Journal ArticleDOI
GABA dramatically improves glucose tolerance in streptozotocin-induced diabetic rats fed with high-fat diet.
Shahla Sohrabipour,Mohammadreza Sharifi,Ardeshir Talebi,Mohammad Reza Sharifi,Nepton Soltani +4 more
TLDR
GA whose beneficial effect was comparable to that of insulin, also increased glucose infusion rate during an euglycemic clamp, and GABA could improve insulin resistance via rising GLUT4 and also decreasing the gluconeogenesis pathway and Glucagon receptor gene expression.About:
This article is published in European Journal of Pharmacology.The article was published on 2018-05-05. It has received 49 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
Citations
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Journal ArticleDOI
GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity
Ashley Untereiner,Shaaban Abdo,Alpana Bhattacharjee,Himaben Gohil,Farzaneh Pourasgari,Neke Ibeh,Mi Lai,Battsetseg Batchuluun,Anthony Wong,Nicholas Khuu,Ying Liu,Dana Al Rijjal,Neil Winegarden,Carl Virtanen,Beverley A. Orser,Over Cabrera,Gabor Varga,Jonathan V. Rocheleau,Jonathan V. Rocheleau,Feihan F. Dai,Feihan F. Dai,Michael B. Wheeler,Michael B. Wheeler +22 more
TL;DR: It is suggested that β‐cell compensation associated with prediabetes overlaps with, and negates, its proliferative effects of GABA, but does not overcome impaired glucose homeostasis associated with diet‐induced obesity.
Journal ArticleDOI
GABAergic regulation of pancreatic islet cells: Physiology and antidiabetic effects.
TL;DR: The intraislet GABAergic system is a target for the amelioration of diabetes therapy, including β‐cell survival and regeneration, and in xenotransplanted human islets, GABA therapy stimulates β‐ cell replication and insulin secretion.
Journal ArticleDOI
Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters.
Adrián Rafael Murillo-de-Ozores,María Chávez-Canales,Paola de los Heros,Gerardo Gamba,María Castañeda-Bueno +4 more
TL;DR: The understanding of WNK kinases as Cl– sensitive proteins has allowed us to better understand the mechanistic details of regulatory processes involved in diverse physiological phenomena that are reviewed here.
Journal ArticleDOI
Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes.
Matthias von Herrath,Philippe P. Pagni,Kevin L. Grove,Gustaf Christoffersson,Mads Tang-Christensen,Allan E. Karlsen,Jacob Sten Petersen +6 more
TL;DR: It is argued that a better way to describe and also tackle the lack of reproducibility of data from scientific publications is to use the term "lack of robustness," since it points toward potential solutions.
Journal ArticleDOI
Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis.
Zhiying Wang,Liangqiao Bian,Chenglin Mo,Hui Shen,Lan Juan Zhao,Kuan Jui Su,Maciej Kukula,Jauh Tzuoh Lee,Daniel W. Armstrong,Robert R. Recker,Joan M. Lappe,Lynda F. Bonewald,Hong-Wen Deng,Marco Brotto +13 more
TL;DR: In this article, the authors developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture.
References
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Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
TL;DR: The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.
Journal ArticleDOI
A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.
Journal ArticleDOI
The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model
TL;DR: Results indicated that high-fat diet combined with multiple low doses of STZ (30 mg/kg at weekly intervals for 2 weeks) proved to be a better way for developing a stable animal model of type 2 diabetes, and this new model may be suitable for pharmaceutical screening.
Journal ArticleDOI
Insulin‐associated weight gain in diabetes – causes, effects and coping strategies
David Russell-Jones,Rehman Khan +1 more
TL;DR: The novel acylated analogue, insulin detemir, appears to lack the usual propensity for causing weight gain and elucidation of the pharmacological mechanisms underlying this property might help clarify the mechanisms linking insulin with weight regulation.
Journal ArticleDOI
Modeling type 2 diabetes in rats using high fat diet and streptozotocin
TL;DR: The present review summarizes the current understanding of the metabolic profile and pathology involved in the different stages of the type 2 diabetes disease progression in humans and examines the suitability of the high‐fat diet‐fed, streptozotocin (HFD/STZ)‐treated rat model as a model of type 1 diabetes.