Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries
Reads0
Chats0
TLDR
Results support that VCD, but not DMBA, enhances ovotoxicity by increasing primordial to small primary follicles recruitment, and VCD is also a useful model chemical with which to elucidate signaling mechanisms involved in primordial follicle recruitment.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2009-12-01 and is currently open access. It has received 69 citations till now. The article focuses on the topics: DMBA & Folliculogenesis.read more
Citations
More filters
Journal ArticleDOI
Roles of Reactive Oxygen Species and Antioxidants in Ovarian Toxicity
TL;DR: Evidence about the potential impact of oxidative stress on the well-being of primordial, growing and preovulatory follicles, as well as oocytes and early embryos, is presented, examining cell types and molecular targets.
Journal ArticleDOI
4-vinylcyclohexene diepoxide: a model chemical for ovotoxicity.
TL;DR: The occupational chemical 4-vinylcyclohexene diepoxide (VCD) has been shown to cause selective destruction of ovarian small pre-antral (primordial and primary) follicles in rats and mice by accelerating the natural apoptotic process of atresia as mentioned in this paper.
Journal ArticleDOI
Accelerated Ovarian Failure: a novel, chemically-induced animal model of menopause
TL;DR: A new rodent model of accelerated ovarian failure (AOF) successfully replicates human perimenopause and postmenopause, including estrous acyclicity and fluctuating, followed by undetectable, estrogen levels, and allows for the dissociation of the effects of hormone levels from the effectsof aging.
Journal ArticleDOI
Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity
TL;DR: A review of studies that have been partially characterized for trichloroethylene, 7,12-dimethylbenz[a]anthracene, and 4-vinylcyclohexene to illustrate where knowledge gaps remain for chemicals that have also been established as ovotoxicants.
Journal ArticleDOI
Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster.
Amos O. Abolaji,Amos O. Abolaji,Jean Paul Kamdem,Jean Paul Kamdem,Thiago Henrique Lugokenski,Ebenezer O. Farombi,Diogo O. Souza,Élgion Lúcio da Silva Loreto,João Rocha +8 more
TL;DR: It is demonstrated that different target enzymes and genes were modified by the electrophiles VCM and VCD in the flies which suggest that the reported toxicity of VCH may be mediated by its transformation to VCM or VCD.
References
More filters
Journal ArticleDOI
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
TL;DR: One such compound, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, LY294002, completely and specifically abolished PtdIns 3-kinase activity, which may be beneficial in the treatment of proliferative diseases as well as in elucidating the biological role of the kinase in cellular proliferation and growth factor response.
Book ChapterDOI
Development of Follicles in the Mammalian Ovary
TL;DR: This chapter discusses the development of follicles in the mammalian ovary, a complex, functional miniature organ arises from the handful of cells that constitute a simple primordial follicle, a structure so small that it is invisible at the lower magnifications of a light microscope.
Journal ArticleDOI
Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a
Diego H. Castrillon,Lili Miao,Ramya Kollipara,James W. Horner,Ronald A. DePinho,Ronald A. DePinho +5 more
TL;DR: It is shown that Foxo3a–/– female mice exhibit a distinctive ovarian phenotype of global follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility, raising the possibility that accelerated follicular initiation plays a role in premature ovarian failure, a common cause of infertility and premature aging in women.
Journal ArticleDOI
Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool
Pradeep Reddy,Lian Liu,Lian Liu,Deepak Adhikari,Krishna Jagarlamudi,Singareddy Rajareddy,Yan Shen,Chun Du,Wenli Tang,Tuula Hämäläinen,Stanford L. Peng,Zi-Jian Lan,Austin J. Cooney,Ilpo Huhtaniemi,Ilpo Huhtaniemi,Kui Liu +15 more
TL;DR: The results show that the mammalian oocyte serves as the headquarters of programming of follicleactivation and that the oocyte PTEN-PI3K pathway governs follicle activation through control of initiation of oocyte growth.
Journal ArticleDOI
Gonadal expression of c-kit encoded at the W locus of the mouse
TL;DR: It was concluded that the period of expression of c-kit extends from at least as early as type A2 spermatogonia through type B sperMatogonia and into preleptotene sperMATocytes.