Journal ArticleDOI
From structure to disease: the evolving tale of aquaporin biology
TLDR
This work states that the discovery of aquaporins has stimulated a reconsideration of membrane water permeability by investigators across a wide range of disciplines and indicates diverse roles in the regulation of water homeostasis.Abstract:
Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins — the aquaporins. These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis. The recognition of aquaporins has stimulated a reconsideration of membrane water permeability by investigators across a wide range of disciplines.read more
Citations
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Physiology of cell volume regulation in vertebrates.
TL;DR: Current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species are reviewed.
Journal ArticleDOI
Oogenesis in teleosts: How fish eggs are formed
TL;DR: Recent advances on teleost fish oocyte differentiation, maturation and ovulation are highlighted, including those involved in the degeneration and reabsorption of ovarian follicles (atresia).
Journal ArticleDOI
Structural mechanism of plant aquaporin gating
Susanna Törnroth-Horsefield,Yi Wang,Kristina Hedfalk,Urban Johanson,Maria Karlsson,Emad Tajkhorshid,Richard Neutze,Per Kjellbom +7 more
TL;DR: A molecular gating mechanism which appears conserved throughout all plant plasma membrane aquaporins is revealed.
Journal ArticleDOI
Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling
TL;DR: It is reported that the water channel Aquaporin-3 (AQP3) can facilitate the uptake of H2O2 into mammalian cells and mediate downstream intracellular signaling, and it is established that AQP3 is required for Nox-derived H 2O2 signaling upon growth factor stimulation.
Journal ArticleDOI
Vacuolar transporters and their essential role in plant metabolism
TL;DR: The tonoplast transporters are an integrated part of a complex cellular network that enables a plant to react properly to changing environmental conditions, to save nutrients and energy in times of plenty, and to maintain optimal metabolic conditions in the cytosol.
References
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Journal ArticleDOI
Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein.
TL;DR: Oocytes from Xenopus laevis microinjected with in vitro-transcribed CHIP28 RNA exhibited increased osmotic water permeability; this was reversibly inhibited by mercuric chloride, a known inhibitor of water channels, so it is likely that ChIP28 is a functional unit of membrane water channels.
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Structural determinants of water permeation through aquaporin-1.
Kazuyoshi Murata,Kaoru Mitsuoka,Teruhisa Hirai,Thomas Walz,Peter Agre,J. B. Heymann,Andreas Engel,Yoshinori Fujiyoshi +7 more
TL;DR: An atomic model of human red cell AQP1 is described, providing a possible molecular explanation to a longstanding puzzle in physiology—how membranes can be freely permeable to water but impermeable to protons.
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Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.
Geoffrey T. Manley,Miki Fujimura,Tonghui Ma,Nobuo Noshita,Ferda Filiz,Andrew W. Bollen,Pak H. Chan,Alan S. Verkman +7 more
TL;DR: It is shown that mice deficient in aquaporin-4 (AQP4), a glial membrane water channel, have much better survival than wild-type mice in a model of brain edema caused by acute water intoxication, and suggested that AQP4 inhibition may provide a new therapeutic option for reducingbrain edema in a wide variety of cerebral disorders.
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Specialized membrane domains for water transport in glial cells : high-resolution immunogold cytochemistry of aquaporin-4 in rat brain
Søren Nielsen,Erlend A. Nagelhus,Mahmood Amiry-Moghaddam,Charles W. Bourque,Peter Agre,Ole Petter Ottersen +5 more
TL;DR: The highly polarized AQP4 expression indicates that these cells are equipped with specific membrane domains that are specialized for water transport, thereby mediating the flow of water between glial cells and the cavities filled with CSF and the intravascular space.
Journal ArticleDOI
Aquaporins in the Kidney: From Molecules to Medicine
TL;DR: In conditions with water retention such as severe congestive heart failure, pregnancy, and syndrome of inappropriate antidiuretic hormone secretion, both AQP 2 expression levels and apical plasma membrane targetting are increased, suggesting a role for AQP2 in the development of water retention.