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Emerging applications of metabolomics in drug discovery and precision medicine
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TLDR
This Review discusses some of the latest technological advances in metabolomics, focusing on the application of metabolomics towards uncovering the underlying causes of complex diseases, the growing role of metabolites in drug discovery and its potential effect on precision medicine.Abstract:
Metabolomics is an emerging 'omics' science involving the comprehensive characterization of metabolites and metabolism in biological systems. Recent advances in metabolomics technologies are leading to a growing number of mainstream biomedical applications. In particular, metabolomics is increasingly being used to diagnose disease, understand disease mechanisms, identify novel drug targets, customize drug treatments and monitor therapeutic outcomes. This Review discusses some of the latest technological advances in metabolomics, focusing on the application of metabolomics towards uncovering the underlying causes of complex diseases (such as atherosclerosis, cancer and diabetes), the growing role of metabolomics in drug discovery and its potential effect on precision medicine.read more
Citations
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Journal ArticleDOI
Microbiome-wide association studies link dynamic microbial consortia to disease
Jack A. Gilbert,Robert A. Quinn,Justine W. Debelius,Zhenjiang Zech Xu,James T. Morton,Neha Garg,Neha Garg,Janet K. Jansson,Pieter C. Dorrestein,Rob Knight +9 more
TL;DR: An appreciation of the complexity of interactions among the microbiome and the host's diet, chemistry and health, as well as determining the frequency of observations that are needed to capture and integrate this dynamic interface, is paramount for developing precision diagnostics and therapies based on the microbiome.
Journal ArticleDOI
NMR Spectroscopy for Metabolomics Research.
Abdul-Hamid M. Emwas,Raja Roy,Ryan T. McKay,Leonardo Tenori,Edoardo Saccenti,G. A. Nagana Gowda,Daniel Raftery,Daniel Raftery,Fatimah Alahmari,Lukasz Jaremko,Mariusz Jaremko,David S. Wishart +11 more
TL;DR: This review will highlight a number of emerging NMR techniques and technologies that are being used to strengthen its utility and overcome its inherent limitations in metabolomic applications.
Journal ArticleDOI
MetaboAnalystR: an R package for flexible and reproducible analysis of metabolomics data.
Jasmine Chong,Jianguo Xia +1 more
TL;DR: A companion R package based on the R code base of the MetaboAnalyst web server to facilitate transparent, flexible and reproducible analysis of metabolomics data.
Journal ArticleDOI
Metabolomics for Investigating Physiological and Pathophysiological Processes
TL;DR: How metabolomics is yielding important new insights into a number of important biological and physiological processes is explored, with a major focus on illustrating how metabolomics and discoveries made through metabolomics are improving the understanding of both normal physiology and the pathophysiology of many diseases.
Journal ArticleDOI
Biomarker development in the precision medicine era: lung cancer as a case study
TL;DR: Efforts at the national level of several countries to tie molecular measurement of samples to patient data via electronic medical records are the future of precision medicine research.
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