Journal ArticleDOI
Efficacy and safety of inhaled corticosteroids. New developments.
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This article is published in American Journal of Respiratory and Critical Care Medicine.The article was published on 1998-03-01. It has received 747 citations till now.read more
Citations
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Journal ArticleDOI
Neutrophilic inflammation in severe persistent asthma.
TL;DR: The role of eosinophils in asthma is confirmed but a potential role of neutrophils in more severe asthma is suggested, as well as the role of interleukin-8 and neutrophil myeloperoxidase levels, with the highest levels in severe asthma.
Journal ArticleDOI
Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition
Randy K. Bledsoe,Valerie G. Montana,Thomas B. Stanley,Chris J. Delves,Christopher J. Apolito,David D. McKee,Thomas G. Consler,Derek J. Parks,Eugene L. Stewart,Timothy M. Willson,Millard H. Lambert,John T. Moore,Kenneth H. Pearce,H. Eric Xu +13 more
TL;DR: The crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermediary factor 2 is reported to establish a framework for understanding the roles of protein-hormone and protein-protein interactions in GR signaling pathways.
Journal ArticleDOI
Significant variability in response to inhaled corticosteroids for persistent asthma
Stanley J. Szefler,Richard J. Martin,Tonya Sharp King,Homer A. Boushey,Reuben M. Cherniack,Vernon M. Chinchilli,Timothy J. Craig,Myrna Dolovich,Jeffrey M. Drazen,Joanne K. Fagan,John V. Fahy,John V. Fahy,James E. Fish,Jean G. Ford,Elliot Israel,James P. Kiley,Monica Kraft,Stephen C. Lazarus,Robert F. Lemanske,Elizabeth A. Mauger,Stephen P. Peters,Christine A. Sorkness +21 more
TL;DR: It is possible that higher doses of ICSs are necessary to manage more severe patients or to achieve goals of therapy not evaluated in this study, such as prevention of asthma exacerbations, after a 24-week, parallel, open-label, multicenter trial.
Journal ArticleDOI
Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma
George W Chalmers,Kirsten J. MacLeod,Stuart A. Little,L.J. Thomson,C. McSharry,Neil C. Thomson +5 more
TL;DR: Active cigarette smoking impairs the efficacy of short term inhaled corticosteroid treatment in mild asthma, and this finding has important implications for the management of patients with mild asthma who smoke.
Journal ArticleDOI
Histone acetylation and deacetylation: importance in inflammatory lung diseases
TL;DR: The reduction in histone deacetylase activity can be restored by theophylline, which may be able to reverse steroid resistance in chronic obstructive pulmonary disease and other inflammatory diseases.
References
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Journal ArticleDOI
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
Peter J. Barnes,Michael Karin +1 more
TL;DR: In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of lesions, thereby amplifying and perpetuating the inflammatory state.
Journal ArticleDOI
Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures
TL;DR: Measurements of bone mineral density can predict fracture risk but cannot identify individuals who will have a fracture, and a programme of screening menopausal women for osteoporosis by measuring bone density cannot be recommended.
Journal ArticleDOI
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
TL;DR: It is demonstrated that p300/CBP acetylates nucleosomes in concert with PCAF, a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyl transferases.
Journal ArticleDOI
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
TL;DR: It is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B activation in mice and cultured cells, mediated by induction of the IκBα inhibitory protein, which traps activated NF-κB in inactive cytoplasmic complexes.
Journal ArticleDOI
Bone density at various sites for prediction of hip fractures
Steven R. Cummings,Dennis M. Black,Michael C. Nevitt,Warren S. Browner,Jane A. Cauley,Kristine E. Ensrud,Harry K. Genant,L. Palermo,J. Scott,Thomas M. Vogt +9 more
TL;DR: In this article, the femoral neck bone density was measured by dual X-ray absorptiometry is a better predictor of hip fracture than measurements of other bones, including the radius or calcaneus.