Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
Faustino R. Pérez-López,Vinay Pasupuleti,Edward Mezones-Holguín,Vicente A. Benites-Zapata,Priyaleela Thota,Abhishek Deshpande,Adrian V. Hernandez,Adrian V. Hernandez +7 more
TLDR
Vitamin D supplementation during pregnancy was associated with increased circulating 25(OH)D levels, birth weight, and birth length, and was not associated with other maternal and neonatal outcomes.About:
This article is published in Fertility and Sterility.The article was published on 2015-05-01 and is currently open access. It has received 235 citations till now. The article focuses on the topics: Low birth weight & Birth weight.read more
Citations
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Journal ArticleDOI
Vitamin D supplementation for women during pregnancy
TL;DR: In this paper, the effect of supplementing with vitamin D alone or in combination with calcium or other vitamins and minerals given to women during pregnancy can safely improve maternal and neonatal outcomes.
Journal ArticleDOI
Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery
TL;DR: This review addresses the current knowledge regarding maternal adaptations in mineral and skeletal homeostasis that occur during pregnancy, lactation, and post-weaning recovery and the impacts that these adaptations have on biochemical and hormonal parameters of mineralHomeostasis.
Journal ArticleDOI
Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials
Philippe Autier,Patrick Mullie,Alina Macacu,Miruna Dragomir,M. Boniol,Kim Coppens,Cécile Pizot,Mathieu Boniol +7 more
TL;DR: There remains little evidence to suggest that vitamin D supplementation has an effect on most conditions, including chronic inflammation, despite use of increased doses of vitamin D, strengthening the hypothesis that low vitamin D status is a consequence of ill health, rather than its cause.
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Vitamin D and cardiovascular disease prevention
Stefan Pilz,Nicolas Verheyen,Martin R. Grübler,Martin R. Grübler,Andreas Tomaschitz,Winfried März +5 more
TL;DR: Current available evidence does not support cardiovascular benefits or harms of vitamin D supplementation with the commonly used doses, and whether vitamin D has cardiovascular effects in individuals with overt vitamin D deficiency remains to be evaluated.
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Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data.
Lars Rejnmark,Lise Sofie Bislev,Kevin D. Cashman,Gudny Eiriksdottir,Martin Gaksch,Martin R. Grübler,Martin R. Grübler,Guri Grimnes,Vilmundur Gudnason,Paul Lips,Stefan Pilz,Natasja M. van Schoor,Mairead Kiely,Rolf Jorde +13 more
TL;DR: The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels.
References
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Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents
Bridget E. Young,Thomas McNanley,Elizabeth Cooper,Allison W. McIntyre,Frank R. Witter,Z. Leah Harris,Z. Leah Harris,Kimberly O. O'Brien +7 more
TL;DR: Optimal calcium intake and adequate maternal vitamin D status are both needed to maximize fetal bone growth to improve fetal skeletal development in pregnant adolescents.
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Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary
TL;DR: Recommendations for calcium supplementation for low‐intake pregnant women based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation are problematic logistically in low‐resource settings; excessive calcium may be harmful; and 20 weeks may be too late to alter outcomes.
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Vitamin D status during pregnancy and aspects of offspring health.
TL;DR: The evidence to date supports that women should be monitored and treated for vitamin D deficiency during pregnancy but optimal and upper limit serum 25(OH)D levels during pregnancy are not known.
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Maternal Vitamin D Status and Delivery by Cesarean
TL;DR: Maternal 25-hydroxyvitamin D was related positively to vitamin D and calcium intakes and negatively to circulating concentrations of parathyroid hormone, and vitamin D deficiency was linked to a 2-fold increased risk of cesarean for prolonged labor.
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Placental Hormones and the Control of Fetal Growth
TL;DR: It is argued that hormones produced by the placenta, including placental lactogen, placental growth hormone, and sex steroids regulate the intake, absorption, utilization and transfer of maternal nutrients to the fetus and modulate fetal and neonatal insulin production.