Journal ArticleDOI
Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles.
Åsa Gustafsson,Åsa Gustafsson,Sofia Jonasson,Thomas Sandström,Johnny C. Lorentzen,Anders Bucht,Anders Bucht +6 more
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TLDR
The responses to TiO2 NPs were strain-dependent, indicating that genetics play a role in both immune and airway reactivity, and the impact of genetically determined factors influencing the inflammatory reactions pinpoints the complexity of assessing health risks associated with nanoparticle exposures.About:
This article is published in Toxicology.The article was published on 2014-12-04. It has received 25 citations till now. The article focuses on the topics: Allergic inflammation.read more
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A review on potential neurotoxicity of titanium dioxide nanoparticles
TL;DR: How TiO 2 NPs interact with the brain is investigated in this review by summarizing the current researches on neurotoxicity induced by TiO2 NPs.
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Toxicological status of nanoparticles: What we know and what we don't know.
TL;DR: This review summarizes the knowledge on nanoparticles, including their various applications, routes of exposure, their potential toxicity and risks to human health.
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Inhaled nanomaterials and the respiratory microbiome: clinical, immunological and toxicological perspectives
Tuang Yeow Poh,Nur A'tikah Binte Mohamed Ali,Micheál Mac Aogáin,Mustafa Hussain Kathawala,Magdiel Inggrid Setyawati,Kee Woei Ng,Sanjay H. Chotirmall +6 more
TL;DR: The size-dependent properties of nanomaterials, their body deposition after inhalation and factors that influence their fate are reviewed and the known clinical, immunological and toxicological consequences of this relationship are summarized.
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Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles
TL;DR: The present review aims to provide a comprehensive evaluation of the toxic effects induced by TiO2 NPs in the lung, liver, stomach, intestine, kidney, spleen, brain, hippocampus, heart, blood vessels, ovary and testis of mice and rats in in vivo experiments, and evaluate their potential toxic mechanisms.
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Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease
TL;DR: Overall, more scientific knowledge exists in regards to the potential for metal nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease.
References
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Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
TL;DR: Results of older bio-kinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices.
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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Macrophage plasticity and polarization: in vivo veritas
Antonio Sica,Alberto Mantovani +1 more
TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.
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The M1 and M2 paradigm of macrophage activation: time for reassessment.
TL;DR: How cytokines and pathogen signals influence macrophages' functional phenotypes and the evidence for M1 and M2 functions is assessed and a paradigm initially based on the role of a restricted set of selected ligands in the immune response is revisited.
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Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Martin Lundqvist,Johannes Stigler,Giuliano Elia,Iseult Lynch,Tommy Cedervall,Kenneth A. Dawson +5 more
TL;DR: The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.