Journal ArticleDOI
Epstein-barr virus-induced posttransplant lymphoproliferative disorders
Carlos V. Paya,John J. Fung,Michael A. Nalesnik,Elliott Kieff,Michael Green,Gregory J. Gores,Thomas M. Habermann,Russell H. Wiesner,Lode J. Swinnen,E. Steve Woodle,Jonathan S. Bromberg +10 more
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TLDR
This review summarizes the current knowledge of EBV-PTLD and, as a result of two separate international meetings on this topic, provides recommendations for future areas of study.Abstract:
Epstein-Barr virus-induced posttransplant lymphoproliferative disease (EBV-PTLD) continues to be a major complication after solid organ transplantation in high-risk patients. Despite the identification of risk factors that predispose patients to develop EBV-PTLD, limitations in our knowledge of its pathogenesis, variable criteria for establishing the diagnosis, and lack of randomized studies addressing the prevention and treatment of EBV-PTLD hamper the optimal management of this transplant complication. This review summarizes the current knowledge of EBV-PTLD and, as a result of two separate international meetings on this topic, and provides recommendations for future areas of study.read more
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Journal ArticleDOI
Infection in Solid-Organ Transplant Recipients
TL;DR: The clinician assesses a recipient’s risk of infection while considering the risk of allograft rejection, the intensity of immunosuppression, and other factors that may contribute to his or her susceptibility to infection.
Journal ArticleDOI
Epstein-Barr Virus Infection
TL;DR: The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr and has been found in tissues from other cancers, including T-cell lymphomas and Hodgkin's disease.
Journal ArticleDOI
Cancer after kidney transplantation in the United States.
TL;DR: A large number of patients in single‐center studies and incomplete ascertainment of cases in large registries suggest that cancer after kidney transplantation is a major cause of death in these patients.
Journal ArticleDOI
Recommendations for the Outpatient Surveillance of Renal Transplant Recipients
Bertram L. Kasiske,Bertram L. Kasiske,Miguel A. Vazquez,William E. Harmon,Robert S. Brown,Gabriel M. Danovitch,Robert S. Gaston,David M. Roth,John D. Scandling,Gary G. Singer +9 more
TL;DR: These guidelines are applicable to all adult and pediatric renal transplant recipients, and they cover the outpatient screening for and prevention of diseases and complications that commonly occur after renal transplantation.
Journal ArticleDOI
Post-transplant lymphoproliferative disorders.
TL;DR: Progress has been made in better understanding the pathogenesis of PTLD, and early detection strategies, such as serial measurement of EBV-DNA load in peripheral blood samples, have assisted in the identification of high-risk patients.
References
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Journal ArticleDOI
Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation.
Cliona M. Rooney,Catherine Y.C. Ng,Susan K. Loftin,Colton Smith,Congfen Li,Robert A. Krance,Malcolm K. Brenner,Helen E. Heslop +7 more
TL;DR: EBV-specific donor-type T-cell lines seem to offer safe and effective therapy for control of EBV-associated lymphoproliferation in patients with EBV reactivation after bone-marrow transplantation.
Journal ArticleDOI
Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy.
T. E. Starzl,T. E. Starzl,Kendrick A. Porter,Kendrick A. Porter,Shunzaburo Iwatsuki,Shunzaburo Iwatsuki,Rosenthal Jt,Rosenthal Jt,Byers W. Shaw,Byers W. Shaw,R.W Atchison,R.W Atchison,M. A. Nalesnik,M. A. Nalesnik,Monto Ho,Monto Ho,Griffith Bp,Griffith Bp,Thomas R. Hakala,Thomas R. Hakala,Robert L. Hardesty,Robert L. Hardesty,Ronald Jaffe,Ronald Jaffe,Henry T. Bahnson,Henry T. Bahnson +25 more
TL;DR: Post-transplant lymphomas or other lymphoproliferative lesions developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts, often without subsequent rejection of the grafts.
Journal ArticleDOI
Infusions of Donor Leukocytes to Treat Epstein-Barr Virus-Associated Lymphoproliferative Disorders after Allogeneic Bone Marrow Transplantation
Esperanza B. Papadopoulos,Marc Ladanyi,David Emanuel,Stephen Mackinnon,Farid Boulad,Matthew H. Carabasi,Hugo Castro-Malaspina,Barrett H. Childs,Alfred P. Gillio,Trudy N. Small,James W. Young,Nancy A. Kernan,Richard J. O'Reilly +12 more
TL;DR: In a small number of patients, infusions of unirradiated donor leukocytes were an effective treatment for EBV-associated lymphoproliferative disease that arose after allogeneic bone marrow transplantation.
Journal ArticleDOI
Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients.
Lode J. Swinnen,Costanzo-Nordin Mr,Susan G. Fisher,E J O'Sullivan,E J O'Sullivan,M R Johnson,M R Johnson,A L Heroux,A L Heroux,G J Dizikes,G J Dizikes,Roque Pifarré,Roque Pifarré,Richard I. Fisher,Richard I. Fisher +14 more
TL;DR: The addition of OKT3 to the immunosuppressive regimen increases the incidence of post-transplantation lymphoproliferative disorder after cardiac transplantation, and the risk increases sharply after cumulative doses greater than 75 mg.
Journal Article
The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression.
Michael A. Nalesnik,R. Jaffe,T. E. Starzl,Anthony J. Demetris,KA Porter,Burnham J,L Makowka,Ho M,Joseph Locker +8 more
TL;DR: Posttransplant lymphoproliferative disorders (PTLDs) were diagnosed in 43 patients from the Pittsburgh-Denver series between June 1980 and March 1987 and a histologic spectrum of lesions ranging from infectious mononucleosis to malignant lymphoma constitutes the entity known as PTLD.
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Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy.
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