Journal ArticleDOI
Functionalization of dental implant surfaces using adhesion molecules
TLDR
It was concluded that organic coating of machined screw implant surfaces providing binding sites for integrin receptors can enhance bone implant contact and periimplant bone formation.Abstract:
The aim of the present study was to test the hypothesis that organic coating of titanium screw implants that provides binding sites for integrin receptors can enhance periimplant bone formation. Ten adult female foxhounds received experimental titanium screw implants in the mandible 3 months after removal of all premolar teeth. Four types of implants were evaluated in each animal: (1) implants with machined titanium surface, (2) implants coated with collagen I, (3) implants with collagen I and cyclic RGD peptide coating (Arg-Gly-Asp) with low RGD concentrations (100 μmol/mL), and (4) implants with collagen I and RGD coating with high RGD concentrations (1000 μmol/mL). Periimplant bone regeneration was assessed histomorphometrically after 1 and 3 months in five dogs each by measuring bone implant contact (BIC) and the volume density of the newly formed periimplant bone (BVD). After 1 month, BIC was significantly enhanced only in the group of implants coated with the higher concentration of RGD peptides (p = 0.026). Volume density of the newly formed periimplant bone was significantly higher in all implants with organic coating. No significant difference was found between collagen coating and RGD coatings. After 3 months, BIC was significantly higher in all implants with organic coating than in implants with machined surfaces. Periimplant BVD was significantly increased in all coated implants in comparison to machined surfaces also. It was concluded that organic coating of machined screw implant surfaces providing binding sites for integrin receptors can enhance bone implant contact and periimplant bone formation. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 73B: 88–96, 2005read more
Citations
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Journal ArticleDOI
Effects of implant surface coatings and composition on bone integration: a systematic review.
TL;DR: The review of the experimental surface alterations revealed that thin calcium phosphate (CaP) coating technology can solve the problems associated with thick CaP coatings, while they still improve implant bone integration compared with non-coated titanium implants.
Journal ArticleDOI
Impact of Dental Implant Surface Modifications on Osseointegration.
Ralf Smeets,PD Bernd Stadlinger,Frank Schwarz,Benedicta Beck-Broichsitter,Ole Jung,Clarissa Precht,Frank Kloss,Alexander Gröbe,Max Heiland,Tobias Ebker +9 more
TL;DR: This paper provides a comprehensive overview of surface modifications that beneficially alter the topography, hydrophilicity, and outer coating of dental implants in order to enhance osseointegration in healthy as well as in compromised bone.
Journal ArticleDOI
Demineralization–remineralization dynamics in teeth and bone
Ensanya A. Abou Neel,Anas Aljabo,Adam P Strange,Salwa Ibrahim,Melanie J. Coathup,Anne M. Young,Laurent Bozec,Vivek Mudera +7 more
TL;DR: Technologies discussed include composites with nano- and micron-sized inorganic minerals that can mimic mechanical properties of the tooth and bone in addition to promoting more natural repair of surrounding tissues.
Journal ArticleDOI
Organic–Inorganic Surface Modifications for Titanium Implant Surfaces
TL;DR: The combination of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.
Journal ArticleDOI
Influence of implant surfaces on osseointegration
Arthur B. Novaes,Sérgio Luis Scombatti de Souza,Raquel R.M. Barros,Karina Pereira,Giovanna Iezzi,Adriano Piattelli +5 more
TL;DR: The literature on dental implant surfaces is reviewed by assessing in vitro and in vivo studies to show the current perspective of implant development and the perspective of incorporating biomimetic molecules to the implant surface and their effects on bone formation and remodeling around implants are discussed.
References
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Bone regeneration around titanium dental implants in dehisced defect sites: a clinical study.
TL;DR: Surgical application of an e-PTFE membrane suggested a viable clinical method for enhancing bone formation around dental implants in patients with insufficient bone volume when placing dental implants.