Glutathione metabolism and its selective modification.
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This article is published in Journal of Biological Chemistry.The article was published on 1988-11-25 and is currently open access. It has received 1912 citations till now. The article focuses on the topics: Glutathione.read more
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Journal ArticleDOI
ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control
Graham Noctor,Christine H. Foyer +1 more
TL;DR: A detailed account of current knowledge of the biosynthesis, compartmentation, and transport of these two important antioxidants, with emphasis on the unique insights and advances gained by molecular exploration are provided.
Journal ArticleDOI
Free radicals, antioxidants and functional foods: Impact on human health
TL;DR: The present review provides a brief overview on oxidative stress mediated cellular damages and role of dietary antioxidants as functional foods in the management of human diseases.
Journal ArticleDOI
Glutathione: overview of its protective roles, measurement, and biosynthesis.
TL;DR: The purpose here is to provide a brief overview of some of the important aspects of glutathione metabolism as part of this special issue that will provide a more comprehensive review of the state of knowledge regarding this essential molecule.
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Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
John D. Hayes,Lesley I. McLellan +1 more
TL;DR: Howglutathione biosynthesis, glutathione peroxidases, glutATHione S-transferases and glutathion S-conjugate efflux pumps function in an integrated fashion to allow cellular adaption to oxidative stress is discussed.
References
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Hydroperoxide metabolism in mammalian organs.
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Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
O.W. Griffith,A. Meister +1 more
TL;DR: The findings support the conclusion that the S-alkyl moiety of the sulfoximine binds at the enzyme site that normally binds the acceptor amino acid and increases in a manner which is parallel to those of the corresponding isosteric accepter amino acid substrates, i.e. glycine, alanine, and alpha-aminobutyrate.
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Selective modification of glutathione metabolism
TL;DR: Modifications of glutathione metabolism may be achieved by administration of selective enzyme inhibitors, and also by giving compounds that increase glutATHione synthesis, which are useful in chemotherapy and radiation therapy and in protecting cells against the toxic effects of drugs, other foreign compounds, and oxygen.
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The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
TL;DR: The similarity of amino acid composition, Se content and kinetic mechanism, relative to the difference in substrate specificity, indicates that the two enzymes 'classical' glutathione peroxidase and phospholipid hydroperoxide glutathions are in some way related.
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Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation
TL;DR: EnzYMES MODIFIED BY THIOL : DISULFIDE EXCHANGE-AN OVERVIEW .