Journal ArticleDOI
The different roles of ER subtypes in cancer biology and therapy
TLDR
The changes in the bioavailability of ERs in tumours promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.Abstract:
By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.read more
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Signal Transduction in Cancer
Richard Sever,Joan S. Brugge +1 more
TL;DR: An examination of the PI3K-Akt and Ras-ERK pathways illustrates how such alterations dysregulate signaling in cancer and produce many of the characteristic features of tumor cells.
Journal ArticleDOI
Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study
Weiva Sieh,Martin Köbel,Teri A. Longacre,David D.L. Bowtell,David D.L. Bowtell,Anna deFazio,Marc T. Goodman,Estrid Høgdall,Suha Deen,Nicolas Wentzensen,Kirsten B. Moysich,James D. Brenton,James D. Brenton,Blaise Clarke,Usha Menon,C. Blake Gilks,Andre E. Kim,Jason Madore,Sian Fereday,Joshy George,Laura Galletta,Galina Lurie,Lynne R. Wilkens,Michael E. Carney,Pamela J. Thompson,Rayna K. Matsuno,Susanne K. Kjaer,Allan Jensen,Claus Høgdall,Kimberly R. Kalli,Brooke L. Fridley,Gary L. Keeney,Robert A. Vierkant,Julie M. Cunningham,Louise A. Brinton,Hannah P. Yang,Mark E. Sherman,Montserrat Garcia-Closas,Jolanta Lissowska,Kunle Odunsi,Carl Morrison,Shashikant Lele,Wiam Bshara,Lara Sucheston,Mercedes Jimenez-Linan,Mercedes Jimenez-Linan,Kristy Driver,Jennifer Alsop,Marie Mack,Valerie McGuire,Joseph H. Rothstein,Barry P. Rosen,Marcus Q. Bernardini,Helen Mackay,Amit M. Oza,Eva Wozniak,Elizabeth Benjamin,Aleksandra Gentry-Maharaj,Simon A. Gayther,Anna V. Tinker,Leah M Prentice,Christine Chow,Michael S. Anglesio,Sharon E. Johnatty,Georgia Chenevix-Trench,Alice S. Whittemore,Paul D.P. Pharoah,Ellen L. Goode,David G. Huntsman,David G. Huntsman,Susan J. Ramus +70 more
TL;DR: Clinical trials, stratified by subtype and biomarker status, are needed to establish whether hormone-receptor status predicts response to endocrine treatment, and whether it could guide personalised treatment for ovarian cancer.
Journal ArticleDOI
The potential health effects of dietary phytoestrogens
TL;DR: The literature overview presented in this paper illustrates that several potential health benefits of phytoestrogens have been reported but that, given the data on potential adverse health effects, the current evidence on these beneficial health effects is not so obvious that they clearly outweigh the possible health risks.
Journal ArticleDOI
The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases.
Deena Khan,S. Ansar Ahmed +1 more
TL;DR: Since estrogen has varied effects in female-predominant autoimmune diseases such as multiple sclerosis and systemic lupus erythematosus, it is mechanistically postulate the potential differential role of estrogen in these chronic debilitating diseases.
Journal ArticleDOI
Addressing the role of obesity in endometrial cancer risk, prevention, and treatment
TL;DR: The molecular mechanisms by which obesity and adipose tissue contribute to the pathogenesis of endometrial cancer are identified and the development of rational behavioral and pharmaceutical interventions aimed at reducing endometrian cancer risk, improving cancer outcomes, and preserving fertility in an increasingly younger population of patients with endometrium cancer are examined.
References
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Journal ArticleDOI
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TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
Journal ArticleDOI
Cloning of a novel receptor expressed in rat prostate and ovary.
TL;DR: It is concluded that clone 29 cDNA encodes a novel rat ER, which is suggested be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.
Journal Article
Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group
TL;DR: There have been many randomised trials of adjuvant tamoxifen among women with early breast cancer, and an updated overview of their results is presented in this paper, which approximately doubles the amount of evidence from trials of about 5 years of tamoxifier and, taking all trials together, on events occurring more than 5 years after randomisation.