Four‐Year Weight Losses in the Look AHEAD Study: Factors Associated With Long‐Term Success
Thomas A. Wadden,Rebecca H. Neiberg,Rena R. Wing,Jeanne M. Clark,Linda M. Delahanty,James O. Hill,Jonathan Krakoff,Amy D. Otto,Donna H. Ryan,Mara Z. Vitolins +9 more
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TLDR
Results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.Abstract:
This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P < 0.0001). More ILI than DSE participants lost ≥ 5% (46% vs. 25%, P < 0.0001) and ≥ 10% (23% vs. 10%, P < 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost ≥ 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.read more
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2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society
Michael D. Jensen,Donna H. Ryan,Caroline M. Apovian,Jamy D. Ard,Anthony G. Comuzzie,Karen A. Donato,Frank B. Hu,Van S. Hubbard,John M. Jakicic,Robert F. Kushner,Catherine M. Loria,Barbara E. Millen,Cathy Nonas,F. Xavier Pi-Sunyer,June Stevens,Victor J. Stevens,Thomas A. Wadden,Bruce M. Wolfe,Susan Z. Yanovski +18 more
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2013 AHA/ACC/TOS Guideline for the Management of Overweight
Michael D. Jensen,H. Ryan,M. Apovian,Catherine M. Loria,Jamy D. Ard,Barbara E. Millen,Anthony G. Comuzzie,Cathy Nonas,Karen A. Donato,F. Xavier Pi-Sunyer,Frank B. Hu,S. Hubbard,Victor J. Stevens,John M. Jakicic,Thomas A. Wadden,Robert F. Kushner,Bruce M. Wolfe,Susan Z. Yanovski +17 more
Journal ArticleDOI
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
Michael D. Jensen,Donna H. Ryan,Caroline M. Apovian,Jamy D. Ard,Anthony G. Comuzzie,Karen A. Donato,Frank B. Hu,Van S. Hubbard,John M. Jakicic,Robert F. Kushner,Catherine M. Loria,Barbara E. Millen,Cathy Nonas,F. Xavier Pi-Sunyer,June Stevens,Victor J. Stevens,Thomas A. Wadden,Bruce M. Wolfe,Susan Z. Yanovski +18 more
TL;DR: This data indicates that overweight and obesity in adults over the age of 40 is more likely to be a risk factor for adverse events than the other factors, including smoking, diet, and physical activity.
Journal ArticleDOI
EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis
Linda Fernandes,Kåre Birger Hagen,Johannes W. J. Bijlsma,Øyvor Andreassen,Pia Christensen,Philip G. Conaghan,Michael Doherty,Rinie Geenen,Alison Hammond,Ingvild Kjeken,L. Stefan Lohmander,Hans Lund,Christian D Mallen,Tiziana Nava,Susan Oliver,Karel Pavelka,Irene A Pitsillidou,José António Raimundo Mendes da Silva,Jenny de la Torre,Gustavo Zanoli,Theodora P. M. Vliet Vlieland +20 more
TL;DR: Eleven evidence-based recommendations for the non-pharmacological core management of hip and knee OA were developed, concerning the following nine topics: assessment, general approach, patient information and education, lifestyle changes, exercise, weight loss, assistive technology and adaptations, footwear and work.
Journal ArticleDOI
American association of clinical endocrinologists and american college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity.
W. Timothy Garvey,Jeffrey I. Mechanick,Elise M. Brett,Alan J. Garber,Daniel L. Hurley,Ania M. Jastreboff,Karl Nadolsky,Rachel Pessah-Pollack,Raymond A Plodkowski +8 more
TL;DR: The final recommendations recognize that obesity is a complex, adiposity-based chronic disease, where management targets both weight-related complications and adiposity to improve overall health and quality of life.
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