Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial
Ana Maria Henao-Restrepo,Ira M. Longini,Matthias Egger,Matthias Egger,Natalie E. Dean,W. John Edmunds,Anton Camacho,Miles W. Carroll,Miles W. Carroll,Moussa Doumbia,Bertrand Draguez,Sophie Duraffour,Godwin Enwere,Rebecca F. Grais,Stephan Günther,Stefanie Hossmann,Mandy Kader Kondé,Souleymane Kone,Eeva Kuisma,Eeva Kuisma,Myron M. Levine,Sema Mandal,Gunnstein Norheim,Ximena Riveros,Aboubacar Soumah,Sven Trelle,Andrea S. Vicari,Conall H. Watson,Sakoba Keita,Marie Paule Kieny,John-Arne Røttingen,John-Arne Røttingen,John-Arne Røttingen +32 more
TLDR
The results of this interim analysis indicate that rVSV-ZEBOV might be highly efficacious and safe in preventing Ebola virus disease, and is most likely effective at the population level when delivered during an Ebola virus Disease outbreak via a ring vaccination strategy.About:
This article is published in The Lancet.The article was published on 2015-08-29 and is currently open access. It has received 704 citations till now. The article focuses on the topics: Ebola vaccine & Ebola virus.read more
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Immunological considerations for COVID-19 vaccine strategies.
Mangalakumari Jeyanathan,Sam Afkhami,Fiona Smaill,Matthew S. Miller,Brian D. Lichty,Zhou Xing +5 more
TL;DR: The immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies are discussed and their strengths and potential shortfalls are examined, and inferences about their chances of success are made.
Journal ArticleDOI
Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!).
Ana Maria Henao-Restrepo,Anton Camacho,Ira M. Longini,Conall H. Watson,W. John Edmunds,Matthias Egger,Matthias Egger,Miles W. Carroll,Natalie E. Dean,Ibrahima Dina Diatta,Moussa Doumbia,Bertrand Draguez,Sophie Duraffour,Godwin Enwere,Rebecca F. Grais,Stephan Günther,Pierre Stéphane Gsell,Stefanie Hossmann,Sara Sofie Viksmoen Watle,Mandy Kader Kondé,Sakoba Keita,Souleymane Kone,Eewa Kuisma,Myron M. Levine,Sema Mandal,Thomas Mauget,Gunnstein Norheim,Ximena Riveros,Aboubacar Soumah,Sven Trelle,Andrea S. Vicari,John-Arne Røttingen,Marie Paule Kieny +32 more
TL;DR: The evidence from all 117 clusters showed that no cases of Ebola virus disease occurred 10 days or more after randomisation among all immediately vaccinated contacts and contacts of contacts of recently confirmed cases in Guinea, west Africa.
Journal ArticleDOI
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Dustin Siegel,Hui Hon Chung,Edward Doerffler,Michael O'neil Hanrahan Clarke,Kwon Soo Chun,Lijun Zhang,Sean Neville,Ernest Carra,Willard Lew,Bruce Ross,Queenie Wang,Lydia Wolfe,Robert Jordan,Veronica Soloveva,John E. Knox,Jason K. Perry,Michel Perron,Kirsten M. Stray,Ona Barauskas,Joy Y. Feng,Yili Xu,Gary Lee,Arnold L. Rheingold,Adrian S. Ray,Roy Bannister,Robert G. Strickley,S. Swaminathan,William A. Lee,Sina Bavari,Tomas Cihlar,Michael K. Lo,Travis K. Warren,Richard L. Mackman +32 more
TL;DR: A robust diastereoselective synthesis provided sufficient quantities of 4b to enable preclinical efficacy in a non-human-primate EBOV challenge model and structure activity relationships established that the 1′-CN group and C-linked nucleobase were critical for optimal anti-EBOV potency and selectivity against host polymerases.
Journal ArticleDOI
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir.
TL;DR: Biochemical data indicate that the major contribution to EBOV RNA synthesis inhibition by remdesivir can be ascribed to delayed chain termination, and the long distance of five residues between the incorporated nucleotide analogue and its inhibitory effect warrant further investigation.
Journal ArticleDOI
Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations
TL;DR: The recent history of cancer immunotherapy, including the factors that led to its success, is summarized, an overview of novel drug-development considerations is provided, and three generations of immunotherapies that have been developed since 2011 are summarized to illustrate the breadth of opportunities these new generations of Immuno-oncology represent.
References
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Journal Article
R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Book
Smallpox and its eradication
TL;DR: The author worked for the smallpox eradi-cation programme in western Africa in 1962-1963 as a member of the staff of the W H O Regional Office for Africa, and joined the Smallpox Eradication unit, of which he was Chief from 1977 until 1984.
Book
Design and Analysis of Cluster Randomization Trials in Health Research
Allan Donner,Neil Klar +1 more
TL;DR: In this article, the impact of cluster randomization on the design and analysis of a trial is discussed, and the most commonly used experimental designs are the completely randomized design, the matched-pair design and the stratified design.
Journal ArticleDOI
Ebola Virus Disease in West Africa — The First 9 Months of the Epidemic and Forward Projections
TL;DR: This work analyzed a detailed subset of data on 3343 confirmed and 667 probable Ebola cases collected in Guinea, Liberia, Nigeria, and Sierra Leone as of September 14 to estimate the case fatality rate and the course of infection.
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