Glymphatic System in the Central Nervous System, a Novel Therapeutic Direction Against Brain Edema After Stroke
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TLDR
The role of the glymphatic system in the formation and regression of brain edema after stroke could promote the exclusion of fluids in the brain tissue and promote the recovery of neurological function in stroke patients as discussed by the authors.Abstract:
Stroke is the destruction of brain function and structure, and is caused by either cerebrovascular obstruction or rupture. It is a disease associated with high mortality and disability worldwide. Brain edema after stroke is an important factor affecting neurologic function recovery. The glymphatic system is a recently discovered cerebrospinal fluid (CSF) transport system. Through the perivascular space and aquaporin 4 (AQP4) on astrocytes, it promotes the exchange of CSF and interstitial fluid (ISF), clears brain metabolic waste, and maintains the stability of the internal environment within the brain. Excessive accumulation of fluid in the brain tissue causes cerebral edema, but the glymphatic system plays an important role in the process of both intake and removal of fluid within the brain. The changes in the glymphatic system after stroke may be an important contributor to brain edema. Understanding and targeting the molecular mechanisms and the role of the glymphatic system in the formation and regression of brain edema after stroke could promote the exclusion of fluids in the brain tissue and promote the recovery of neurological function in stroke patients. In this review, we will discuss the physiology of the glymphatic system, as well as the related mechanisms and therapeutic targets involved in the formation of brain edema after stroke, which could provide a new direction for research against brain edema after stroke.read more
Citations
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Glymphatic Dysfunction Induced Oxidative Stress and Neuro-Inflammation in Major Depression Disorders
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References
More filters
Journal ArticleDOI
Production and circulation of cerebrospinal fluid with respect to the subarachnoid space of the optic nerve.
TL;DR: Cerebrospinal fluid is produced mainly by the choroid plexus epithelium and ependymal cells of the ventricles and flows into interconnecting chambers; namely, the cisterns and the subarachnoid spaces.
Journal Article
Effect of thrombin on blood brain barrier permeability and its mechanism.
TL;DR: Increased BBB permeability may be one of the mechanisms behind TM-induced cerebral edema, possibly leading to the opening of the blood brain barrier.
Journal Article
Bumetanide protects focal cerebral ischemia-reperfusion injury in rat.
TL;DR: Results suggest that bumetanide protects focal cerebral ischemia-reperfusion injury in rat, which might through the inhibition of NKCC1.
Journal ArticleDOI
Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression.
Zhongfang Shi,Qing Fang,Ye Chen,Lixin Xu,Min Wu,Mei Jia,Yi Lu,Xiao-Xuan Wang,Yujiao Wang,Xu Yan,Liping Dong,Fang Yuan +11 more
TL;DR: It is demonstrated that methylene blue improves brain edema and astrocyte swelling, which may be mediated by the inhibition of AQP4 expression via ERK1/2 pathway, suggesting that MB may be a potential choice for the treatment ofbrain edema.
Journal ArticleDOI
Failure of bumetanide to improve outcome after intracerebral hemorrhage in rat.
Cassandra M. Wilkinson,Brittany A. Fedor,Jasmine R. Aziz,Colby A. Nadeau,Paul S. Brar,Julia J. A. Clark,Frederick Colbourne +6 more
TL;DR: After intracerebral hemorrhage (ICH), bumetanide is safe to use in rats but does not improve functional outcome in the majority of animals and did not normalize ion concentrations after late dosing, contrary to the hypothesis.
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