Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts.
Mohammad Mirazul Islam,Roholah Sharifi,Shamina Mamodaly,Rakibul Islam,Daniel Nahra,Dina B. AbuSamra,Pui-Chuen Hui,Yashar Adibnia,Mehdi Goulamaly,Eleftherios I. Paschalis,Andrea Cruzat,Jing Kong,Per H. Nilsson,Pablo Argüeso,Tom Eirik Mollnes,James Chodosh,Claes H. Dohlman,Miguel Gonzalez-Andrades,Miguel Gonzalez-Andrades +18 more
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TLDR
Transmission electron microscopy revealed that gamma irradiated decellularized porcine cornea (G-DPC) preserved its structural integrity and radiation did not reduce the optical properties of the tissue, suggesting that GI may achieve effective tissue sterilization without affecting critical properties that are essential for corneal transplant survival.About:
This article is published in Acta Biomaterialia.The article was published on 2019-09-15 and is currently open access. It has received 43 citations till now. The article focuses on the topics: Corneal Transplant & Cornea.read more
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Designing Scaffolds for Corneal Regeneration
TL;DR: Recent advancements in materials fabrication techniques such as bioprinting, electrospinning, and different collagen alignment techniques, allow scaffolds to be generated that more accurately mimic the structure of the corneal stroma.
Journal ArticleDOI
Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications
Sina Sharifi,Mohammad Mirazul Islam,Hannah Sharifi,Rakibul Islam,Darrell J. Koza,Felisa Reyes-Ortega,David Alba-Molina,Per H. Nilsson,Per H. Nilsson,Claes H. Dohlman,Tom Eirik Mollnes,James Chodosh,Miguel Gonzalez-Andrades,Miguel Gonzalez-Andrades +13 more
TL;DR: Gelatin-methacryloyl (GELGYM) as discussed by the authors is a protein-based hydrogel that can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95
Journal ArticleDOI
Corneal Stromal Regeneration: Current Status and Future Therapeutic Potential
TL;DR: The techniques and advances that have achieved first clinical use or are close to translation for eventual therapeutic application in repairing and regenerating the corneal stroma are highlighted, while the potential of these novel therapies for achieving effective stromal regeneration is discussed.
Journal ArticleDOI
Regeneration of skeletal system with genipin crosslinked biomaterials.
Zhonghan Wang,He Liu,Wenbin Luo,Tianyang Cai,Zuhao Li,Yuzhe Liu,Weinan Gao,Qian Wan,Xianggang Wang,Jincheng Wang,Yanbing Wang,Xiaoyu Yang +11 more
TL;DR: The genipin extraction process, biosafety, and crosslinking mechanism, its potential applications, such as its use in bioprinting and serving as an antioxidant and anti-tumor agent, and the challenges ofgenipin in the clinical applications in skeletal system regeneration are presented.
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Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal.
Meihan Tao,Tianrang Ao,Xiaoyan Mao,Xinzhu Yan,Rabia Javed,Weijian Hou,Yang Wang,Cong Sun,Shuang Lin,Tianhao Yu,Qiang Ao,Qiang Ao,Qiang Ao +12 more
TL;DR: In this article, the authors systematically introduce and analyzes the mechanism, advantages, disadvantages, and applications of various sterilization and disinfection methods, discuss the factors influencing the selection of sterilization, and summarize the sterilization or disinfection method for various common decellularized matrix (dECM) and finally propose a graphical route for selecting an appropriate disinfection or sterilization method for dECM and a technical route for validating the selected method.
References
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Journal ArticleDOI
Global estimates of visual impairment: 2010.
TL;DR: It is indicated that visual impairment in 2010 is a major health issue that is unequally distributed among the WHO regions; the preventable causes are as high as 80% of the total global burden.
Journal ArticleDOI
Global Survey of Corneal Transplantation and Eye Banking
Philippe Gain,Rémy Jullienne,Zhiguo He,Mansour Aldossary,Sophie Acquart,Fabrice Cognasse,Gilles Thuret,Gilles Thuret +7 more
TL;DR: The authors' survey globally quantified the considerable shortage of corneal graft tissue, with only 1 cornea available for 70 needed, and efforts to encourage cornea donation must continue in all countries, but it is also essential to develop alternative and/or complementary solutions, such as corneAL bioengineering.
Journal ArticleDOI
Xenogeneic extracellular matrix as a scaffold for tissue reconstruction.
TL;DR: The biologic response to these xenogeneic bioscaffolds, including the immune response, is discussed herein.
Journal Article
An SV40-immortalized human corneal epithelial cell line and its characterization.
Kaoru Araki-Sasaki,Y Ohashi,T Sasabe,Kozaburo Hayashi,Hiroshi Watanabe,Yasuo Tano,Hiroshi Handa +6 more
TL;DR: The authors have established an SV40-immortalized human corneal epithelial cell line with properties similar to normal cornea-specific, 64-kD cytokeratin in addition to five major insoluble proteins.
Journal ArticleDOI
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation
Tom Eirik Mollnes,Ole-Lars Brekke,Michael Fung,Hilde Fure,Dorte Christiansen,Grethe Bergseth,Vibeke Videm,Knut Tore Lappegård,Jörg Köhl,John D. Lambris +9 more
TL;DR: A novel in vitro model using the thrombin-specific hirudin analog lepirudin as anticoagulant, which, in contrast to heparin, did not interfere with complement activation was used to study the role of complement in Escherichia coli-induced inflammatory responses.