Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia.
Michael J. Gandal,J. Christopher Edgar,Kerstin Klook,Kerstin Klook,Kerstin Klook,Steven J. Siegel +5 more
TLDR
It is proposed that analogous signal-to-noise deficits in the flow of cortical information in preclinical models are useful targets for the development of new drugs that target the treatment-resistant symptoms of schizophrenia.About:
This article is published in Neuropharmacology.The article was published on 2012-03-01 and is currently open access. It has received 263 citations till now. The article focuses on the topics: Neurocognitive & Endophenotype.read more
Citations
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Chimeric antigen receptor-modified T cells derived from defined CD8 + and CD4 + subsets confer superior antitumor reactivity in vivo
Daniel Sommermeyer,Michael Hudecek,Michael Hudecek,Paula L. Kosasih,Tea Gogishvili,David G. Maloney,David G. Maloney,Cameron J. Turtle,Cameron J. Turtle,Stanley R. Riddell,Stanley R. Riddell,Stanley R. Riddell +11 more
TL;DR: It is shown that CAR-T-cell products generated from defined T-cell subsets can provide uniform potency compared with products derived from unselected T cells that vary in phenotypic composition.
Journal ArticleDOI
Intrinsic Coupling Modes: Multiscale Interactions in Ongoing Brain Activity
TL;DR: It is proposed that the concept of intrinsic coupling modes can provide a unifying framework for capturing the dynamics of intrinsically generated neuronal interactions at multiple spatial and temporal scales.
Journal ArticleDOI
A deep learning approach for Parkinson’s disease diagnosis from EEG signals
Shu Lih Oh,Yuki Hagiwara,U. Raghavendra,Rajamanickam Yuvaraj,N. Arunkumar,Murugappan Murugappan,U. Rajendra Acharya,U. Rajendra Acharya,U. Rajendra Acharya +8 more
TL;DR: An automated detection system for Parkinson’s disease employing the convolutional neural network (CNN) employing the thirteen-layer CNN architecture which can overcome the need for the conventional feature representation stages is proposed.
Journal Article
Pathophysiologically based treatment interventions in schizophrenia
TL;DR: In this article, the contributions of disturbances in glutamate, dopamine and GABA neurotransmission to the pathophysiology of working memory impairments in schizophrenia were investigated, and a cascade of molecular events that might link these disturbances, and argued that the molecular alterations most proximal to prefrontal dysfunction offer the most promise as targets for new drug development.
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Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy.
Lawrence S. Kegeles,Xiangling Mao,Arielle D. Stanford,Ragy R. Girgis,Najate Ojeil,Xiaoyan Xu,Roberto Gil,Mark Slifstein,Anissa Abi-Dargham,Sarah H. Lisanby,Dikoma C. Shungu +10 more
TL;DR: The first GABA concentration measurements in unmedicated patients with schizophrenia, who showed elevations in both GABA and Glx levels in the medial prefrontal cortex but not the dorsolateral prefrontal cortex, suggest possible normalization of levels with antipsychotic medication.
References
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Journal ArticleDOI
The brainweb: phase synchronization and large-scale integration.
TL;DR: It is argued that the most plausible candidate is the formation of dynamic links mediated by synchrony over multiple frequency bands.
Book
Rhythms of the brain
TL;DR: The brain's default state: self-organized oscillations in rest and sleep, and perturbation of the default patterns by experience.
Journal ArticleDOI
Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties.
TL;DR: It is demonstrated here that neurons in spatially separate columns can synchronize their oscillatory responses, which has, on average, no phase difference, depends on the spatial separation and the orientation preference of the cells and is influenced by global stimulus properties.
Journal ArticleDOI
What are the functional consequences of neurocognitive deficits in schizophrenia
TL;DR: Verbal memory and vigilance appear to be necessary for adequate functional outcome in schizophrenic patients and may prevent patients from attaining optimal adaptation and hence act as "neurocognitive rate-limiting factors."
Journal ArticleDOI
Über das Elektrenkephalogramm des Menschen
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