Emerging application of metabolomics on Chinese herbal medicine for depressive disorder.
TLDR
Wang et al. as mentioned in this paper showed that Chinese herbal medicine (CHM) treatment significantly changed metabolic disorders associated with depression, promoting metabolic network reorganization through restoring of key metabolites and metabolic pathways, which may be the main mechanism basis of CHM treatment on depression.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2021-07-02 and is currently open access. It has received 2 citations till now.read more
Citations
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Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder
TL;DR: In this paper , the effect of Acanthopanax senticosus (ASH) on major depressive disorder (MDD) and potential therapeutic mechanisms was investigated using the integrated analysis of metabolomics and network pharmacology to find the key target.
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Serum metabolomic responses to aerobic exercise in rats under chronic unpredictable mild stress
TL;DR: In this article , the effects of aerobic exercise on endogenous serum metabolites in response to chronic unpredictable mild stress (CUMS) using a rat model, aiming to identify the metabolic regulatory pathways involved in the antidepressant effect resulted from a 28-day treadmill aerobic exercise intervention.
References
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Journal ArticleDOI
A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
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'metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological nmr spectroscopic data
TL;DR: Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data by using NMR data from Xenobiotica.
Journal ArticleDOI
Altered fecal microbiota composition in patients with major depressive disorder
Hai-yin Jiang,Zongxin Ling,Yong-Hua Zhang,Hongjin Mao,Zhanping Ma,Yan Yin,Weihong Wang,W.H. Wilson Tang,Zhonglin Tan,Jianfei Shi,Lanjuan Li,Bing Ruan +11 more
TL;DR: Fecal samples from 46 patients with depression are analyzed to enable a better understanding of changes in the fecal microbiota composition in such patients, showing either a predominance of some potentially harmful bacterial groups or a reduction in beneficial bacterial genera.
Journal ArticleDOI
Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism
Peng Zheng,B Zeng,Chanjuan Zhou,M Liu,Z Fang,X Xu,L Zeng,Jianjun Chen,S Fan,X Du,X Zhang,D Yang,Y Yang,H Meng,Wei-Wei Li,Narayan D. Melgiri,Julio Licinio,H Wei,Peng Xie +18 more
TL;DR: It is demonstrated that dysbiosis of the gut microbiome may have a causal role in the development of depressive-like behaviors, in a pathway that is mediated through the host’s metabolism.
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Emerging applications of metabolomics in drug discovery and precision medicine
TL;DR: This Review discusses some of the latest technological advances in metabolomics, focusing on the application of metabolomics towards uncovering the underlying causes of complex diseases, the growing role of metabolites in drug discovery and its potential effect on precision medicine.
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