Journal ArticleDOI
Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin.
TLDR
The results showed that skin disruption and inflammation did not necessarily correspond to the enhancing efficiency of the enhancers, and possibly indicated that the enhancer have varied ability and mechanisms to enhance curcumin permeation.Abstract:
Curcumin is a predominant compound derived from the rhizomes of Curcuma longa L., and shows antibacterial, anti-inflammatory and antineoplastic activity. The in-vitro and in-vivo skin absorption of curcumin was investigated after application of enhancers using Wistar rat as an animal model. The enhancers selected in this study included terpenes, flavonoids and cholestanol. The irritant profiles of these enhancers were also established by transepidermal water loss (TEWL) and histological observations. Cyclic monoterpenes generally showed stronger enhancement of curcumin permeation than the other enhancers. Modulation of concentration and pretreatment duration of enhancers possibly indicated that the enhancers have varied ability and mechanisms to enhance curcumin permeation. Terpineol produced the highest TEWL values among the enhancers tested, whereas ketocholestanol produced no, or only a negligible, increase in TEWL as compared with control. The results showed that skin disruption and inflammation did not necessarily correspond to the enhancing efficiency of the enhancers.read more
Citations
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Journal ArticleDOI
Bioavailability of curcumin: problems and promises.
TL;DR: Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
Book ChapterDOI
Curcumin: The Indian solid gold
TL;DR: Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses.
Journal ArticleDOI
Curcumin, a golden spice with a low bioavailability
Angelo Siviero,Eugenia Gallo,Valentina Maggini,Luigi Gori,Alessandro Mugelli,Fabio Firenzuoli,Alfredo Vannacci +6 more
TL;DR: The aim of this review is to summarize the pharmacodynamic and pharmacokinetic characteristics of curcumin and to compare the different pharmaceutical strategies employed to increase its bioavailability.
Journal ArticleDOI
α-Terpineol, a natural monoterpene: A review of its biological properties
TL;DR: The use of α-terpineol in medicine and in the pharmaceutical industry plays an important role in therapeutic applications as an antioxidant, anticancer, anticonvulsant, antiulcer, antihypertensive, anti-nociceptive compound.
Journal ArticleDOI
Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome
TL;DR: Owing to its antioxidant and anti‐inflammatory properties, curcumin can also exert several pleiotropic effects and improve endothelial dysfunction, adipokine imbalances, and hyperuricemia which usually accompany MetS.
References
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Journal ArticleDOI
Pharmacology of Curcuma longa
TL;DR: It appears that when given orally, curcumin is far less active than after i.p. administration, and systemic effects seem to be questionable after oral application except that they occur at very low concentrations ofCurcumin, which does not exclude a local action in the gastrointestinal tract.
Journal ArticleDOI
Passive skin penetration enhancement and its quantification in vitro
TL;DR: Three different in vitro methods, specifically, classic diffusion cell studies, attenuated total-reflectance-Fourier transform infrared spectroscopy, and tape stripping in conjunction with an appropriate analytical technique, are considered, emphasizing their application to obtain quantitative values for skin transport parameters and to separate the kinetic or thermodynamic effects of an enhancement strategy.
Journal ArticleDOI
Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers
TL;DR: This study characterised a number of gels containing either HEC or Na CMC in terms of their mechanical/textural, viscoelastic and mucoadhesive properties and suggested that the information derived from these methods may be usefully combined to provide a more rational basis for the selection of polymers and their formulation as topical drug delivery systems.
Journal Article
Skin absorption enhancers.
Adrian C. Williams,B.W. Barry +1 more
TL;DR: Examples of accelerant action that support a general concept explaining enhancer activity in human skin, known as the lipid-protein-partitioning (LPP) concept are considered.
Journal ArticleDOI
Lipid-Protein-Partitioning theory of skin penetration enhancement
TL;DR: These concepts of Lipid-Protein-Partitioning theory of skin penetration enhancement are discussed, quoting examples of the three mechanisms as assessed by differential scanning calorimetry and permeation studies and relates such investigations to ideas of the molecular architecture of the stratum coraeum.