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Expression of melatoninergic receptors in human placental choriocarcinoma cell lines

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TLDR
These results demonstrate, for the first time, the expression of melatonin receptors in human term placental tissues and in choriocarcinoma cells and suggest a possible paracrine/autocrine function for melatonin in human placenta.
Abstract
Lanoix D, Ouellette R, Vaillancourt C. Melatonin crosses the placenta and enters the fetal circulation. Moreover, experimental data suggest a possible influence of melatonin on placental function and fetal development in humans. To date, the expression and role of melatonin receptors in human placenta choriocarcinoma cell lines and in human term placental tissues remain to be elucidated. METHODS AND RESULTS : Results from RT-PCR, western blotting and confocal microscopy demonstrated that the (...)

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Journal ArticleDOI

Expression of MT2 Receptor in Patients with Gastric Adenocarcinoma and its Relationship with Clinicopathological Features

TL;DR: It is concluded that for the first time, the expression of MT2 receptor in gastric adenocarcinoma tissues which was in parallel with breast and colon cancer studies and high expression of this receptor in the marginal tissues indicate refractory mechanism which shows the defending role of melatonin in the GI system.
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Expression of melatonin receptor (MT1) and interaction between melatonin and estrogen in endometrial cancer cell line.

TL;DR: To determine the receptor subtypes ofmelatonin in estrogen receptor‐positive endometrial cancer cell line, Ishikawa, and the influence of melatonin on chemosensitivity.
Journal ArticleDOI

Human choriocarcinomas: placental growth factor-dependent preclinical tumor models.

TL;DR: The novel results presented here validate the importance of human choriocarcinoma cell lines and xenografts in further exploring the role of PlGF in tumor angiogenesis and for evaluating PlGF as an anti-angiogenic target, and for developing therapies that may provide clinical benefit.
Journal ArticleDOI

La melatonina reduce la respuesta de cortisol al ACTH en humanos

TL;DR: Adrenal glandswere obtained from 4 patients undergoing unilateral nephrectomy-adrenalectomy for renalcancer and expression of mRNA MT1 and MT2 melatonin receptors was measured by ReverseTranscriptase Polymerase Chain Reaction (RT-PCR).
Journal ArticleDOI

Melatonin regulates delayed embryonic development in the short-nosed fruit bat, Cynopterus sphinx.

TL;DR: It is suggested that a high circulating melatonin level has a dual contribution in retarding embryonic development in C. sphinx by impairing progesterone synthesis as well as by inhibiting progester one action by reducing expression of PGR in the utero-embryonic unit.
References
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Journal ArticleDOI

DNA sequencing with chain-terminating inhibitors

TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
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Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

TL;DR: The cloning and characterization of a high affinity receptor for melatonin from the sheep and human is reported, likely mediates the reproductive and circadian actions of melatonin in mammals.
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Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

TL;DR: The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects ofmelatonin in mammals.
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Orphan nuclear receptors: from gene to function.

TL;DR: I. Nuclear Receptors: General Concepts and Orphans in Search of a Home.
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Functional MT1 and MT2 melatonin receptors in mammals.

TL;DR: The melatonin-mediated responses elicited by activation of MT1 and MT2 native melatonin receptors are dependent on circadian time, duration and mode of exposure to endogenous or exogenous melatonin, and functional receptor sensitivity.
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