Cerebral Edema Formation After Stroke: Emphasis on Blood-Brain Barrier and the Lymphatic Drainage System of the Brain.
Sichao Chen,Linqian Shao,Li Ma +2 more
Reads0
Chats0
TLDR
In this paper, the authors discuss how the cerebral lymphatic system participates in the formation of cerebral edema after stroke and summarize the pathophysiological process of cerebral EDema formation after stroke from the two directions of the BBB.Abstract:
Brain edema is a severe stroke complication that is associated with prolonged hospitalization and poor outcomes. Swollen tissues in the brain compromise cerebral perfusion and may also result in transtentorial herniation. As a physical and biochemical barrier between the peripheral circulation and the central nervous system (CNS), the blood-brain barrier (BBB) plays a vital role in maintaining the stable microenvironment of the CNS. Under pathological conditions, such as ischemic stroke, the dysfunction of the BBB results in increased paracellular permeability, directly contributing to the extravasation of blood components into the brain and causing cerebral vasogenic edema. Recent studies have led to the discovery of the glymphatic system and meningeal lymphatic vessels, which provide a channel for cerebrospinal fluid (CSF) to enter the brain and drain to nearby lymph nodes and communicate with the peripheral immune system, modulating immune surveillance and brain responses. A deeper understanding of the function of the cerebral lymphatic system calls into question the known mechanisms of cerebral edema after stroke. In this review, we first discuss how BBB disruption after stroke can cause or contribute to cerebral edema from the perspective of molecular and cellular pathophysiology. Finally, we discuss how the cerebral lymphatic system participates in the formation of cerebral edema after stroke and summarize the pathophysiological process of cerebral edema formation after stroke from the two directions of the BBB and cerebral lymphatic system.read more
Citations
More filters
Journal ArticleDOI
N-Acetyl-Aspartyl-Glutamate in Brain Health and Disease
Cecilie Morland,Kaja Nordengen +1 more
TL;DR: The main effect of NAAG occurs through increased mGluR3 activation and thereby reduced glutamate release, which is a promising treatment option for many brain disorders where glutamatergic excitotoxicity plays a role.
Journal ArticleDOI
Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model
TL;DR: It is suggested that microglial MMP-2/-9 activation-mediated BBB dysfunction contributed to dopaminergic neurodegeneration in rotenone-induced mouse PD model, providing a novel view for the mechanisms of Parkinsonism.
Journal ArticleDOI
Histone Deacetylase 3 Inhibition Decreases Cerebral Edema and Protects the Blood–Brain Barrier After Stroke
Hui-long Lu,Ryan Ashiqueali,Chin I Lin,Aashlesha Walchale,Victoria Clendaniel,Rudy Matheson,Marc Fisher,Eng H. Lo,Magdy Selim,Amjad Shehadah +9 more
TL;DR: In this article , the effects of histone deacetylase 3 (HDAC3) inhibition on cerebral edema and blood-brain barrier (BBB) leakage and explored its underlying mechanisms.
Journal ArticleDOI
Glial Cells Response in Stroke
Poonam Ankush Jadhav,Mayuri Karande,Abhishek Sarkar,Shubhrakanta Sahu,Deepaneeta Sarmah,Aishika Datta,Antra Chaudhary,Kiran Kalia,Arvind K Sharma,Xin Wang,Pallab Bhattacharya +10 more
TL;DR: The therapeutic options currently being explored and developed that primarily target glial cells and can be used as neuroprotective agents for the treatment of ischemic stroke are highlighted.
Journal ArticleDOI
Cerebral edema after ischemic stroke: Pathophysiology and underlying mechanisms
Yuhang Gu,Chen Zhou,Zhe Piao,Honghua Yuan,Huimin Jiang,Hui-ming Wei,Yifan Zhu,Guangxian Nan,Xunming Ji +8 more
TL;DR: This review discusses the classification and pathological characteristics of cerebral edema, the possible relationship of the development of cerebral Edema after ischemic stroke with aquaporin 4, the SUR1-TRPM4 channel, matrix metalloproteinase 9, microRNA, cerebral venous reflux, inflammatory reactions, and cerebral ischemia/reperfusion injury.
References
More filters
Journal ArticleDOI
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015
Haidong Wang,Mohsen Naghavi,Christine Allen,Ryan M Barber,Zulfiqar A Bhutta,Zulfiqar A Bhutta,Austin Carter,Daniel C Casey,Fiona J Charlson,Fiona J Charlson,Alan Chen,Matthew M Coates,Megan Coggeshall,Lalit Dandona,Daniel Dicker,Holly E. Erskine,Holly E. Erskine,Alize J. Ferrari,Alize J. Ferrari,Christina Fitzmaurice,Kyle J Foreman,Mohammad H Forouzanfar,Maya S Fraser,Nancy Fullman,Peter W. Gething,Ellen M Goldberg,Nicholas Graetz,Juanita A. Haagsma,Simon I. Hay,Chantal Huynh,Catherine O. Johnson,Nicholas J Kassebaum,Yohannes Kinfu,Xie Rachel Kulikoff,Michael Kutz,Hmwe H Kyu,Heidi J. Larson,Janni Leung,Janni Leung,Xiaofeng Liang,Stephen S Lim,Margaret Lind,Rafael Lozano,Neal Marquez,George A. Mensah,Joe Mikesell,Ali H. Mokdad,Meghan D. Mooney,Grant Nguyen,Elaine O. Nsoesie,David M. Pigott,Christine Pinho,Gregory A. Roth,Joshua A. Salomon,Logan Sandar,Naris Silpakit,Amber Sligar,Reed J D Sorensen,Jeffrey D Stanaway,Caitlyn Steiner,Stephanie Teeple,Bernadette Thomas,Christopher Troeger,Amelia VanderZanden,Stein Emil Vollset,Valentine Wanga,Harvey Whiteford,Harvey Whiteford,Timothy M. Wolock,Leo Zoeckler,Kalkidan Hassen Abate,Cristiana Abbafati,Kaja Abbas,Foad Abd-Allah,Semaw Ferede Abera,Daisy M X Abreu,Laith J. Abu-Raddad,Gebre Yitayih Abyu,Tom Achoki,Ademola Lukman Adelekan,Zanfina Ademi,Zanfina Ademi,Arsène Kouablan Adou,Jose C. Adsuar,Kossivi Agbelenko Afanvi,Ashkan Afshin,Emilie Agardh,Arnav Agarwal,Anurag Agrawal,Aliasghar Ahmad Kiadaliri,Aliasghar Ahmad Kiadaliri,Oluremi N Ajala,Ali S. Akanda,Rufus Akinyemi,Rufus Akinyemi,Tomi Akinyemiju,Nadia Akseer,Faris Lami,Samer Alabed,Ziyad Al-Aly,Khurshid Alam,Noore Alam,Deena Alasfoor,Saleh F. Aldhahri,Robert W Aldridge,Miguel Angel Alegretti,Alicia Aleman,Zewdie Aderaw Alemu,Lily Alexander,Samia Alhabib,Raghib Ali,Ala'a Alkerwi,François Alla,Peter Allebeck,Rajaa Al-Raddadi,Ubai Alsharif,Khalid A Altirkawi,Elena Alvarez Martin,Nelson Alvis-Guzman,Azmeraw T. Amare,Adeladza Kofi Amegah,Emmanuel A. Ameh,Heresh Amini,Heresh Amini,Walid Ammar,Stephen M. Amrock,Hjalte Holm Andersen,Benjamin O. Anderson,Gregory M Anderson,Carl Abelardo T. Antonio,Atsede Fantahun Aregay,Johan Ärnlöv,Johan Ärnlöv,Valentina Arsić Arsenijević,Al Artaman,Hamid Asayesh,Rana J. Asghar,Suleman Atique,Euripide Frinel G Arthur Avokpaho,Ashish Awasthi,Peter Azzopardi,Umar Bacha,Alaa Badawi,Maria Cecilia Bahit,Kalpana Balakrishnan,Amitava Banerjee,Aleksandra Barac,Suzanne Barker-Collo,Till Bärnighausen,Till Bärnighausen,Till Bärnighausen,Lars Barregard,Lope H Barrero,Arindam Basu,Sanjay Basu,Yibeltal Tebekaw Bayou,Shahrzad Bazargan-Hejazi,Shahrzad Bazargan-Hejazi,Shahrzad Bazargan-Hejazi,Justin Beardsley,Neeraj Bedi,Ettore Beghi,Haileeyesus Adamu Belay,Brent Bell,Michelle L. Bell,Aminu K. Bello,Derrick A Bennett,Isabela M. Benseñor,Adugnaw Berhane,Eduardo Bernabé,Balem Demtsu Betsu,Addisu Shunu Beyene,Neeraj Bhala,Neeraj Bhala,Ashish Bhalla,Sibhatu Biadgilign,Boris Bikbov,Aref A. Bin Abdulhak,Brian J. Biroscak,Brian J. Biroscak,Stan Biryukov,Espen Bjertness,Jed D. Blore,Christopher D. Blosser,Megan Bohensky,Rohan Borschmann,Dipan Bose,Rupert R A Bourne,Michael Brainin,Carol Brayne,Alexandra Brazinova,Nicholas J K Breitborde,Hermann Brenner,Jerry D. Brewer,Alexandria Brown,J Brown,Traolach S. Brugha,Geoffrey Buckle,Zahid A Butt,Bianca Calabria,Bianca Calabria,Ismael R. Campos-Nonato,Julio Cesar Campuzano,Jonathan R. Carapetis,Rosario Cárdenas,David O. Carpenter,Juan Jesus Carrero,Carlos A Castañeda-Orjuela,Jacqueline Castillo Rivas,Ferrán Catalá-López,Ferrán Catalá-López,Fiorella Cavalleri,Kelly Cercy,Jorge Cerdá,Wanqing Chen,Adrienne Chew,Peggy Pei-Chia Chiang,Mirriam Chibalabala,Chioma Ezinne Chibueze,Odgerel Chimed-Ochir,Vesper Hichilombwe Chisumpa,Vesper Hichilombwe Chisumpa,Jee-Young Jasmine Choi,Rajiv Chowdhury,Hanne Christensen,Devasahayam J. Christopher,Liliana G Ciobanu,Massimo Cirillo,Aaron J Cohen,Valentina Colistro,Mercedes Colomar,Samantha M. Colquhoun,Cyrus Cooper,Leslie T. Cooper,Monica Cortinovis,Benjamin C Cowie,John A. Crump,James Damsere-Derry,Hadi Danawi,Rakhi Dandona,Farah Daoud,Sarah C. Darby,Paul I. Dargan,José Neves,Gail Davey,Adrian Davis,Dragos Virgil Davitoiu,E Filipa de Castro,Pieter de Jager,Diego De Leo,Louisa Degenhardt,Robert P Dellavalle,Kebede Deribe,Kebede Deribe,Amare Deribew,Amare Deribew,Samath D Dharmaratne,Preet K Dhillon,Cesar Diaz-Torne,Eric L. Ding,Kadine Priscila Bender dos Santos,Edem Dossou,Tim Driscoll,Leilei Duan,Manisha Dubey,Bruce Bartholow Duncan,Richard G. Ellenbogen,Christian Lycke Ellingsen,Iqbal R. F. Elyazar,Aman Yesuf Endries,Sergey Petrovich Ermakov,Babak Eshrati,Alireza Esteghamati,Kara Estep,Imad D A Faghmous,Saman Fahimi,Emerito Jose A. Faraon,Talha Farid,Carla Sofia e Sa Farinha,André Faro,Maryam S. Farvid,Maryam S. Farvid,Farshad Farzadfar,Valery L. Feigin,Seyed-Mohammad Fereshtehnejad,Jefferson G Fernandes,João C. Fernandes,Florian Fischer,Joseph R Fitchett,Abraham D. Flaxman,Nataliya Foigt,F Gerry R Fowkes,Elisabeth Barboza França,Richard C. Franklin,Joseph Friedman,Joseph Frostad,Thomas Fürst,Neal D. Futran,Neal D. Futran,Seana L. Gall,Ketevan Gambashidze,Amiran Gamkrelidze,Parthasarathi Ganguly,Fortuné Gbètoho Gankpé,Teshome Gebre,TT Gebrehiwot,Amanuel Tesfay Gebremedhin,Amanuel Tesfay Gebremedhin,Alemseged Aregay Gebru,Johanna M. Geleijnse,Bradford D. Gessner,Aloke Gopal Ghoshal,Katherine B Gibney,Richard F. Gillum,Stuart Gilmour,Ababi Zergaw Giref,Maurice Giroud,Melkamu Dedefo Gishu,Giorgia Giussani,Elizabeth Glaser,William W Godwin,Héctor Gómez-Dantés,Philimon Gona,Amador Goodridge,Sameer Vali Gopalani,Richard A. Gosselin,Carolyn C. Gotay,Atsushi Goto,Hebe N. Gouda,Felix Greaves,Harish Chander Gugnani,Rahul Gupta,Rajeev Gupta,Vipin Gupta,Reyna A Gutiérrez,Nima Hafezi-Nejad,Demewoz Haile,Alemayehu Hailu,Alemayehu Hailu,Gessessew Bugssa Hailu,Yara A. Halasa,Randah R. Hamadeh,Samer Hamidi,Jamie Hancock,Alexis J Handal,Graeme J. Hankey,Yuantao Hao,Hilda L Harb,Sivadasanpillai Harikrishnan,Josep Maria Haro,Rasmus Havmoeller,Susan R. Heckbert,Ileana Heredia-Pi,Pouria Heydarpour,Henk B M Hilderink,Hans W. Hoek,Robert S. Hogg,Masako Horino,Nobuyuki Horita,H. Dean Hosgood,Peter J. Hotez,Damian G Hoy,Mohamed Hsairi,Aung Soe Htet,Maung Maung Than Htike,Guoqing Hu,Cheng Huang,Hsiang Huang,Laetitia Huiart,Abdullatif Husseini,Inge Huybrechts,Inge Huybrechts,Grace H. Huynh,Kim Moesgaard Iburg,Kaire Innos,Manami Inoue,Veena R. Iyer,Troy Jacobs,Kathryn H. Jacobsen,Nader Jahanmehr,Mihajlo Jakovljevic,Peter James,Mehdi Javanbakht,Sudha Jayaraman,Achala Upendra Jayatilleke,Panniyammakal Jeemon,Paul N. Jensen,Vivekanand Jha,Guohong Jiang,Ying Jiang,Tariku Jibat,Tariku Jibat,Aida Jimenez-Corona,Jost B. Jonas,T.K. Joshi,Zubair Kabir,Ritul Kamal,Haidong Kan,Surya Kant,André Karch,Corine Karema,Chante Karimkhani,Dimitris Karletsos,Ganesan Karthikeyan,Amir Kasaeian,Amir Kasaeian,Marzieh Katibeh,Anil Kaul,Norito Kawakami,Jeanne Françoise Kayibanda,Peter Njenga Keiyoro,Laura Kemmer,Andrew H. Kemp,Andrew H. Kemp,Andre Pascal Kengne,Andre Pascal Kengne,Andre Keren,Maia Kereselidze,Chandrasekharan Nair Kesavachandran,Yousef Khader,Ibrahim A Khalil,Abdur Rahman Khan,Ejaz Ahmad Khan,Young-Ho Khang,Sahil Khera,Tawfik Ahmed Muthafer Khoja,Christian Kieling,Daniel Kim,Yun Jin Kim,Yun Jin Kim,Brett M. Kissela,Niranjan Kissoon,Luke D. Knibbs,Ann Kristin Knudsen,Yoshihiro Kokubo,Dhaval Kolte,Jacek A Kopec,Soewarta Kosen,Parvaiz A Koul,Ai Koyanagi,Norun Hjertager Krog,Barthelemy Kuate Defo,Burcu Kucuk Bicer,Andreas A Kudom,Ernst J Kuipers,Veena S. Kulkarni,G Anil Kumar,Gene F. Kwan,Aparna Lal,Dharmesh Kumar Lal,Ratilal Lalloo,Tea Lallukka,Hilton Lam,Jennifer O Lam,Sinead Langan,Van C. Lansingh,Anders Larsson,Dennis Odai Laryea,Asma Abdul Latif,Alicia Elena Beatriz Lawrynowicz,James Leigh,Miriam Levi,Yongmei Li,M. Patrice Lindsay,Steven E. Lipshultz,Steven E. Lipshultz,Patrick Liu,Shiwei Liu,Yang Liu,Yang Liu,Loon-Tzian Lo,Giancarlo Logroscino,Paulo A. Lotufo,Robyn M. Lucas,Raimundas Lunevicius,Raimundas Lunevicius,Ronan A Lyons,Stefan Ma,Vasco Manuel Pedro Machado,Mark T Mackay,Jennifer H MacLachlan,Hassan Magdy Abd El Razek,Mohammed Magdy,Abd El Razek,Marek Majdan,Azeem Majeed,Reza Malekzadeh,Wondimu Ayele Manamo,John Mandisarisa,Srikanth Mangalam,Chabila C Mapoma,Wagner Marcenes,David J. Margolis,Gerard R. Martin,Jose Martinez-Raga,Jose Martinez-Raga,Melvin Barrientos Marzan,Felix Masiye,Felix Masiye,Amanda J. Mason-Jones,João Massano,Richard Matzopoulos,Richard Matzopoulos,Bongani M. Mayosi,Stephen T. McGarvey,John J. McGrath,Martin McKee,Brian J. McMahon,Peter A. Meaney,Peter A. Meaney,Alem Mehari,Man Mohan Mehndiratta,Fabiola Mejía-Rodríguez,Alemayehu B. Mekonnen,Alemayehu B. Mekonnen,Yohannes Adama Melaku,Peter Memiah,Ziad A. Memish,Walter Mendoza,Atte Meretoja,Tuomo J. Meretoja,Tuomo J. Meretoja,Francis Apolinary Mhimbira,Renata Micha,Anoushka Millear,Ted R. Miller,Ted R. Miller,Mojde Mirarefin,Awoke Misganaw,Charles N Mock,Karzan Abdulmuhsin Mohammad,Alireza Mohammadi,Shafiu Mohammed,Shafiu Mohammed,Viswanathan Mohan,Glen Mola,Lorenzo Monasta,Julio Cesar Montañez Hernandez,Pablo Montero,Marcella Montico,Thomas J. Montine,Maziar Moradi-Lakeh,Lidia Morawska,Katherine Majzoub Morgan,Rintaro Mori,Dariush Mozaffarian,Ulrich O Mueller,Gudlavalleti V S Murthy,Srinivas Murthy,Kamarul Imran Musa,Jean B. Nachega,Jean B. Nachega,Gabriele Nagel,Kovin Naidoo,Nitish Naik,Luigi Naldi,Vinay Nangia,Denis Nash,Chakib Nejjari,Subas Neupane,Charles R. Newton,John N Newton,Marie Ng,Frida Namnyak Ngalesoni,Jean de Dieu Ngirabega,Quyen Nguyen,Muhammad Imran Nisar,Patrick Martial Nkamedjie Pete,Marika Nomura,Ole Frithjof Norheim,Paul Norman,Bo Norrving,Luke Nyakarahuka,Felix Akpojene Ogbo,Takayoshi Ohkubo,Foluke Adetola Ojelabi,Pedro R. Olivares,Bolajoko O. Olusanya,Jacob Olusegun Olusanya,John Nelson Opio,Eyal Oren,Alberto Ortiz,Majdi Osman,Erika Ota,Raziye Özdemir,Mahesh Pa,Amanda W Pain,Jeyaraj D Pandian,Puspa Raj Pant,Christina Papachristou,Eun-Kee Park,Jae-Hyun Park,Charles D. H. Parry,Mahboubeh Parsaeian,Angel J Paternina Caicedo,Angel J Paternina Caicedo,Scott B. Patten,George C Patton,Vinod K. Paul,Neil Pearce,João Mário Pedro,Ljiljana Pejin Stokic,David M. Pereira,Norberto Perico,Konrad Pesudovs,Max Petzold,Max Petzold,Michael R. Phillips,Michael R. Phillips,Frédéric B. Piel,Julian David Pillay,Dietrich Plass,James A Platts-Mills,Suzanne Polinder,C. Arden Pope,Svetlana Popova,Richie G Poulton,Farshad Pourmalek,Dorairaj Prabhakaran,Mostafa Qorbani,Justice Quame-Amaglo,D Alex Quistberg,D Alex Quistberg,Anwar Rafay,Kazem Rahimi,Vafa Rahimi-Movaghar,Mahfuzar Rahman,Mahfuzar Rahman,Mohammad Hifz Ur Rahman,Sajjad Ur Rahman,Rajesh Kumar Rai,Zhale Rajavi,Sasa Rajsic,Murugesan Raju,Ivo Rakovac,Saleem M Rana,Chhabi Lal Ranabhat,Thara Rangaswamy,Puja Rao,Sowmya R. Rao,Amany H Refaat,Amany H Refaat,Jürgen Rehm,Jürgen Rehm,Marissa B Reitsma,Giuseppe Remuzzi,Serge Resnikoff,Antonio Luiz Pinho Ribeiro,Stefano Ricci,Maria Jesus Rios Blancas,Bayard Roberts,Anna Roca,David Rojas-Rueda,Luca Ronfani,Gholamreza Roshandel,Gholamreza Roshandel,Dietrich Rothenbacher,Ambuj Roy,Nawal K Roy,George Mugambage Ruhago,Rajesh Sagar,Sukanta Saha,Ramesh Sahathevan,Muhammad Muhammad Saleh,Juan Sanabria,Juan Sanabria,Maria Dolores Sanchez-Niño,Lidia Sanchez-Riera,Itamar S. Santos,Rodrigo Sarmiento-Suarez,Benn Sartorius,Maheswar Satpathy,Miloje Savic,Monika Sawhney,Michael Schaub,Maria Inês Schmidt,Ione Jayce Ceola Schneider,Ben Schöttker,Aletta E. Schutte,Aletta E. Schutte,David C. Schwebel,Soraya Seedat,Sadaf G. Sepanlou,Edson Serván-Mori,Katya Anne Shackelford,Gavin Shaddick,Amira Shaheen,Saeid Shahraz,Masood Ali Shaikh,Marina Shakh-Nazarova,Rajesh Sharma,Jun She,Sara Sheikhbahaei,Jiabin Shen,Jiabin Shen,Ziyan Shen,Donald S. Shepard,Kevin N. Sheth,Balakrishna P Shetty,Peilin Shi,Kenji Shibuya,Min-Jeong Shin,Rahman Shiri,Ivy Shiue,Ivy Shiue,Mark G. Shrime,Inga Dora Sigfusdottir,Donald H. Silberberg,Diego Augusto Santos Silva,Dayane Gabriele Alves Silveira,Jonathan I. Silverberg,Edgar P. Simard,Abhishek Singh,Gitanjali M. Singh,Jasvinder A. Singh,Om Prakash Singh,Prashant Singh,Virendra Singh,Samir Soneji,Kjetil Søreide,Joan B. Soriano,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Vasiliki Stathopoulou,Dan J. Stein,Dan J. Stein,Murray B. Stein,Saverio Stranges,Konstantinos Stroumpoulis,Bruno F. Sunguya,Patrick J Sur,Soumya Swaminathan,Bryan L. Sykes,Cassandra Szoeke,Rafael Tabarés-Seisdedos,Karen M. Tabb,Ken Takahashi,Jukka S Takala,Roberto Tchio Talongwa,Nikhil Tandon,Mohammad Tavakkoli,Bineyam Taye,Hugh R. Taylor,Braden Te Ao,Bemnet Amare Tedla,Bemnet Amare Tedla,Worku Tefera,Margreet ten Have,Abdullah Sulieman Terkawi,Abdullah Sulieman Terkawi,Fisaha Haile Tesfay,Fisaha Haile Tesfay,Gizachew Assefa Tessema,Gizachew Assefa Tessema,Alan J Thomson,Andrew L. Thorne-Lyman,Amanda G. Thrift,George D Thurston,Taavi Tillmann,David L. Tirschwell,Marcello Tonelli,Roman Topor-Madry,Roman Topor-Madry,Fotis Topouzis,Jeffrey A. Towbin,Jefferson Traebert,Bach Xuan Tran,Bach Xuan Tran,Thomas Truelsen,Ulises Trujillo,Abera Kenay Tura,Emin Murat Tuzcu,Uche S. Uchendu,Kingsley N. Ukwaja,Eduardo A. Undurraga,Olalekan A. Uthman,Rita Van Dingenen,Aaron van Donkelaar,Aaron van Donkelaar,Tommi Vasankari,Ana Maria Nogales Vasconcelos,Narayanaswamy Venketasubramanian,Ramesh Vidavalur,Lakshmi Vijayakumar,Salvador Villalpando,Francesco Saverio Violante,Vasiliy Victorovich Vlassov,Joseph A Wagner,Gregory R Wagner,Mitchell T. Wallin,Linhong Wang,David A Watkins,David A Watkins,Scott Weichenthal,Elisabete Weiderpass,Robert G. Weintraub,Robert G. Weintraub,Andrea Werdecker,Ronny Westerman,Richard A. White,Tissa Wijeratne,Tissa Wijeratne,James D. Wilkinson,James D. Wilkinson,Hywel C Williams,Charles Shey Wiysonge,Charles Shey Wiysonge,Solomon Meseret Woldeyohannes,Charles D.A. Wolfe,Sungho Won,John Q. Wong,Anthony D. Woolf,Denis Xavier,Qingyang Xiao,Gelin Xu,Bereket Yakob,Ayalnesh Zemene Yalew,Lijing L Yan,Yuichiro Yano,Mehdi Yaseri,Pengpeng Ye,Henock Yebyo,Henock Yebyo,Paul S. F. Yip,Biruck Desalegn Yirsaw,Biruck Desalegn Yirsaw,Naohiro Yonemoto,Gerald Yonga,Mustafa Z. Younis,Shicheng Yu,Zoubida Zaidi,Maysaa El Sayed Zaki,Faiez Zannad,Diego E Zavala,Hajo Zeeb,Berihun M. Zeleke,Berihun M. Zeleke,Hao Zhang,Sanjay Zodpey,David Zonies,Liesl Zühlke,Theo Vos,Alan D. Lopez,Alan D. Lopez,Christopher J L Murray +844 more
TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
Journal ArticleDOI
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Jeffrey J. Iliff,Minghuan Wang,Minghuan Wang,Yonghong Liao,Benjamin A. Plogg,Weiguo Peng,Georg Andreas Gundersen,Helene Benveniste,G. Edward Vates,Rashid Deane,Steven A. Goldman,Erlend A. Nagelhus +11 more
TL;DR: An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.
Journal ArticleDOI
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
Journal ArticleDOI
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Pericytes regulate the blood–brain barrier
Annika Armulik,Guillem Genové,Maarja Mäe,Maya H. Nisancioglu,Elisabet Wallgard,Elisabet Wallgard,Colin Niaudet,Liqun He,Liqun He,Jenny Norlin,Per Lindblom,Karin Strittmatter,Karin Strittmatter,Bengt Johansson,Christer Betsholtz +14 more
TL;DR: A novel and critical role for pericytes is indicated in the integration of endothelial and astrocyte functions at the neurovascular unit, and in the regulation of the blood–brain barrier.