Journal ArticleDOI
Global longitudinal strain predicts outcome after MitraClip implantation for secondary mitral regurgitation.
Rodolfo Citro,Cesare Baldi,Patrizio Lancellotti,Angelo Silverio,Gennaro Provenza,Michele Bellino,Michele Roberto Di Muro,Generoso Mastrogiovanni,Roberta De Rosa,Gennaro Galasso,Eduardo Bossone,Pietro Giudice,Federico Piscione +12 more
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TLDR
A worse preoperative GLS predicts no LVRR and is associated with adverse long-term outcome after successful MCi for SMR, and on multivariable logistic regression analysis, GLS was the only independent predictor of composite adverse cardiac events at 2-year follow-up.Abstract:
AIM The aim of this study was to assess preoperative determinants, prevalence, and prognostic impact of left ventricular (LV) reverse remodeling (LVRR) in patients with secondary mitral regurgitation (SMR), undergoing MitraClip implantation (MCi). METHODS From March 2012 to January 2015, a total of 41 consecutive patients with moderate-to-severe SMR treated successfully with MCi were enrolled. All patients underwent clinical and echocardiographic follow-up after MCi. Global longitudinal strain (GLS) was obtained using two dimensional speckle tracking analysis. A reduction in LV end-systolic volume more than 10% compared with baseline was considered as a marker of LVRR. Patients were divided into two groups according to the presence or absence of LVRR. Cardiac events were defined as the occurrence of cardiac death, rehospitalization for worsening heart failure, and mitral valve surgery. RESULTS On univariable analysis, EuroSCORE II and GLS were associated with LVRR. On multivariable logistic regression analysis, GLS was the only independent correlate of LVRR (P = 0.004). A receiver operating characteristic curve identified a cutoff value for GLS of -9.25% (P < 0.001) associated with LVRR, with a sensitivity and specificity of 81 and 74%, respectively. New York Heart Failure Association class more than 2 after MCi, absence of LVRR after MCi, and preoperative GLS more than -9.25% were significantly correlated with adverse cardiac events at long-term follow-up. On multivariable logistic regression analysis, GLS was the only independent predictor of composite adverse cardiac events at 2-year follow-up. CONCLUSION A worse preoperative GLS predicts no LVRR and is associated with adverse long-term outcome after successful MCi for SMR.read more
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Journal ArticleDOI
Assessment of Left Ventricular Function by Echocardiography: The Case for Routinely Adding Global Longitudinal Strain to Ejection Fraction.
E. Potter,Thomas H. Marwick +1 more
TL;DR: Evidence gathered over the last decade has shown GLS to be more sensitive to left ventricular dysfunction than LVEF and to provide additional prognostic information, and there is a strong case for incorporation of GLS into clinical decision making.
Journal ArticleDOI
Big Health Data and Cardiovascular Diseases: A Challenge for Research, an Opportunity for Clinical Care.
TL;DR: A critical review of big health data for cardiovascular research is provided, focusing on the opportunities of this largely free data analytics and the challenges in its realization.
Journal ArticleDOI
MitraClip and left ventricular reverse remodelling: a strain imaging study
Konstantinos Papadopoulos,Ignatios Ikonomidis,Michael Chrissoheris,Antonios Chalapas,Panagiota Kourkoveli,John Parissis,Konstantinos Spargias +6 more
TL;DR: The purpose of this study is to identify echocardiography predictors of clinical response and reverse left ventricular remodelling in patients with functional mitral regurgitation treated with MitraClip.
Journal ArticleDOI
Transcatheter Repair of Functional Mitral Regurgitation in Heart Failure Patients - A Meta-Analysis of 23 Studies on MitraClip Implantation.
Roberta De Rosa,Angelo Silverio,Cesare Baldi,Marco Di Maio,Costantina Prota,Ilaria Radano,Julia Rey,Eva Herrmann,Rodolfo Citro,Federico Piscione,Gennaro Galasso +10 more
TL;DR: MC results in durable reductions in mitral regurgitation associated with significant clinical and echocardiographic improvements in heart failure patients, and AF negatively affects LV reverse remodeling and 1-year survival after MC treatment.
Journal ArticleDOI
Home care for heart failure: can caregiver education prevent hospital admissions? A randomized trial in primary care.
Maria Stella Padula,Gaetano D'Ambrosio,Marina Tocci,Roberto D'Amico,Federico Banchelli,Letizia Angeli,Marina Scarpa,Oreste Capelli,Claudio Cricelli,Giuseppe Boriani +9 more
TL;DR: Caregivers training for early recognition of symptoms/signs of worsening heart failure may be effective in reducing hospitalizations, although the benefit was evident only in specific patient subgroups (with persistent/permanent atrial fibrillation, age <90 years or Barthel score ≥ 50), with only a positive trend in the whole cohort.
References
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Journal ArticleDOI
Percutaneous Repair or Surgery for Mitral Regurgitation
Ted Feldman,Elyse Foster,Donald D. Glower,Saibal Kar,Michael J. Rinaldi,Peter S. Fail,Richard W. Smalling,Robert J. Siegel,Geoffrey A. Rose,Eric Engeron,Catalin Loghin,Alfredo Trento,Eric R. Skipper,Tommy Fudge,George V. Letsou,Joseph M. Massaro,Laura Mauri +16 more
TL;DR: Although percutaneous repair was less effective at reducing mitral regurgitation than conventional surgery, the procedure was associated with superior safety and similar improvements in clinical outcomes.
Journal ArticleDOI
Recommendations for the echocardiographic assessment of native valvular regurgitation: an executive summary from the European Association of Cardiovascular Imaging
Patrizio Lancellotti,Christophe Tribouilloy,Andreas Hagendorff,Bogdan A. Popescu,Thor Edvardsen,Thor Edvardsen,Luc Pierard,Luigi P. Badano,José Luis Zamorano +8 more
TL;DR: It is crucial to provide standards that aim at establishing a baseline list of measurements to be performed when assessing regurgitation, and to integrate the quantification of the regurgitations, assessment of the valve anatomy and function, as well as the consequences of valvular disease on cardiac chambers.
Journal ArticleDOI
Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge REpair Study) cohort.
Ted Feldman,Saibal Kar,Michael Rinaldi,Peter S. Fail,James B. Hermiller,Richard W. Smalling,Patrick L. Whitlow,William A. Gray,Reginald I. Low,Howard C. Herrmann,Scott Lim,Elyse Foster,Donald D. Glower,Everest Investigators +13 more
TL;DR: Percutaneous repair with the MitraClip system can be accomplished with low rates of morbidity and mortality and with acute MR reduction to < 2+ in the majority of patients, and with sustained freedom from death, surgery, or recurrent MR in a substantial proportion.
Journal ArticleDOI
Prognostic implications of global LV dysfunction: a systematic review and meta-analysis of global longitudinal strain and ejection fraction
TL;DR: There is strong evidence of the prognostic value of GLS, which appears to have superior prognosticvalue to EF for predicting major adverse cardiac events.
Journal ArticleDOI
Percutaneous Mitral Valve Interventions in the Real World: Early and 1-Year Results From the ACCESS-EU, A Prospective, Multicenter, Nonrandomized Post-Approval Study of the MitraClip Therapy in Europe
Francesco Maisano,Olaf Franzen,Stephan Baldus,Ulrich Schäfer,Jörg Hausleiter,Christian Butter,Gian Paolo Ussia,Horst Sievert,Gert Richardt,Julian D. Widder,Tiziano Moccetti,Wolfgang Schillinger +11 more
TL;DR: In the real-world, post-approval experience in Europe, patients undergoing the MitraClip therapy are high-risk, elderly patients, mainly affected by functional MR, and in this patient population, the MitRAClip procedure is effective with low rates of hospital mortality and adverse events.
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Marianna Adamo,Cosmo Godino,Cristina Giannini,Andrea Scotti,Riccardo Liga,Salvatore Curello,Claudia Fiorina,Ermanna Chiari,Giuliano Chizzola,Alessandro Abbenante,Emanuele Visco,Luca Branca,Francesca Fiorelli,Eustachio Agricola,Stefano Stella,Carlo Lombardi,Antonio Colombo,Anna Sonia Petronio,Marco Metra,Federica Ettori +19 more