Glymphatic Dysfunction Induced Oxidative Stress and Neuro-Inflammation in Major Depression Disorders
TLDR
In this article , the authors reviewed recent advances with regard to stress-induced glymphatic system impairment and reactive oxygen species (ROS)-mediated inflammation in major depression disorder (MDD) and showed that such impairment can lead to ROS accumulation in the microenvironment, inducing cellular injury signaling and activating NLRP3 in microglia.Abstract:
Major Depression disorder (MDD) is a potentially life-threatening mental illness, however, many patients have a poor response to current treatments. Recent studies have suggested that stress- or trauma-induced oxidative stress and inflammation could be important factors involved in the development of MDD, but the mechanisms remain unclear. We showed that the glymphatic system is a recently discovered structure in the brain that may be involved in the clearance of large molecular and cell debris in extracellular space. In addition, the glymphatic system can help with the removal of reactive oxygen species (ROS) and cytokines such as IL-1β and HIF-1α. Glymphatic impairment can lead to ROS accumulation in the microenvironment, inducing cellular injury signaling and activating NLRP3 in microglia to induce inflammation and, thus, many brain diseases, including psychiatric disorders. Therefore, trauma-induced glymphatic impairment could induce oxidative stress and inflammation, and thus MDD. This paper will review recent advances with regard to stress-induced glymphatic system impairment and ROS-mediated inflammation in MDD.read more
Citations
More filters
Journal ArticleDOI
Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice
Fushun Wang,Wei Wang,Simeng Gu,Dan Qi,Nathan A. Smith,Weiguo Peng,Wei Dong,Bin-Bin Zhao,Ying Mao,Pengyu Cao,Q. Richard Lu,Lee A. Shapiro,Song Stephen Yi,Erxi Wu,Jason H. Huang +14 more
TL;DR: In this article , two distinct astrocytic Ca2+ signals in the murine barrel cortex were found to contribute to distinct sleep and arousal functions by modulating the efficacy of sensory transmission.
Journal ArticleDOI
“Mens Sana in Cute Sana”—A State of the Art of Mutual Etiopathogenetic Influence and Relevant Pathophysiological Pathways between Skin and Mental Disorders: An Integrated Approach to Contemporary Psychopathological Scenarios
Vincenzo Papa,Federica Li Pomi,Francesco Borgia,Sara Genovese,Giovanni Pioggia,Sebastiano Gangemi +5 more
TL;DR: In this paper , the authors discuss the complex network of molecular pathways that are targeted by conventional and biological pharmacological agents that appear to impact two pathological spheres that previously seemed to have little connection and clarify how these mechanisms may be useful in defining different stress-coping strategies and individual phenotypes of stress sensitivity/resistance in order to promote personalized medicine in the field of psychodermatology.
Journal ArticleDOI
Novel concepts in the pathogenesis of hydrocephalus
Journal ArticleDOI
Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases
TL;DR: In this paper , the effects of Cotinine on the α7-nicotinic acetylcholine receptors (nAChRs) and the inhibition of the toll-like receptors (TLRs) are discussed.
Journal ArticleDOI
Microglial Responses to Stress-Induced Depression: Causes and Consequences
Ruqayya Afridi,Kyoungho Suk +1 more
TL;DR: A recent review as mentioned in this paper summarizes the recent literature on possible sources of microglial inflammatory activation in animal models of chronic stress-induced depression and describes how microglia inflammatory signaling affects neuronal health and causes depressive-like behavior.
References
More filters
Journal ArticleDOI
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal.
TL;DR: This review focuses on biochemical concepts of lipidPeroxidation, production, metabolism, and signaling mechanisms of two main omega-6 fatty acids lipid peroxidation products: malondialdehyde (MDA) and, in particular, 4-hydroxy-2-nonenal (4-HNE), summarizing not only its physiological and protective function as signaling molecule stimulating gene expression and cell survival, but also its cytotoxic role inhibiting geneexpression and promoting cell death.
Journal ArticleDOI
A review of central 5-HT receptors and their function
Nicholas M. Barnes,Trevor Sharp +1 more
TL;DR: A number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction and the functional responses attributed to each receptor in the brain are reviewed.
Journal ArticleDOI
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
Journal ArticleDOI
The roles of intracellular protein-degradation pathways in neurodegeneration
TL;DR: Improving macroautophagy with drugs such as rapamycin could offer a tractable therapeutic strategy for a number of late-onset neurodegenerative diseases.
Journal ArticleDOI
The neuroactive potential of the human gut microbiota in quality of life and depression
Mireia Valles-Colomer,Mireia Valles-Colomer,Gwen Falony,Gwen Falony,Youssef Darzi,Youssef Darzi,Ettje F. Tigchelaar,Jun Wang,Jun Wang,Raul Y. Tito,Raul Y. Tito,Raul Y. Tito,Carmen Schiweck,Alexander Kurilshikov,Marie Joossens,Marie Joossens,Cisca Wijmenga,Cisca Wijmenga,Stephan Claes,Lukas Van Oudenhove,Alexandra Zhernakova,Sara Vieira-Silva,Sara Vieira-Silva,Jeroen Raes,Jeroen Raes +24 more
TL;DR: Correlation of microbiome features with host quality of life and depression identified specific taxa and microbial pathways in two independent, large population cohorts, identifying links between microbial neuroactive potential and depression.