Expression of melatoninergic receptors in human placental choriocarcinoma cell lines
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TLDR
These results demonstrate, for the first time, the expression of melatonin receptors in human term placental tissues and in choriocarcinoma cells and suggest a possible paracrine/autocrine function for melatonin in human placenta.Abstract:
Lanoix D, Ouellette R, Vaillancourt C. Melatonin crosses the placenta and enters the fetal circulation. Moreover, experimental data suggest a possible influence of melatonin on placental function and fetal development in humans. To date, the expression and role of melatonin receptors in human placenta choriocarcinoma cell lines and in human term placental tissues remain to be elucidated. METHODS AND RESULTS : Results from RT-PCR, western blotting and confocal microscopy demonstrated that the (...)read more
Citations
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Extrapineal melatonin: sources, regulation, and potential functions.
Darío Acuña-Castroviejo,Germaine Escames,Carmen Venegas,María E. Díaz-Casado,Elena Lima-Cabello,Luis C. López,Sergio Rosales-Corral,Dun Xian Tan,Russel J. Reiter +8 more
TL;DR: The presence of melatonin in extrapineal organs, tissues, and fluids of mammals including humans is emphasized and information related to its peripheral production and regulation of this ubiquitously acting indoleamine is compiled.
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Melatonin—A pleiotropic, orchestrating regulator molecule
Rüdiger Hardeland,Daniel P. Cardinali,Venkatramanujam Srinivasan,D. Warren Spence,Gregory M. Brown,Seithikurippu R. Pandi-Perumal +5 more
TL;DR: Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging.
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Melatonin membrane receptors in peripheral tissues: distribution and functions.
Radomir M. Slominski,Russel J. Reiter,Natalia Schlabritz-Loutsevitch,Rennolds S. Ostrom,Andrzej Slominski +4 more
TL;DR: Melatonin receptor agonists and antagonists have an exciting future since they could define multiple mechanisms by which melatonin modulates the complexity of such a wide variety of physiological and pathological processes.
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Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology
TL;DR: Melatonin, of both pineal and placental origin, has essential functions in fetal maturation and placenta/uterine homeostasis and a number of conclusions naturally evolve from the data summarized in this review.
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Melatonin receptors: molecular pharmacology and signalling in the context of system bias
Erika Cecon,Erika Cecon,Erika Cecon,Atsuro Oishi,Atsuro Oishi,Atsuro Oishi,Ralf Jockers,Ralf Jockers,Ralf Jockers +8 more
TL;DR: Bias at the level of the receptor, by the expression of genetic receptor variants, will be discussed to show how a modified receptor function can have an effect on the risk for common diseases like type 2 diabetes in humans.
References
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TL;DR: The data indicate that the human Mel1a receptor is coupled to inhibition of forskolin-stimulated cAMP accumulation by a pertussis toxin-sensitive G protein, which potentiates the effects of PGF2α stimulation on phospholipase C activation.
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