Journal ArticleDOI
Effects of aspect ratios of stem cells on lineage commitments with and without induction media.
TLDR
Cell shape itself is an inherent cue to regulate stem cell differentiation, let alone with or without external chemical induction factors, and the ROCK-pathway-related cell tension is responsible for the shape effect on the lineage commitment of stem cells even in growth medium.About:
This article is published in Biomaterials.The article was published on 2013-01-01. It has received 137 citations till now. The article focuses on the topics: Stem cell & Cellular differentiation.read more
Citations
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Cell–Material Interactions Revealed Via Material Techniques of Surface Patterning
TL;DR: The pertinent work sheds new insight into the cell–material interactions, and is stimulating for biomaterial design in regenerative medicine, tissue engineering, and high‐throughput detection, diagnosis, and drug screening.
Journal ArticleDOI
Nanomaterials and bone regeneration.
TL;DR: This article focused on reviewing the classification and design of nanostructured materials and nanocarrier materials for bone regeneration, their cell interaction properties, and their application in bone tissue engineering and regeneration.
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Matrix Stiffness and Nanoscale Spatial Organization of Cell-Adhesive Ligands Direct Stem Cell Fate
TL;DR: Both matrix stiffness and nanoscale spatial organization of cell-adhesive ligands direct stem cell fate, and it is revealed that RGD nanospacing affects spreading area and differentiation of rat MSCs, regardless of the hydrogel stiffness.
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Neural stem cell differentiation by electrical stimulation using a cross-linked PEDOT substrate: Expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering.
TL;DR: PEDOT PSS was, for the first time, used to elongate human NSC through the application of pulsed current, impacting on their differentiation towards neurons and contributing to longer neurites.
Journal ArticleDOI
Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation.
TL;DR: Surface stiffness and the presence of neighboring cells regulate osteogenesis in MSCs, and mature osteogenesis was low in micropatterned cells, even on stiff substrates and in multicellular clusters.
References
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Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Geometric control of cell life and death.
TL;DR: Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension.
Journal ArticleDOI
Cell shape, cytoskeletal tension, and rhoa regulate stem cell lineage commitment
TL;DR: It is demonstrated that cell shape regulates commitment of human mesenchymal stem cells to adipocyte or osteoblast fate and mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate.