Journal ArticleDOI
γ-Oryzanol-Rich Black Rice Bran Extract Enhances the Innate Immune Response
Soon Young Shin,Heon-Woong Kim,Hwan-Hee Jang,Yu-Jin Hwang,Jeong-Sook Choe,Yoongho Lim,Jung-Bong Kim,Young Han Lee +7 more
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TLDR
It is suggested that γ-oryzanol in the γORE enhances innate immune responses, and promoted the secretion of innate cytokines, interleukin-8, and CCL2, which facilitate phagocytosis by RAW264.7 cells.Abstract:
The innate immune response is an important host primary defense system against pathogens. γ-Oryzanol is one of the nutritionally important phytoceutical components in rice bran oil. The goal of this study was to investigate the effect of γ-oryzanol-rich extract from black rice bran (γORE) on the activation of the innate immune system. In this study, we show that γORE increased the expression of CD14 and Toll-like receptor 4 and enhanced the phagocytic activity of RAW264.7 macrophages. Furthermore, γORE and its active ingredient γ-oryzanol promoted the secretion of innate cytokines, interleukin-8, and CCL2, which facilitate phagocytosis by RAW264.7 cells. These findings suggest that γ-oryzanol in the γORE enhances innate immune responses.read more
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The anti-cancer activity and potential clinical application of rice bran extracts and fermentation products
TL;DR: In this article, the authors focused on the anti-cancer function, mechanisms, and potential clinical usage of rice bran extracts and fermentation products in the adjuvant therapy of cancer patients.
Journal ArticleDOI
Casticin Promotes Immune Responses, Enhances Macrophage and NK Cell Activities, and Increases Survival Rates of Leukemia BALB/c Mice.
Kuang Chi Lai,Hsu Feng Lu,Kuen-Bao Chen,Shu Ching Hsueh,Jing Gung Chung,Jing Gung Chung,Wen Wen Huang,Chia Ching Chen,Hung Sheng Shang +8 more
TL;DR: Results show that casticin did not affect animal appearances, however, it increased body weights and decreased the weights of liver and spleen, phagocytosis of spleen cells, NK cell activities and cell proliferation, andCasticin could be used as promoted immune responses in leukemia mice in vivo.
Journal ArticleDOI
Inhibition of TNFα-induced interleukin-6 gene expression by barley (Hordeum vulgare) ethanol extract in BV-2 microglia.
Ji Hye Choi,JuHwan Kim,Dong Yeong Min,Euitaek Jung,Yoongho Lim,Soon Young Shin,Young Han Lee +6 more
TL;DR: NF-κB-binding site within the IL-6 promoter region is a HVE target element involved in the inhibition of TNFα-induced IL-4 gene transcription and suppression of NF-κBs signaling in BV2 microglial cells.
Journal ArticleDOI
Diversity of Purple Rice (Oryza sativa L.) Landraces in Northern Thailand
TL;DR: In this paper, the authors examined diversity of 37 accessions of purple rice collected from farmers with InDel cytoplasm markers for subspecies differentiation, 16 SSRs markers for within and between accessions variation, and selected grain quality features, namely, anthocyanin, iron, zinc, and gamma oryzanol content, when grown together as wetland rice.
Journal ArticleDOI
Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes
Mahdi Zeinali,Soheil Abbaspour-Ravasjani,Tannaz Soltanfam,Ana Cláudia Paiva-Santos,Hossein Babaei,Francisco Veiga,Hamed Hamishehkar +6 more
TL;DR: The results suggest that GO-NEs could effectively prevent UVB-induced skin cancer and could be utilized as an innovative ingredient in cosmetics.
References
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