Fluorescence-guided surgery with live molecular navigation--a new cutting edge.
Quyen T. Nguyen,Roger Y. Tsien +1 more
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TLDR
Using fluorescently labelled markers, surgical molecular navigation means that tumours and nerves can be displayed in real time intra-operatively in contrasting pseudocolours, which allows more complete tumour resection while preserving important structures.Citations
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Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy.
TL;DR: Magnetoresponsive Therapy Nohyun Lee, Dongwon Yoo, Daishun Ling,†,‡,⊥ Mi Hyeon Cho, Taeghwan H Yeon,*,†,† and Jinwoo Cheon.
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Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging
Hong-Wen Liu,Lanlan Chen,Lanlan Chen,Chengyan Xu,Zhe Li,Haiyang Zhang,Xiao-Bing Zhang,Weihong Tan +7 more
TL;DR: An overview of recent advances in small-molecule enzymatic fluorescent probes mainly during the past decade is provided, including the design strategies and applications for various enzymes in live cancer cells.
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Light in diagnosis, therapy and surgery.
TL;DR: The fundamentals of light–matter interactions are revisited, the applications of light in imaging, diagnosis, therapy and surgery are described, their clinical use is overviewed, and the promise of emerging light-based technologies are discussed.
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Biomaterials and emerging anticancer therapeutics: engineering the microenvironment
Luo Gu,David J. Mooney +1 more
TL;DR: The microenvironment is increasingly recognized to have key roles in cancer, and biomaterials provide a means to engineer microenvironments both in vitro and in vivo to study and manipulate cancer.
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Beyond the margins: real-time detection of cancer using targeted fluorophores.
Ray R. Zhang,Alexandra B. Schroeder,Joseph Grudzinski,Eben L. Rosenthal,Jason M. Warram,Anatoly Pinchuk,Kevin W. Eliceiri,John S. Kuo,Jamey P. Weichert +8 more
TL;DR: This Review highlights the latest developments in NIR fluorophores, cancer-targeting strategies, and detection instrumentation for intraoperative cancer detection, and considers the unique challenges associated with their effective application in clinical settings.
References
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Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Walter Stummer,Uwe Pichlmeier,Thomas Meinel,Otmar D. Wiestler,Friedhelm E. Zanella,Hans-Jürgen Reulen +5 more
TL;DR: Tumour fluorescence derived from 5-aminolevulinic acid enables more complete resections of contrast-enhancing tumour, leading to improved progression-free survival in patients with malignant glioma.
Journal ArticleDOI
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
Gooitzen M. van Dam,George Themelis,Lucia M. A. Crane,Niels J. Harlaar,Niels J. Harlaar,Rick G. Pleijhuis,W. Kelder,Athanasios Sarantopoulos,Johannes S. de Jong,Henriette J. G. Arts,Ate G.J. van der Zee,Joost Bart,Philip S. Low,Vasilis Ntziachristos +13 more
TL;DR: In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α–targeted fluorescent agent showcased the potential applications in patients with Ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
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What Is the Role for the Circumferential Margin in the Modern Treatment of Rectal Cancer
Iris D. Nagtegaal,Phil Quirke +1 more
TL;DR: It is demonstrated that, after neoadjuvant therapy (both radiotherapy and radiochemotherapy), the predictive value of the CRM for local recurrence is significantly higher than when no preoperative therapy has been applied and involvement is one of the key factors in rectal cancer treatment.
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Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients.
TL;DR: The usefulness of 5-ALA-induced tumor fluorescence for guiding tumor resection on postoperative magnetic resonance (MR) imaging and survival in patients who underwent surgery in the authors' department is indicated.
Journal ArticleDOI
Tumor imaging by means of proteolytic activation of cell-penetrating peptides.
TL;DR: In mice xenografted with human tumor cells secreting matrix metalloproteinases 2 and 9, ACPPs bearing a far-red-fluorescent cargo show in vivo contrast ratios of 2-3 and a 3.1-fold increase in standard uptake value for tumors relative to contralateral normal tissue or control peptides with scrambled linkers.