ERβ in Breast Cancer – Onlooker, Passive Player, or Active Protector?
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TLDR
Overall, in cell-based studies, ERalpha appears to play a predominant role in cell proliferation, and ERbeta is suggested to be antiproliferative, and the potential for distinct populations of breast tumors to be identified based on ER subtype expression, and to exhibit distinct clinical behaviors, is of greatest interest.About:
This article is published in Steroids.The article was published on 2008-10-01 and is currently open access. It has received 158 citations till now. The article focuses on the topics: Estrogen receptor alpha & Estrogen receptor beta.read more
Citations
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The different roles of ER subtypes in cancer biology and therapy
TL;DR: The changes in the bioavailability of ERs in tumours promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.
Journal ArticleDOI
Anticancer activities of artemisinin and its bioactive derivatives.
TL;DR: A comprehensive discussion of the pleiotropic response in cancer cells includes growth inhibition by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness.
Journal ArticleDOI
Influence of Sex Hormones on Cancer Progression
Elizabeth Folkerd,Mitch Dowsett +1 more
TL;DR: Demonstration of the correlation of the completeness of withdrawal with clinical outcome together with direct evidence of progression from studies looking at the influence of tissue and circulating levels of sex hormones more recently in conjunction with gene expression profiles all provide compelling evidence for the involvement of steroids in the progression of disease.
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Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways.
TL;DR: C Crosstalk between growth factors and steroids in both the cytoplasm and nucleus may have a profound impact on complex biological processes such as cell growth, and may play a significant role in the treatment of steroid-dependent breast cancers.
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ERα-negative and triple negative breast cancer: Molecular features and potential therapeutic approaches
Jin-Qiang Chen,Jose Russo +1 more
TL;DR: Gaining better insights into these molecular pathways in TNBC may lead to identification of novel biomarkers and targets for development of diagnostic and therapeutic approaches for prevention and treatment of TNBC.
References
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Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
PatentDOI
DIFFERENTIAL LIGAND ACTIVATION OF ESTROGEN RECEPTORS ER$g(a) AND ER$g(b) AT AP1 SITES
Peter J. Kushner,Jan-Ake Gustafsson,George G.J.M. Kuiper,Stefan K. Nilsson,Kolja Paech,Thomas S. Scanlan,Paul W. Webb +6 more
TL;DR: In this article, a cell comprising an estrogen receptor beta (ER beta ), AP1 proteins, and a construct comprising a promoter comprising an AP1 site which regulates expression of a first reporter gene is contacted with the test compound and changes in expression levels of the reporter gene are detected indicating whether the test compounds activate transcription, inactivate transcription or have no effect at the AP1 sites.
Journal ArticleDOI
Estrogen receptor null mice: what have we learned and where will they lead us?
John F. Couse,Kenneth S. Korach +1 more
TL;DR: The recent successful generation of double knockout, or alpha beta ERKO mice of both sexes, suggests that this receptor is also not essential to survival and was most likely not a compensatory factor in the survival of the alpha ERKO.
Journal ArticleDOI
Mechanisms of Estrogen Action
Stefan Nilsson,Sari Mäkelä,Eckardt Treuter,Michel Tujague,Jane S. Thomsen,Göran Andersson,Eva Enmark,Katarina Pettersson,Margaret Warner,Jan-Åke Gustafsson +9 more
TL;DR: The role of estrogen receptors in physiology and pathology has been investigated in the past decade and it was found that there was not one but two distinct and functional estrogen receptors, now called ERα and ERβ.
Journal ArticleDOI
The multifaceted mechanisms of estradiol and estrogen receptor signaling.
TL;DR: This minireview will discuss the recent progress toward the understanding of the molecular mechanisms of estrogen signaling, focusing on the following four pathways: 1) classical ligand-dependent; 2) ligand -independent; 3) DNA binding-independent; and 4) cell-surface (nongenomic) signaling.