Journal ArticleDOI
Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response.
Marcus Odendahl,Henrik E. Mei,Bimba F. Hoyer,A.M. Jacobi,Arne Hansen,Gwendolin Muehlinghaus,Claudia Berek,Falk Hiepe,Rudi Manz,Andreas Radbruch,Thomas Dörner +10 more
TLDR
The appearance of these plasma cells in the blood indicates successful competition for survival niches in the bone marrow between newly generated plasma blasts and resident plasma cells as a fundamental mechanism for the establishment of humoral memory and its plasticity.About:
This article is published in Blood.The article was published on 2005-02-15. It has received 433 citations till now. The article focuses on the topics: Antibody & Immunoglobulin G.read more
Citations
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Fcγ receptors as regulators of immune responses
TL;DR: Recent studies addressing the multifaceted roles of FcRs for IgG (FcγRs) in the immune system are discussed and how this knowledge could be translated into novel therapeutic strategies to treat human autoimmune, infectious or malignant diseases are discussed.
Journal ArticleDOI
Human mesenchymal stem cells modulate B-cell functions
Anna Corcione,Federica Benvenuto,Elisa Ferretti,Debora Giunti,Valentina Cappiello,Francesco Cazzanti,Marco Risso,Francesca Gualandi,Giovanni Luigi Mancardi,Vito Pistoia,Antonio Uccelli +10 more
TL;DR: The results further support the potential therapeutic use of hMSCs in immune-mediated disorders, including those in which B cells play a major role.
Journal ArticleDOI
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
Jens Wrammert,Kenneth J. Smith,Joseph I. Miller,William A. Langley,Kenneth E. Kokko,Christian P. Larsen,Nai-Ying Zheng,Israel Mays,Lori Garman,Christina Helms,Judith A. James,Judith A. James,Gillian M. Air,J. Donald Capra,J. Donald Capra,Rafi Ahmed,Patrick C. Wilson,Patrick C. Wilson +17 more
TL;DR: The panel of influenza-virus-specific human mAbs allowed us to address the issue of original antigenic sin (OAS): the phenomenon where the induced antibody shows higher affinity to a previously encountered influenza virus strain compared with the virus strain present in the vaccine.
Journal ArticleDOI
The generation of antibody-secreting plasma cells.
TL;DR: The regulation of antibody production is linked to the generation and maintenance of plasmablasts and plasma cells from their B cell precursors, and the terminal differentiation of B cells can be described as a simple probabilistic process governed by a central gene-regulatory network and modified by environmental stimuli.
Journal ArticleDOI
Competence and competition : the challenge of becoming a long-lived plasma cell
Andreas Radbruch,Gwendolin Muehlinghaus,Elke Luger,Ayako Inamine,Kenneth G. C. Smith,Thomas Dörner,Falk Hiepe +6 more
TL;DR: Studies of the biology of plasma cells reveal a mechanism of intriguing simplicity and elegance that focuses memory provided by plasma cells on recently encountered pathogens while minimizing the 'fading' of memory for pathogens encountered in the distant past.
References
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Journal ArticleDOI
Immunological Memory and Protective Immunity: Understanding Their Relation
Rafi Ahmed,David Gray +1 more
TL;DR: The current understanding of the cellular basis of immune memory is reviewed and the relative contributions made to protective immunity by memory and effector T and B cells are examined.
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Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
TL;DR: It is shown that human memory B lymphocytes proliferate and differentiate into plasma cells in response to polyclonal stimuli, such as bystander T cell help and CpG DNA, which offers a means to maintain serological memory for a human lifetime.
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Humoral immunity due to long-lived plasma cells
TL;DR: A substantial fraction of plasma cells can survive and continue to secrete antibody for extended periods of time in the absence of any detectable memory B cells, demonstrating a new mechanism by which humoral immunity is maintained.
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A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells
TL;DR: A solid-phase enzyme-linked immunosorbent assay (ELISPOT) is described, which provides a useful alternative to conventional plaque-forming cell assays.
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Duration of antiviral immunity after smallpox vaccination
Erika Hammarlund,Matthew W. Lewis,Scott G. Hansen,Lisa Strelow,Jay A. Nelson,Gary J Sexton,Jon M. Hanifin,Mark K. Slifka +7 more
TL;DR: It is found that more than 90% of volunteers vaccinated 25–75 years ago still maintain substantial humoral or cellular immunity (or both) against vaccinia, the virus used to vaccinate against smallpox.