.
Journal ArticleDOI
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp.
Khalid O. Alfarouk,Christian Stock,Sophie Taylor,Megan M. Walsh,Abdel Khalig Muddathir,Daniel Verduzco,Adil H. H. Bashir,Osama Y Mohammed,Gamal O. Elhassan,Gamal O. Elhassan,Salvador Harguindey,Stephan J. Reshkin,Muntaser E. Ibrahim,Cyril Rauch +13 more
TL;DR: This work suggests a wider and alternative perspective that sets the stage for a future platform in modifying drug resistance with respect to the treatment of cancer.
Journal ArticleDOI
Appropriate Chemotherapy Dosing for Obese Adult Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline
Jennifer J. Griggs,Pamela B. Mangu,Holly Anderson,Edward P. Balaban,James J. Dignam,William Hryniuk,Vicki A. Morrison,T. May Pini,Carolyn D. Runowicz,Gary L. Rosner,Michelle Shayne,Alex Sparreboom,Lara Sucheston,Gary H. Lyman +13 more
TL;DR: Full weight-based cytotoxic chemotherapy doses be used to treat obese patients with cancer, particularly when the goal of treatment is cure, and the use of fixed-dose chemotherapy is rarely justified.
Journal ArticleDOI
The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection.
John E. Mazuski,Jeffrey M. Tessier,Addison K. May,Robert G. Sawyer,Evan P. Nadler,Matthew R. Rosengart,Phillip K. Chang,Patrick J. O'Neill,Kevin P. Mollen,Jared M. Huston,Jose J. Diaz,Jose M. Prince +11 more
TL;DR: This guideline summarizes the current recommendations developed by the SIS task force on the treatment of patients who have IAI regarding risk assessment in individual patients; source control; the timing, selection, and duration of antimicrobial therapy; and suggested approaches to patients who fail initial therapy.
Journal ArticleDOI
The impact of obesity on the immune response to infection.
J. Justin Milner,Melinda A. Beck +1 more
TL;DR: More research is necessary to understand the specific aspects of immunity that are impaired and what factors are contributing to reduced immunocompetence in the obese, given that this population may not respond optimally to antimicrobial drugs and vaccination.
References
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Obesity : Preventing and managing the global epidemic
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Journal Article
A formula to estimate the approximate surface area if height and weight be known. 1916.
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Journal ArticleDOI
Obesity in children and young people: a crisis in public health.
TL;DR: The present report has been written to focus attention on the issue and to urge policy-makers to consider taking action before it is too late.
Journal ArticleDOI
Clinical calorimetry: tenth paper a formula to estimate the approximate surface area if height and weight be known
TL;DR: Means has found that the range of normal variation from the average is smaller and the apparent depression of metabolism in obesity is much less marked when the linear formula, instead of Meeh's formula, is used to determine surface area.
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