Journal ArticleDOI
Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy.
Osama Yousef Althunibat,Amir M. Al Hroob,Mohammad H. Abukhalil,Mousa O. Germoush,May Bin-Jumah,Ayman M. Mahmoud +5 more
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TLDR
Fisetin attenuated the development of DCM via amelioration of hyperglycemia/hyperlipidemia‐mediated oxidative stress, inflammation and apoptosis in the diabetic heart through suppression of oxidative stress and boosted antioxidant defenses in the heart of diabetic rats.About:
This article is published in Life Sciences.The article was published on 2019-03-15. It has received 93 citations till now. The article focuses on the topics: Fisetin & Diabetic cardiomyopathy.read more
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Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels
TL;DR: The aim of this review is to summarize the current knowledge addressing the antidiabetic effects of dietary flavonoids and their underlying molecular mechanisms on selected pathways: Glucose transporter, hepatic enzymes, tyrosine kinase inhibitor, AMPK, PPAR, and NF-κB.
Journal ArticleDOI
Flavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NFκB) Signaling in Cardiovascular Diseases: A Mini Review.
Ker Woon Choy,Dharmani Devi Murugan,Xin Fang Leong,Razif Abas,Aspalilah Alias,Mohd Rais Mustafa +5 more
TL;DR: An update on the anti-inflammatory actions of flavonoids via inhibition of NFκB mechanism supporting the therapeutic potential of these natural compounds in various CVDs is presented.
Journal ArticleDOI
Piceatannol alleviates inflammation and oxidative stress via modulation of the Nrf2/HO-1 and NF-κB pathways in diabetic cardiomyopathy.
Hao Li,Youyang Shi,Xuliang Wang,Ping Li,Songyue Zhang,Tingting Wu,Yaoyao Yan,Yi Zhan,Yue Ren,Xing Rong,Tianhe Xia,Maoping Chu,Rongzhou Wu +12 more
TL;DR: In vivo, oral administration of PIC suppressed STZ-induced inflammation, oxidative stress hypertrophy, fibrosis and fibrosis in diabetic rats, thereby relieving cardiac dysfunction and improving both fibrosisand pathological changes in cardiac tissues of diabetic rats.
Journal ArticleDOI
Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation
TL;DR: Results revealed that fisetin treatment could markedly abate DOX-induced cardiotoxicity by alleviating cardiac dysfunction, ameliorating myocardial fibrosis, mitigating cardiac hypertrophy in rats, and attenuating ferroptosis of cardiomyocytes by reversing the decline in the GPX4 level.
Journal ArticleDOI
Effect of Propolis on Diet-Induced Hyperlipidemia and Atherogenic Indices in Mice
Nada Oršolić,Irena Landeka Jurčević,Domagoj Đikić,Dunja Rogić,Dyana Odeh,Vedran Balta,Eleonora Perak Junaković,Svjetlana Terzić,David Jutrić +8 more
TL;DR: The EEP possesses anti-hyperlipidemic and antioxidant activity and exhibits protective action on the cardiovascular system and hepatorenal functions and contributes towards the validation of the traditional use of propolis as a food supplement in aiding hyperlipidemia disorders.
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