Journal ArticleDOI
Electrospun non-woven nanofibrous hybrid mats based on chitosan and PLA for wound-dressing applications.
TLDR
SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus and E. coli and are promising for wound-healing applications.Abstract:
Continuous defect-free nanofibers containing chitosan (Ch) or quaternized chitosan (QCh) were successfully prepared by one-step electrospinning of Ch or QCh solutions mixed with poly[(L-lactide)-co-(D,L-lactide)] in common solvent. XPS revealed the surface chemical composition of the bicomponent electrospun mats. Crosslinked Ch- and QCh-containing nanofibers exhibited higher kill rates against bacteria S. aureus and E. coli than the corresponding solvent-cast films. SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus. The hybrid nanofibers are promising for wound-healing applications.read more
Citations
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Journal ArticleDOI
Biomedical Applications of Biodegradable Polymers
TL;DR: This review summarizes the most recent advances in the field over the past 4 years, specifically highlighting new and interesting discoveries in tissue engineering and drug delivery applications.
Journal ArticleDOI
A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology
TL;DR: In this paper, the authors provide an overview of the electrospinning (applied electric field, distance between the needle and collector and flow rate, needle diameter), solution (polymer concentration, viscosity, solvent and solution conductivity) and environmental (relativity humidity and temperature) parameters that affect the nanofibers fabrication.
Journal ArticleDOI
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Nasim Annabi,Nasim Annabi,Ali Tamayol,Ali Tamayol,Jorge Alfredo Uquillas,Jorge Alfredo Uquillas,Mohsen Akbari,Mohsen Akbari,Luiz E. Bertassoni,Luiz E. Bertassoni,Chaenyung Cha,Chaenyung Cha,Gulden Camci-Unal,Gulden Camci-Unal,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Nicholas A. Peppas,Ali Khademhosseini,Ali Khademhosseini +18 more
TL;DR: The development of advanced hydrogel with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light‐sensitive, composite, and shape‐memory hydrogels, and a number of potential applications and challenges in the utilization in regenerative medicine are reviewed.
Journal ArticleDOI
A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages
TL;DR: In this article, an overview of different types of wounds, effective parameters in wound healing and different wound dressing materials with a special emphasis paid to those prepared by electrospinning is presented.
Journal ArticleDOI
Recent advances on the development of wound dressings for diabetic foot ulcer treatment--a review.
TL;DR: This work reviews the state of the art and the most recent advances in the development of wound dressings for DFU treatment, with special emphasis given to systems employing new polymeric biomaterials, and to the latest and innovative therapeutic strategies and delivery approaches.
References
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Journal ArticleDOI
Electrospun nanofibrous structure: A novel scaffold for tissue engineering
TL;DR: A novel poly(D,L-lactide-co-glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue-engineering applications, which acts to support and guide cell growth.
Journal ArticleDOI
Electrospinning of chitosan dissolved in concentrated acetic acid solution.
TL;DR: Only chitosan of a molecular weight of 106,000 g/mol produced bead-free chitOSan nanofibers, while low- or high-molecular-weight ch itosans of 30,000 and 398,000g/mol did not.
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Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing.
Kyong Su Rho,Lim Jeong,Lim Jeong,Gene Lee,Byoung Moo Seo,Yoon Jeong Park,Seong-Doo Hong,Sangho Roh,Jaejin Cho,Won Ho Park,Won Ho Park,Byung-Moo Min +11 more
TL;DR: The results indicate that cross-linked collagen nanofibers coated with ECM proteins, particularly type I collagen, may be a good candidate for biomedical applications, such as wound dressing and scaffolds for tissue engineering.
Journal ArticleDOI
Biodegradable electrospun fibers for drug delivery
TL;DR: It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers.
Journal ArticleDOI
Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin.
TL;DR: The hydrogel was found to have a fluid uptake of 90% of its weight which would prevent the wound bed from accumulation of exudates and can maintain a moist environment over wound bed in moderate to heavily exuding wound which would enhance epithelial cell migration during the healing process.