Four‐Year Weight Losses in the Look AHEAD Study: Factors Associated With Long‐Term Success
Thomas A. Wadden,Rebecca H. Neiberg,Rena R. Wing,Jeanne M. Clark,Linda M. Delahanty,James O. Hill,Jonathan Krakoff,Amy D. Otto,Donna H. Ryan,Mara Z. Vitolins +9 more
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Results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.Abstract:
This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P < 0.0001). More ILI than DSE participants lost ≥ 5% (46% vs. 25%, P < 0.0001) and ≥ 10% (23% vs. 10%, P < 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost ≥ 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.read more
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Objectively Assessed Physical Activity and Weight Loss Maintenance among Individuals Enrolled in a Lifestyle Intervention
Jessica L. Unick,Sarah A. Gaussoin,James O. Hill,John M. Jakicic,Dale S. Bond,Margareta Hellgren,Karen C. Johnson,Anne L. Peters,Mace Coday,Dalane W. Kitzman,Suzette R. Bossart,Rena R. Wing +11 more
TL;DR: To examine the relationship between objectively assessed moderate‐to‐vigorous intensity physical activity (MVPA) and 4‐year weight loss (WL) and WL maintenance among individuals with diabetes enrolled in the Look AHEAD trial, a large number of patients with diabetes were enrolled.
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Effects of meal preparation training on body weight, glycemia, and blood pressure: results of a phase 2 trial in type 2 diabetes
Kaberi Dasgupta,Kaberi Dasgupta,Samantha Hajna,Lawrence Joseph,Deborah Da Costa,Stavroula Christopoulos,Réjeanne Gougeon +6 more
TL;DR: In this article, the authors examined changes in these parameters following training in time-efficient preparation of balanced, low-energy meals combined with pedometer-based step count monitoring, and found that persistence with the program led to improvements in eating and physical activity habits, glycemia reductions, and suggestion of blood pressure lowering effects.
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Very low-energy and low-energy formula diets: Effects on weight loss, obesity co-morbidities and type 2 diabetes remission – an update on the evidence for their use in clinical practice
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References
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Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
William C. Knowler,Elizabeth Barrett-Connor,Sarah E. Fowler,Richard F. Hamman,John M. Lachin,Elizabeth A. Walker,David M. Nathan +6 more
TL;DR: In this paper, the authors compared a lifestyle intervention with metformin to prevent or delay the development of Type 2 diabetes in nondiabetic individuals. And they found that the lifestyle intervention was significantly more effective than the medication.
Journal Article
Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults : the evidence report
Book
Relapse prevention: Maintenance strategies in the treatment of addictive behaviors, 2nd ed.
TL;DR: Haug, Sorensen, Gruber, Song, Relapse Prevention for Opioid Dependence, and Wheeler, George, Stoner, Enhancing the Relapse prevention model for Sex Offenders: Adding Recidivism Risk Reduction Therapy to Target Offenders' Dynamic Risk Needs.
Journal ArticleDOI
Physical activity as an index of heart attack risk in college alumni
TL;DR: Ex-varsity athletes retained lower risk only if they maintained a high physical activity index as alumni, and peak exertion as strenuous sports play enhanced the effect of total energy expenditure.
Journal ArticleDOI
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes: One-Year Results of the Look AHEAD Trial
Mark A. Espeland,Xavier Pi-Sunyer,George L. Blackburn,Frederick L. Brancati,George A. Bray,Renee Bright,Jeanne M. Clark,Jeffrey M. Curtis,John P. Foreyt,Kathryn Graves,Steven M. Haffner,Barbara Harrison,James O. Hill,Edward S. Horton,John M. Jakicic,Robert W. Jeffery,Karen C. Johnson,Steven E. Kahn,David E. Kelley,Abbas E. Kitabchi,William C. Knowler,Cora E. Lewis,Barbara J. Maschak-Carey,Brenda Montgomery,David M. Nathan,Jennifer Patricio,Anne L. Peters,J. Bruce Redmon,Rebecca S. Reeves,Donna H. Ryan,Monika M. Safford,Brent Van Dorsten,Thomas A. Wadden,Lynne E. Wagenknecht,Jacqueline Wesche-Thobaben,Rena R. Wing,Susan Z. Yanovski +36 more
TL;DR: At 1 year, ILI resulted in clinically significant weight loss in people with type 2 diabetes and was associated with improved diabetes control and CVD risk factors and reduced medicine use in ILI versus DSE.
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