Journal ArticleDOI
Follitropin signal transduction: alternative splicing of the FSH receptor gene produces a dominant negative form of receptor which inhibits hormone action.
TLDR
The functional properties of an alternately spliced form of sheep testicular FSH receptor cDNA that codes for a protein similar to a previously described active receptor but differs in the carboxy terminus in sequence and is also shorter by 25 residues are studied.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1996-09-24. It has received 77 citations till now. The article focuses on the topics: Dominant Negative Receptor & Growth-hormone-releasing hormone receptor.read more
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Journal ArticleDOI
The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology.
TL;DR: This work presents a detailed description of the structure-function relationships and models of FSH-FSH Receptor interaction, and some of the mechanisms behind the interaction between the FSH and FSH receptor have been described.
Journal ArticleDOI
Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
Andrée Dierich,M. Ram Sairam,Lucia Monaco,Gian Maria Fimia,Anne Gansmuller,Marianne LeMeur,Paolo Sassone-Corsi +6 more
TL;DR: Although FSH signaling is not essential for initiating spermatogenesis, it appears to be required for adequate viability and motility of the sperms and mice lacking FSH-R are generated by homologous recombination.
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Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.
TL;DR: Clinical and experimental genetic disease models form a powerful tool for exploring the physiology and pathophysiology of gonadotropin function and provide an excellent example of the power of molecular biological approaches in the study of pathogenesis of diseases.
Journal ArticleDOI
FSH Directly Regulates Bone Mass
Li Sun,Yuanzhen Peng,Allison C. Sharrow,Allison C. Sharrow,Jameel Iqbal,Zhiyuan Zhang,Dionysios J. Papachristou,Dionysios J. Papachristou,Samir Zaidi,Ling-Ling Zhu,Beatrice B. Yaroslavskiy,Beatrice B. Yaroslavskiy,Hang Zhou,Alberta Zallone,M. Ram Sairam,T. Rajendra Kumar,Wei Bo,Jonathan Braun,Luis Cardoso-Landa,Mitchell B. Schaffler,Baljit S. Moonga,Harry C. Blair,Harry C. Blair,Mone Zaidi +23 more
TL;DR: It is suggested that high circulating FSH causes hypogonadal bone loss and that Osteoclasts and their precursors possess G(i2alpha)-coupled FSHRs that activate MEK/Erk, NF-kappaB, and Akt to result in enhanced osteoclast formation and function.
Journal ArticleDOI
Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction
TL;DR: The homozygous Ala307-Ser680 variant seems to be associated with significantly higher basal serum FSH levels and with a higher amount of FSH required for ovarian stimulation in women undergoing assisted reproduction, suggesting that the FSH receptor genotype can influence the ovarian response to FSH stimulation.