Journal ArticleDOI
Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries.
Cai Liang,Yunting Zhang,Duan Zhuo,Chun-Yin Lo,Libo Yu,Chi Wai Lau,Yiu Wa Kwan,Gary Tse,Yu Huang,Xiaoqiang Yao +9 more
TLDR
It is demonstrated that TRPC5 in endothelial cells contributes to EDC by stimulating the production of COX‐2‐linked prostanoids.About:
This article is published in Biochemical Pharmacology.The article was published on 2019-01-01. It has received 17 citations till now. The article focuses on the topics: Prostaglandin D2 & Endothelial stem cell.read more
Citations
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Journal ArticleDOI
TRPC channels: Structure, function, regulation and recent advances in small molecular probes.
Hongbo Wang,Xiaoding Cheng,Jinbin Tian,Yuling Xiao,Tian Tian,Fuchun Xu,Xuechuan Hong,Xuechuan Hong,Michael X. Zhu +8 more
TL;DR: Recent advancements in the understanding of TRPC channel regulation, structure, and discovery of novel TRPC small molecular probes over the past few years are covered, with the goal of facilitating drug discovery for the study ofTRPCs and therapeutic development.
Journal ArticleDOI
Transient Receptor Potential Canonical (TRPC) Channels: Then and Now.
TL;DR: A historical overview of the major advances in the TRPC field focusing on the role of gene knockouts and pharmacological tools is provided.
Journal ArticleDOI
Transient receptor potential (TRP) channels: Biosensors for redox environmental stimuli and cellular status.
TL;DR: The structural and molecular basis of the redox-sensing mechanisms of TRP channels in exerting various functions under physiological conditions as well as pathological conditions such as cancer malignancy are aimed at.
Journal ArticleDOI
Mechanosensitive ion channels in cell migration.
TL;DR: In this paper, a review of the Mechanosensitive (MS) ion channel families known to regulate cell migration is presented, with an emphasis on Ca2+ mediated processes and the future directions and impact of MS ion channel activity in the field of cell migration.
Journal ArticleDOI
Role of oxylipins generated from dietary PUFAs in the modulation of endothelial cell function
TL;DR: The aggregate data indicate docosahexaenoic acid-derived oxylipins consistently show beneficial effects related to key endothelial cell functions, whereas oxylIPins derived from other PUFAs exhibit both positive and negative effects.
References
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Journal ArticleDOI
Endothelial dysfunction and vascular disease
TL;DR: The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances, which are reduced in the course of vascular disease and selectively loose the pertussis toxin‐sensitive pathway for NO release which favours vasospasm, thrombosis, penetration of macrophages, cellular growth and the inflammatory reaction leading to atherosclerosis.
Journal ArticleDOI
Transient Receptor Potential Channels in the Vasculature
Scott Earley,Joseph E. Brayden +1 more
TL;DR: The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species, including sensory perception and signal transduction.
Journal ArticleDOI
Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior
Antonio Riccio,Yan Li,Jisook Moon,Kwang-Soo Kim,Kiersten S. Smith,Uwe Rudolph,Svetlana Gapon,Gui Lan Yao,Evgeny Tsvetkov,Scott J. Rodig,Ashlee Van't Veer,Edward G. Meloni,William A. Carlezon,Vadim Y. Bolshakov,David E. Clapham,David E. Clapham +15 more
TL;DR: It is shown that TRPC5(-/-) mice exhibit diminished innate fear levels in response to innately aversive stimuli, and mutant mice exhibited significant reductions in responses mediated by synaptic activation of Group I metabotropic glutamate and cholecystokinin 2 receptors in neurons of the amygdala.
Journal ArticleDOI
Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin.
TL;DR: In the aorta of SHR and aging WKY, the endothelium‐dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2.
Journal ArticleDOI
Effects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine Coronary Arteries
James K. Hennan,Jinbao Huang,Terrance D. Barrett,Edward M. Driscoll,David E. Willens,Andrew M. Park,Leslie J. Crofford,Benedict R. Lucchesi +7 more
TL;DR: The results indicate important physiological roles for COX-2–derived prostacyclin and raise concerns regarding an increased risk of acute vascular events in patients receiving COx-2 inhibitors, which may be increased in individuals with underlying inflammatory disorders.